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皮肌炎（DM）是一種累及皮膚和橫紋肌的自身免疫性結締組織病，通常呈現亞急性或慢性發病。其病因尚不明確，可能與自身免疫、感染、腫瘤及遺傳因素相關。成人皮肌炎的年發病率為（5-10/100 萬，男女比例約1∶2，發病年齡呈現雙峰分布，即兒童期（5-15歲）和45-65歲的成年人高發。臨床上，皮肌炎主要表現為皮膚和肌肉受累癥狀，如特征性的Heliotrope征、Gottron丘疹，以及對稱性四肢近端肌群和頸部肌無力等，部分患者還可能伴發惡性腫瘤或出現間質性肺病等并發癥。?

近年來針對皮肌炎的新型藥物不斷涌現。生物制劑成為研發熱點之一，例如抗白細胞介素 - 6 受體拮抗劑等針對特定細胞因子或免疫通路的藥物，已顯示出一定治療潛力。以利妥昔單抗為例，在難治性青少年皮肌炎（JDM）治療中，對458例患者的臨床數據分析顯示，78.3%患者的皮膚和肌肉癥狀得到改善，且多數患者肌炎特異性自身抗體結果呈陽性改變，癥狀未反復。此外，小分子靶向藥物也在探索階段。在jak抑制劑中，托法替布是美國食品藥品監督管理局（FDA）首個批準用于治療自身免疫性疾病的該類藥物，多個案例報告證實其對嚴重皮膚疾病和難治性DM患者有效，可改善皮膚疹、關節疼痛、肌肉力量，還能減少皮質類固醇治療需求。2025年2月，上海交通大學醫學院附屬仁濟醫院風濕科葉霜教授團隊研究顯示，托法替布作為初始免疫抑制方案，對抗MDA5陽性皮肌炎合并間質性肺病患者的1年無肺移植生存獲益顯著高于鈣調磷酸酶抑制劑。

皮肌炎（DM）在研藥物靶點

皮肌炎（DM）藥物靶點相關產品推薦

● 靶點蛋白

CD7
CSB-MP004953HU

Measured by its binding ability in a functional ELISA. Immobilized CD7 at 5 μg/ml can bind SECTM1 (CSB-MP819898HU), the EC₅₀ is 1.236-1.773 ng/ml.

GLP1R
CSB-MP009514HUb1

Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC₅₀ is 54.54-94.23 ng/mL.

IL6
CSB-EP011664HU

The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 0.1518 - 0.3987 ng/mL.

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

Target	Product Name	Source	Tag Info	Code
C5	Recombinant Human Complement C5 (C5), partial	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP003995HU
C5	Recombinant Rat Complement C5 (C5)	E.coli	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-EP003995RA
C5	Recombinant Human Complement C5 (C5), partial	Mammalian cell	N-terminal 6xHis-Myc-tagged	CSB-MP003995HU
C5	Recombinant Pig Complement C5a anaphylatoxin (C5)	Yeast	N-terminal 6xHis-tagged	CSB-YP003995PI
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial	in vitro E.coli expression system	N-terminal 6xHis-tagged	CSB-CF004888HU
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial	in vitro E.coli expression system	C-terminal 6xHis-tagged	CSB-CF004888HUc7
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-MP004888HU
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active)	Mammalian cell	C-terminal Fc-tagged	CSB-AP005061HU
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial, Biotinylated	Mammalian cell	C-terminal hFc1-Avi-tagged	CSB-MP004888HU-B
CD6	Recombinant Human T-cell differentiation antigen CD6(CD6), partial	Yeast	C-terminal 6xHis-Myc-tagged	CSB-YP326953HU
CD6	Recombinant Human T-cell differentiation antigen CD6(CD6), partial	Yeast	N-terminal 6xHis-tagged	CSB-YP326953HUa0
CD7	Recombinant Human T-cell antigen CD7 (CD7), partial	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP004953HU
CD7	Recombinant Human T-cell antigen CD7 (CD7), partial	Yeast	N-terminal 6xHis-tagged	CSB-YP004953HU
CD7	Recombinant Human T-cell antigen CD7 (CD7), partial (Active)	Mammalian cell	C-terminal hFc1-Myc-tagged	CSB-MP004953HU
CD7	Recombinant Human T-cell antigen CD7 (CD7), partial	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-MP004953HUb1
CD7	Recombinant Human T-cell antigen CD7 (CD7), partial, Biotinylated	Mammalian cell	C-terminal mFc-Avi-tagged	CSB-MP004953HU-B
Cfb	Recombinant Mouse Complement factor B (Cfb)	E.coli	N-terminal 6xHis-tagged	CSB-EP005268MO
Cfb	Recombinant Mouse Complement factor B (Cfb)	Mammalian cell	C-terminal 10xHis-tagged	CSB-MP005268MO
Cfb	Recombinant Mouse Complement factor B (Cfb)	E.coli	C-terminal 6xHis-tagged	CSB-EP005268MOc7
CGAS	Recombinant Human Cyclic GMP-AMP synthase (CGAS), partial	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP822726HU

● 抗體

C5 Recombinant Monoclonal Antibody
CSB-RA003995MA1HU

Tested Applications:
ELISA, FC

CD19 Recombinant Monoclonal Antibody
CSB-RA780821A0HU

Tested Applications:
ELISA, WB, IHC, IP

Phospho-JAK2 (Y1007 + Y1008) Recombinant Monoclonal Antibody
CSB-RA011931A100phHU

Tested Applications:
ELISA, WB, IHC, IP

PDCD1 Recombinant Monoclonal Antibody
CSB-RA240597A0HU

Tested Applications:
ELISA, WB, IHC

- 重組抗體

Target	Product Name	Species Reactivity	Tested Applications	Code
C5	C5 Recombinant Monoclonal Antibody	Human	ELISA, FC	CSB-RA003995MA1HU
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA004888A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IP	CSB-RA780821A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB	CSB-RA004888MA1HU
GLP1R	GLP1R Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA009514MA1HU
IFNAR1	IFNAR1 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA011046A0HU
IL23A	IL23A Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA251959A0HU
JAK1	JAK1 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA227790A0HU
JAK2	Phospho-JAK2 (Y1007 + Y1008) Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IP	CSB-RA011931A100phHU
JAK2	JAK2 Recombinant Monoclonal Antibody	Human	ELISA, IF	CSB-RA267127A0HU
JAK3	JAK3 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA206737A0HU
LTA	LTA Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA013218A0HU
MS4A1	CD20 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A0HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A1HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human, Dog, Macaca fascicularis	ELISA	CSB-RA015007MA3HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF	CSB-RA015007MA4HU
NR3C1	NR3C1 Recombinant Monoclonal Antibody	Human	ELISA, WB, FC	CSB-RA958910A0HU
PDCD1	PDCD1 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA240597A0HU
S1PR1	S1PR1 Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA923827A0HU
TLR7	TLR7 Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA556665A0HU

- 單克隆抗體

Target	Product Name	Species Reactivity	Tested Applications	Code
CD19	CD19 Monoclonal Antibody	Human	ELISA, WB, IHC, IF, FC	CSB-MA004888A0m
CD19	CD19 Monoclonal Antibody	Human	ELISA, WB, IHC, FC	CSB-MA004888A1m
CD19	CD19 Monoclonal Antibody,APC Conjugated	Human	ELISA, IF, FC	CSB-MA195220
CD19	CD19 Monoclonal Antibody,Biotin Conjugated	Human	ELISA, IF, FC	CSB-MA899608
CD19	CD19 Monoclonal Antibody,FITC Conjugated	Human	ELISA, IF, FC	CSB-MA047662
CD19	CD19 Monoclonal Antibody,PE Conjugated	Human	ELISA, IF, FC	CSB-MA036486
CD19	CD19 Monoclonal Antibody,PE-Cy5 Conjugated	Human	ELISA, IF, FC	CSB-MA281869
CD19	CD19 Monoclonal Antibody,Purified	Human	ELISA, FC	CSB-MA798261
JAK1	JAK1 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA919964
JAK2	JAK2 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA181103
JAK2	JAK2 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA780030
MS4A1	MS4A1 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA000204
MS4A1	MS4A1 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA996413
TNF	TNF Monoclonal Antibody	Bovine	ELISA	CSB-MA084771A0m
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080271
TNF	TNF Monoclonal Antibody	Human,Mouse,Rat	ELISA, WB, IHC	CSB-MA080272
TNFRSF17	TNFRSF17 Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-MA023974A0m
TNFRSF17	TNFRSF17 Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-MA023974A1m

- 多克隆抗體

Target	Product Name	Species Reactivity	Tested Applications	Code
C5	C5 Antibody	Human	ELISA, IHC	CSB-PA003995LA01HU
C5	C5 Antibody	Pig	ELISA, IHC	CSB-PA003995YA01PI
CD19	CD19 Antibody	Human, Mouse, Monkey	ELISA, WB	CSB-PA001431
CD19	Phospho-CD19 (Y531) Antibody	Human, Mouse, Monkey	ELISA, WB	CSB-PA070286
CD19	CD19 Antibody	Human	ELISA, WB	CSB-PA006159
CD19	CD19 (Ab-531) Antibody	Human, Mouse	ELISA, WB	CSB-PA253616
CD19	Phospho-CD19 (Tyr531) Antibody	Human, Mouse	ELISA, WB	CSB-PA058389
CD6	CD6 Antibody	Human	ELISA, WB, IHC	CSB-PA326953ESR1HU
CD6	CD6 Antibody	Human	ELISA, IHC	CSB-PA326953ESR2HU
CD6	CD6 Antibody	Human	ELISA, WB	CSB-PA006156
CD6	CD6 Antibody	Human	ELISA, WB	CSB-PA070265
CD6	CD6 Antibody	Human	ELISA, WB	CSB-PA134350
CD7	CD7 Antibody	Human	ELISA, IHC	CSB-PA004953YA01HU
CD7	CD7 Antibody	Human	ELISA, IHC	CSB-PA004953ESR1HU
CD7	CD7 Antibody	Human	ELISA, WB	CSB-PA005197
CFB	CFB Antibody	Human	ELISA, WB, IHC	CSB-PA11049A0Rb
Cfb	Cfb Antibody	Mouse, Human	ELISA, WB	CSB-PA005268LA01MO
CFB	Cleaved-CFB (K260) Antibody	Human, Mouse	ELISA, WB	CSB-PA040288
CFB	CFB Antibody	Human, Mouse, Rat	ELISA, WB	CSB-PA005268GA01HU
CNR2	CNR2 Antibody	Human	ELISA, IHC, IF	CSB-PA005679LA01HU

● ELISA試劑盒

Rat TNF-α ELISA kit
CSB-E11987r

Mouse Interferon β,IFN-β/IFNB ELISA Kit
CSB-E04945m

Mouse Tumor necrosis factor β,TNF-β ELISA KIT
CSB-E04744m

Bovine Interleukin 12,IL-12 ELISA Kit
CSB-E14010B

Target	Product Name	Sample Types	Detection Range	Code
TNF	Rat TNF-α ELISA kit	serum, plasma, cell culture supernates, tissue homogenates	6.25 pg/mL-400 pg/mL	CSB-E11987r
TNF	Mouse Tumor necrosis factor α,TNF-α ELISA KIT	serum, plasma, cell culture supernates, tissue homogenates	15.6 pg/ml-1000 pg/ml	CSB-E04741m
TNF	Human Tumor necrosis factor α,TNF-α ELISA KIT	serum, plasma, cell culture supernates, tissue homogenates, cell lysates	7.8 pg/mL-500 pg/mL	CSB-E04740h
TNF	Bovine TNF-αELISA kit	serum, plasma, tissue homogenates	0.1 ng/mL-20 ng/mL	CSB-E12020B
TNF	Rabbit Tumor necrosis factor α,TNFα ELISA Kit	serum, plasma, tissue homogenates, cell lysates	78 pg/mL-5000 pg/mL	CSB-E06998Rb
IFNB1	Mouse Interferon β,IFN-β/IFNB ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates, cell lysates	15.6 pg/mL-1000 pg/mL	CSB-E04945m
IFNB1	Human Interferon β,IFN-β/IFNB ELISA Kit	serum, urine, cell culture supernates, tissue homogenates, cerebrospinal fluid (CSF)	31.25 pg/mL-2000 pg/mL	CSB-E09889h
TNF	Pig Tumor necrosis factor (TNF/TNFA/TNFSF2) ELISA kit	serum, plasma, cell culture supernates, tissue homogenates	0.047 ng/mL-3 ng/mL	CSB-E16980p
TNF	Guinea pig Tumor necrosis factor α,TNF-α ELISA Kit	serum, plasma, tissue homogenates	3.12 pg/mL-200 pg/mL	CSB-E06772Gu
TNF	Sheep Tumor Necrosis Factor α,TNF-α ELISA Kit	serum, plasma, tissue homogenates	3.125 pg/mL-50 pg/mL	CSB-E13853Sh
TNF	Goat Tumor necrosis factor α,TNF-α ELISA KIT	serum, plasma, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-E09811g
LTA	Mouse Tumor necrosis factor β,TNF-β ELISA KIT	serum, plasma, tissue homogenates	18.75 pg/mL-1200 pg/mL	CSB-E04744m
IL12A	Bovine Interleukin 12,IL-12 ELISA Kit	serum, plasma, tissue homogenates	6.25 pg/mL-400 pg/mL	CSB-E14010B
PDCD1	Human Programmed Death 1(PD-1)ELISA KIT	serum, plasma, tissue homogenates, cell lysates	15.6 pg/mL-1000 pg/mL	CSB-E13643h
NR3C1	Rat glucocorticoid receptor,GR ELISA Kit	serum, plasma, tissue homogenates, cell lysates	15.6 pg/mL-1000 pg/mL	CSB-E08747r
LTA	Human Tumor necrosis factor β,TNF-β ELISA KIT	serum, plasma, cell culture supernates	15.6 pg/mL-1000 pg/mL	CSB-E04743h
IFNB1	Rat Interferon β,IFN-β/IFNB ELISA Kit	serum, plasma, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-E04845r
IFNB1	Bovine Interferon β,IFN-β/IFNB ELISA Kit		Request Information	CSB-E13699B
TNF	Horse Tumor necrosis factor α,TNF-α ELISA Kit	serum, plasma, tissue homogenates	15.6 pg/mL-1000 pg/mL	CSB-E14031Hs
CFB	Human factor B,BF ELISA Kit	serum, plasma	1.56 ng/mL-100 ng/mL	CSB-E09447h