LTA
LTA基因編碼TNF-β蛋白（腫瘤壞死因子β），也稱為淋巴毒素α（Lymphotoxin Alpha，LT-α），屬于TNSF超家族一員。根據(jù)TNF來源的不同，人們將單核/巨噬細(xì)胞所產(chǎn)生的TNF稱腫瘤壞死因子α；把T細(xì)胞產(chǎn)生的TNF稱為腫瘤壞死因子（TNF-β）。TNF-β有膜結(jié)合和可溶性兩種形式，分泌到細(xì)胞外的可溶性形式稱為LT-α。LT-α主要由活化的CD4+CD8+T細(xì)胞、NK細(xì)胞、B淋巴母細(xì)胞樣細(xì)胞、骨髓瘤細(xì)胞等產(chǎn)生。LT-α在細(xì)菌的代謝和致病過程中發(fā)揮重要的作用。研究證實在感染結(jié)核分支桿菌后，遺傳性LT-a缺陷的小鼠比LT-a正常小鼠屯集更多的細(xì)菌負(fù)荷量。TNF-β除了介導(dǎo)許多炎癥、免疫刺激和抗病毒應(yīng)答。在發(fā)育階段，TNF-β還參與二級淋巴器官的形成，并在凋亡中發(fā)揮作用。在TNF-β敲除小鼠中，所有派伊爾氏淋巴集結(jié)和淋巴結(jié)都無法發(fā)育，這表明了TNF-β在免疫系統(tǒng)發(fā)育中的重要性。
Recombinant Human LTA 活性蛋白實驗驗證數(shù)據(jù)
by SDS-PAGE
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized LTA at 5 μg/ml can bind human TNFRSF1B (CSB-MP023978HU2), the EC50 is 1.632-2.699 ng/ml.
Measured by its binding ability in a functional ELISA. Immobilized LTA at 5 μg/ml can bind human TNFR1(CSB-MP023977HU1), the EC50 of human LTA protein is 4.409-6.797 ng/ml.
LTA Antibodies
LTA for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA013218KA01HU | LTA Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA004313 | LTA Antibody | Human,Mouse,Rat,Monkey | WB, ELISA |
| CSB-PA863040 | LTA Antibody | Human | ELISA,IHC |
| CSB-RA013218A0HU | LTA Recombinant Monoclonal Antibody | Human | ELISA |
LTA Proteins
LTA Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013218RB CSB-EP013218RB CSB-BP013218RB CSB-MP013218RB CSB-EP013218RB-B |
Recombinant Rabbit Lymphotoxin-alpha (LTA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LTA Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013218PI CSB-EP013218PI CSB-BP013218PI CSB-MP013218PI CSB-EP013218PI-B |
Recombinant Pig Lymphotoxin-alpha (LTA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LTA Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013218HU CSB-EP013218HU CSB-BP013218HU CSB-EP013218HU-B |
Recombinant Human Lymphotoxin-alpha (LTA) | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-AP002171HU | Recombinant Human Lymphotoxin-alpha protein (LTA) | E.Coli |
| CSB-AP004941HU | Recombinant Human Lymphotoxin-alpha (LTA) (Active) | E.coli |
| CSB-MP013218HU | Recombinant Human Lymphotoxin-alpha (LTA) (Active) | Mammalian cell |
| CSB-MP013218HU-B | Recombinant Human Lymphotoxin-alpha (LTA), partial,Biotinylated | Mammalian cell |
LTA Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013218MO CSB-BP013218MO CSB-MP013218MO CSB-EP013218MO-B |
Recombinant Mouse Lymphotoxin-alpha (Lta) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP013218MO | Recombinant Mouse Lymphotoxin-alpha (Lta) | E.coli |
| CSB-EP013218MOa0 | Recombinant Mouse Lymphotoxin-alpha (Lta) | E.coli |
LTA Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP013218EQV CSB-EP013218EQV CSB-BP013218EQV CSB-MP013218EQV CSB-EP013218EQV-B |
Recombinant Pan troglodytes Lymphotoxin-alpha (LTA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LTA Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP713142MOW CSB-EP713142MOW CSB-BP713142MOW CSB-MP713142MOW CSB-EP713142MOW-B |
Recombinant Macaca mulatta Lymphotoxin-alpha (LTA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LTA Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP730213DO CSB-EP730213DO CSB-BP730213DO CSB-MP730213DO CSB-EP730213DO-B |
Recombinant Dog Lymphotoxin-alpha (LTA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LTA Proteins for Marmota monax (Woodchuck)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP862417MQG CSB-EP862417MQG CSB-BP862417MQG CSB-MP862417MQG CSB-EP862417MQG-B |
Recombinant Marmota monax Lymphotoxin-alpha (LTA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LTA Proteins for Macropus eugenii (Tammar wallaby)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP894074MPE CSB-EP894074MPE CSB-BP894074MPE CSB-MP894074MPE CSB-EP894074MPE-B |
Recombinant Macropus eugenii Lymphotoxin-alpha (LTA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LTA ELISA Kit
LTA ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04743h | Human Tumor necrosis factor β,TNF-β ELISA KIT | serum, plasma, cell culture supernates | 3.9 pg/mL |
LTA ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04744m | Mouse Tumor necrosis factor β,TNF-β ELISA KIT | serum, plasma, tissue homogenates | 4.7 pg/mL |
LTA ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E07379r | Rat Tumor necrosis factor β,TNF-β ELISA KIT | serum, plasma, tissue homogenates | 1.95 pg/mL |
