潰瘍性結腸炎是一種慢性非特異性腸道炎癥性疾病，主要累及結腸和直腸，屬于炎癥性腸病（IBD）的亞型。其病因與遺傳易感性、免疫系統異常激活、腸道菌群失衡及環(huán)境因素（如吸煙、飲食）密切相關。患者表現為持續(xù)或反復發(fā)作的腹瀉、黏液膿血便、腹痛及里急后重感，嚴重時可并發(fā)中毒性巨結腸或腸穿孔。
近年來，潰瘍性結腸炎（UC）藥物研發(fā)正從廣譜抗炎轉向靶向調控，生物制劑（如IL-23、TL1A抑制劑）和精準小分子（如S1PR1偏向性激動劑）成為前沿方向。同時，中藥多靶點調控和新型技術（納米藥物、表觀遺傳干預）為突破現有治療瓶頸提供了新思路：
► 生物制劑類
- IL-23/IL-12通路：信達生物的匹康奇拜單抗（IL-23p19單抗）在II期臨床中療效和安全性優(yōu)異，是國內首個進入UC適應癥研發(fā)的IL-23靶點藥物；默沙東的MK-7240（TL1A抑制劑）在II期臨床中顯著改善中重度UC患者內鏡評分，12周臨床緩解率達26.5%，已進入III期臨床。
- 整合素靶點：Vedolizumab通過阻斷淋巴細胞遷移至腸道黏膜，在頭對頭對比中優(yōu)于阿達木單抗；同靶點的Etrolizumab因療效不穩(wěn)定未達預期。
- 趨化因子及炎癥因子：孟德爾隨機化研究表明CXCL5降低IBD風險，CXCL9增加風險，提示其作為治療靶點的潛力 [1]；基因預測的CD40水平降低與IBD風險降低相關，可能通過調節(jié)免疫細胞相互作用發(fā)揮作用。
► 小分子藥物
- S1P受體：SAR247799通過偏向性激活S1PR1的G蛋白信號通路，維持內皮屏障完整性，副作用低于非選擇性S1P調節(jié)劑；輝瑞的Etrasimod和已獲批的Ozanimod在中重度UC后線治療中展現合理療效。
- JAK-STAT通路：JAK抑制劑如托法替布通過阻斷炎癥信號通路改善UC癥狀，但存在心血管和感染風險，限制了其臨床應用。
- 嘌呤能信號通路：中國藥科大學團隊發(fā)現抑制P2Y14R可通過cAMP/PKA/CREB軸減少腸上皮細胞壞死性凋亡，緩解UC病理損傷，成為新型小分子藥物開發(fā)靶點。
► 中藥多靶點調控
- 黃芩-黃連藥對通過AKT1、IL-6、TNF等多靶點調控細胞因子信號、氧化應激和凋亡通路，核心靶點包括CASP3、PTGS2等 [2]。
- 青蒿素通過靶向GALNT2、BMP7和TGFBR2等蛋白，調節(jié)免疫和炎癥反應，結合計算機輔助設計優(yōu)化藥物結構 [3]。
► 新型靶點及技術
- 表觀遺傳調控：浙江大學團隊發(fā)現Sirpa基因位點的增強子RNA通過調控巨噬細胞SIRPα表達，成為UC治療的新靶點，反義寡核苷酸已在小鼠模型中驗證療效。
- 蛋白互作靶點：PDIA1在UC患者腸上皮中高表達，抑制PDIA1可改善腸屏障功能，已進入藥物篩選階段；巨噬細胞特異性敲除NOC4L可緩解UC癥狀，作為診斷標志物和治療靶點具有潛力。
- 納米藥物遞送系統：通過納米顆粒遞送藥物調控巨噬細胞極化，減少IL-1β、TNF-α等炎性因子釋放。
華美生物長期致力于為科研工作者提供高質量的蛋白、抗體、ELISA試劑盒等工具類科研試劑產品，特整理了一系列與潰瘍性結腸炎研究相關的熱門靶點及相關試劑產品列舉如下，供您選擇：
潰瘍性結腸炎在研藥物靶點
潰瘍性結腸炎藥物靶點相關產品推薦
● 靶點蛋白
CSB-MP004936HU1
Measured by its binding ability in a functional ELISA. Immobilized CD40 at 2 μg/ml can bind CD40L (CSB-MP004937HU3), the EC50 is 3.112-3.858 ng/ml.
CSB-MP006163HU1
Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody(CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.
CSB-MP011649HU3
Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU)，the EC50 is 2.463-3.353 ng/mL.
CSB-MP011661HU2-B
Measured by its binding ability in a functional ELISA. Immobilized Human IL4(CSB-MP011659HU) at 2μg/mL can bind biotinylated Human IL4R，the EC50 is 12.68-14.23 ng/mL
CSB-MP015007HU
Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL.
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP023992HU(F2)
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Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF15 at 2 μg/ml can bind Anti-TNFSF15 recombinant antibody(CSB-RA023992MA1HU). The EC50 is 0.8389-0.9731 ng/mL
CSB-MP023996HU1
Measured by its binding ability in a functional ELISA. Immobilized CD30(CSB-MP023983HU1h6) at 5 μg/ml can bind human CD30L, the EC50 is 9.531-12.49 ng/ml.
| Target | Product Name | Source | Tag Info | Code |
|---|---|---|---|---|
| CCL11 | Recombinant Human Eotaxin (CCL11) | E.coli | N-terminal GST-tagged | CSB-EP004775HU |
| CCL20 | Recombinant Human C-C motif chemokine 20 (CCL20), partial | E.coli | N-terminal GST-tagged | CSB-EP004784HU1 |
| CCL20 | Recombinant Macaca mulatta Chemokine CCL20/MIP-3ALPHA (CCL20) | E.coli | N-terminal 10xHis-GST-tagged | CSB-EP004784MOW |
| CCL20 | Recombinant Macaca mulatta Chemokine CCL20/MIP-3ALPHA (CCL20) | E.coli | N-terminal GST-tagged | CSB-EP004784MOWe0 |
| CCL20 | Recombinant Bovine C-C motif chemokine 20 (CCL20) | E.coli | N-terminal 6xHis-SUMO-tagged | CSB-EP840478BO |
| CCL20 | Recombinant Bovine C-C motif chemokine 20 (CCL20) | Yeast | N-terminal 6xHis-tagged | CSB-YP840478BO |
| CCL20 | Recombinant Human C-C motif chemokine 20 (CCL20), partial | E.coli | N-terminal 6xHis-GST-tagged | CSB-EP004784HU1c0 |
| CCR5 | Recombinant Human C-C chemokine receptor type 5 (CCR5) | in vitro E.coli expression system | N-terminal 10xHis-tagged | CSB-CF004844HU |
| Ccr5 | Recombinant Mouse C-C chemokine receptor type 5 (Ccr5), partial | Yeast | N-terminal 6xHis-tagged | CSB-YP004844MO |
| CD40 | Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) | Mammalian cell | C-terminal Fc-tagged | CSB-AP005181HU |
| CD40 | Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) | Mammalian cell | C-terminal hFc-tagged | CSB-MP004936HU1 |
| CD40 | Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial | E.coli | C-terminal 6xHis-tagged | CSB-EP851448PI |
| CD40 | Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial | Yeast | C-terminal hFc-tagged | CSB-YP851448PI |
| CD40 | Recombinant Pig Tumor necrosis factor receptor superfamily member 5 (CD40), partial | Yeast | C-terminal 6xHis-tagged | CSB-YP851448PIc7 |
| CD40 | Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial | Baculovirus | C-terminal hFc-Avi-tagged | CSB-BP004936HU1 |
| CTLA4 | Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial | E.coli | N-terminal 6xHis-tagged | CSB-EP006163HU1 |
| Ctla4 | Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial | E.coli | N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged | CSB-EP006163MO1 |
| CTLA4 | Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) | Yeast | C-terminal 6xHis-tagged | CSB-AP005121GU |
| Ctla4 | Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active) | Mammalian cell | C-terminal 6xHis-tagged | CSB-AP005301MO |
| CTLA4 | Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) | Mammalian cell | C-terminal hFc-tagged | CSB-MP006163HU1 |
● 抗體
CSB-RA004936MA1HU
Tested Applications:
ELISA, IF, FC
CSB-RA006163MA1HU
Tested Applications:
ELISA, WB, IF, FC
CSB-RA014679MA1HU
Tested Applications:
ELISA, IHC
CSB-RA240597A0HU
Tested Applications:
ELISA, WB, IHC
- 重組抗體
| Target | Product Name | Species Reactivity | Tested Applications | Code |
|---|---|---|---|---|
| CD40 | CD40 Recombinant Monoclonal Antibody | Human | ELISA, IF, FC | CSB-RA004936MA1HU |
| CTLA4 | CTLA4 Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA213310A0HU |
| CTLA4 | CTLA4 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB, IF, FC | CSB-RA006163MA1HU |
| CXCL10 | CXCL10 Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA903061A0HU |
| IL12B | IL12B Recombinant Monoclonal Antibody | Human | ELISA, FC | CSB-RA895985A0HU |
| IL23A | IL23A Recombinant Monoclonal Antibody | Human | ELISA, WB | CSB-RA251959A0HU |
| IL2RA | IL2RA Recombinant Monoclonal Antibody | Human | ELISA, IF | CSB-RA011649MA1HU |
| MADCAM1 | MADCAM1 Recombinant Monoclonal Antibody | Human | ELISA, FC | CSB-RA215817A0HU |
| MMP9 | MMP9 Recombinant Monoclonal Antibody | Human | ELISA, IHC, FC | CSB-RA014679A0HU |
| MS4A1 | CD20 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA015007A0HU |
| MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA015007A1HU |
| MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human, Dog, Macaca fascicularis | ELISA | CSB-RA015007MA3HU |
| MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF | CSB-RA015007MA4HU |
| PDCD1 | PDCD1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC | CSB-RA240597A0HU |
| SELPLG | SELPLG Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA567010A0HU |
- 單克隆抗體
| Target | Product Name | Species Reactivity | Tested Applications | Code |
|---|---|---|---|---|
| CTLA4 | CTLA4 Monoclonal Antibody | Human | ELISA, WB, IHC | CSB-MA006163A0m |
| IL2RA | IL2RA Monoclonal Antibody | Human | ELISA, IHC | CSB-MA000266 |
| LAG3 | LAG3 Monoclonal Antibody | Human | ELISA, WB, IHC, FC | CSB-MA012719A0m |
| MS4A1 | MS4A1 Monoclonal Antibody | Human,Mouse,Rat | ELISA, IHC | CSB-MA000204 |
| MS4A1 | MS4A1 Monoclonal Antibody | Human | ELISA, IHC | CSB-MA996413 |
| TNF | TNF Monoclonal Antibody | Bovine | ELISA | CSB-MA084771A0m |
| TNF | TNF Monoclonal Antibody | Human,Mouse,Rat | ELISA, WB, IHC | CSB-MA080271 |
| TNF | TNF Monoclonal Antibody | Human,Mouse,Rat | ELISA, WB, IHC | CSB-MA080272 |
- 多克隆抗體
| Target | Product Name | Species Reactivity | Tested Applications | Code |
|---|---|---|---|---|
| CCL11 | CCL11 Antibody | Human | ELISA, WB, IHC | CSB-PA004775ESR2HU |
| CCL11 | CCL11 Antibody | Human, Mouse, Rat | ELISA, WB | CSB-PA005780 |
| CCL11 | CCL11 Antibody | Human, Mouse, Rat | ELISA, WB | CSB-PA004775GA01HU |
| CCL20 | CCL20 Antibody | Human, Mouse | ELISA, IHC | CSB-PA389153 |
| Ccr5 | Ccr5 Antibody | Mouse | ELISA | CSB-PA004844LA01MO |
| CCR5 | CCR5 Antibody | Human, Mouse | ELISA, WB, IF | CSB-PA004844LA01HU |
| CCR5 | Phospho-CCR5 (S349) Antibody | Human | ELISA, WB | CSB-PA000640 |
| CCR5 | CCR5 Antibody | Human | ELISA, WB | CSB-PA006994 |
| CCR5 | Phospho-CCR5 (S336) Antibody | Human, Mouse, Rat | ELISA, WB | CSB-PA006995 |
| CCR5 | CCR5 Antibody | Human, Mouse, Rat | ELISA, IHC | CSB-PA006993 |
| CCR5 | CCR5 Antibody | Human | ELISA, WB, IHC | CSB-PA792075 |
| CCR5 | CCR5 Antibody | Human, Mouse, Rat | ELISA, WB | CSB-PA004844GA01HU |
| CCR5 | CCR5 Antibody | Human, Mouse | ELISA, IHC | CSB-PA548882 |
| CCR5 | CCR5 Antibody | Human, Mouse | ELISA, IHC | CSB-PA265884 |
| CCR5 | CCR5 Antibody | Human | ELISA, WB | CSB-PA572290 |
| CCR5 | Phospho-CCR5 (Ser349) Antibody | Human | ELISA, WB | CSB-PA942331 |
| CD3D | CD3D Antibody | Human | ELISA, IHC | CSB-PA004930ESR1HU |
| CD3D | CD3D Antibody | Human | ELISA, WB | CSB-PA001452 |
| CD3D | CD3D Antibody | Human | ELISA, WB | CSB-PA005826 |
| CD3D | CD3D Antibody | Human, Mouse, Rat | ELISA, WB, IF | CSB-PA004930GA01HU |
● ELISA試劑盒
Bovine Interleukin 12,IL-12 ELISA Kit
CSB-E14010B
Goat interleukin 12,IL-12/P40 ELISA KIT
CSB-E12103G
Mouse Tumor necrosis factor α,TNF-α ELISA Kit
CSB-E04741m-IS
Human Interleukin 12,IL-12/P40 ELISA KIT
CSB-E04598h
| Target | Product Name | Sample Types | Detection Range | Code |
|---|---|---|---|---|
| CCL11 | Human eosinophil chemotactic factor,ECF ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 31.25 pg/mL-2000 pg/mL | CSB-E04533h |
| CCL11 | Rat Eotaxin 1 (Eotaxin 1/CCL11/ECF)ELISA Kit | serum, plasma, tissue homogenates | 15.6 pg/ml -1000 pg/ml | CSB-E07319r |
| CCL20 | Human Macrophage Inflammatory Protein-3α,MIP-3α ELISA kit | serum, plasma, cell culture supernates | 15.6 pg/mL-1000 pg/mL | CSB-E04667h |
| CCL20 | Mouse Macrophage Inflammatory Protein 3α,MIP-3α ELISA kit | serum, plasma, tissue homogenates | 39 pg/ml - 2500 pg/ml | CSB-E04668m |
| CCL20 | Rat macrophage inflammatory protein 3α,MIP-3α ELISA Kit | serum, plasma, tissue homogenates | 0.156 ng/ml - 10 ng/ml | CSB-E04669r |
| CD40 | Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit | Request Information | CSB-EL004936MO | |
| CD6 | Mouse cluster of differentiation 6(CD6) ELISA Kit | Request Information | CSB-EL004949MO | |
| CTLA4 | Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit | serum, plasma, tissue homogenates | 125 pg/mL-8000 pg/mL | CSB-E09171h |
| CTLA4 | Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit | serum, plasma, tissue homogenates | 0.312 ng/mL-20 ng/mL | CSB-E13637m |
| CXCL10 | Human interferon-inducible protein 10,IP-10 ELISA Kit | serum, plasma, tissue homogenates | 31.25 pg/mL-2000 pg/mL | CSB-E08181h |
| CXCL10 | Rat interferon-inducible protein 10,IP-10 ELISA Kit | serum, plasma, tissue homogenates | 781.25 pg/mL-50000 pg/mL | CSB-E08182r |
| CXCL10 | Mouse interferon-inducible protein 10,IP-10 ELISA Kit | serum, plasma, tissue homogenates | 0.312 ng/ml - 20 ng/ml | CSB-E08183m |
| CXCL10 | Monkey C-X-C motif chemokine 10(CXCL10) ELISA kit | serum, plasma, tissue homogenates | 62.5 pg/mL-4000 pg/mL | CSB-EL006240RH |
| IL12A | Bovine Interleukin 12,IL-12 ELISA Kit | serum, plasma, tissue homogenates | 6.25 pg/mL-400 pg/mL | CSB-E14010B |
| IL12B | Human Interleukin 12,IL-12/P40 ELISA KIT | serum, plasma, tissue homogenates | 0.156 ng/ml-10 ng/ml | CSB-E04598h |
| IL12B | Mouse interleukin 12,IL-12/P40 ELISA KIT | serum, plasma, tissue homogenates | 15.6 pg/mL-1000 pg/mL | CSB-E07360m |
| IL12B | Pig Interleukin 12,IL-12/P40 ELISA KIT | serum, plasma, cell culture supernates | 15.6 pg/mL-1000 pg/mL | CSB-E11341p |
| IL12B | Goat interleukin 12,IL-12/P40 ELISA KIT | serum, plasma, tissue homogenates, cell lysates | 9.38 pg/mL-600 pg/mL | CSB-E12103G |
| IL13 | Human Interleukin 13,IL-13 ELISA KIT | serum, plasma, tissue homogenates | 0.39 ng/ml-25 ng/ml. | CSB-E04601h |
| IL13 | Mouse Interleukin 13,IL-13 ELISA Kit | serum, plasma, tissue homogenates | 78 pg/ml - 5000 pg/ml | CSB-E04602m |
藥物研發(fā)解決方案
特色服務項目
參考文獻：
[1] Identifying Novel Inflammatory Protein Biomarkers and Drug Targets of Inflammatory Bowel Disease by Integrating Mendelian Randomization, Bioinformatics, and Druggability Analysis. Int Arch Allergy Immunol, 2025.
[2] Molecular Targets and Mechanisms of Scutellariae radix - Coptidis rhizoma Drug Pair for the Treatment of Ulcerative Colitis Based on Network Pharmacology and Molecular Docking. Evid Based Complement Alternat Med, 2021.
[3] A Pharmacoinformatics Analysis of Artemisinin Targets and de novo Design of Hits for Treating Ulcerative Colitis. Front Pharmacol, 2022.
