IL23A Recombinant Monoclonal Antibody

中文名稱(chēng)：

IL23A重組抗體
貨號(hào)：

CSB-RA251959A0HU
規(guī)格：

￥1320
圖片：
Western Blot
Positive WB detected in: THP-1 whole cell lysate
All lanes: IL23 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 21 kDa
Observed band size: 21 kDa
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品描述：

IL23A Recombinant Monoclonal Antibody（Code: CSB-RA251959A0HU）是一款針對(duì)IL23A靶點(diǎn)的高特異性重組單克隆抗體，適用于檢測(cè)IL-23細(xì)胞因子的p19亞基。IL23A是IL-23異源二聚體的關(guān)鍵功能組分，通過(guò)與IL12B結(jié)合形成具有生物活性的IL-23，在Th17細(xì)胞分化、炎癥性免疫應(yīng)答及自身免疫性疾病發(fā)生中發(fā)揮核心調(diào)控作用。該抗體經(jīng)嚴(yán)格的驗(yàn)證體系測(cè)試，在ELISA和Western Blot（WB）實(shí)驗(yàn)平臺(tái)中展現(xiàn)出優(yōu)異性能，其中WB推薦的稀釋范圍為1:500至1:5000，可清晰識(shí)別內(nèi)源性IL23A蛋白條帶，且批間一致性穩(wěn)定。其高靈敏度和低交叉反應(yīng)性使其成為研究IL-23/IL-23R信號(hào)通路、炎癥相關(guān)疾病模型（如銀屑病、炎癥性腸病）及免疫調(diào)節(jié)機(jī)制的重要工具，適用于體外細(xì)胞實(shí)驗(yàn)、組織樣本分析等科研場(chǎng)景。通過(guò)優(yōu)化生產(chǎn)工藝，本產(chǎn)品在復(fù)雜樣本中仍保持穩(wěn)定的抗原結(jié)合能力，為探索IL-23A在先天性與適應(yīng)性免疫中的功能提供了可靠的研究支持。
Uniprot No.：

Q9NPF7
基因名：

IL23A
別名：

Interleukin-23 subunit alpha (IL-23 subunit alpha) (IL-23-A) (Interleukin-23 subunit p19) (IL-23p19), IL23A, SGRF
反應(yīng)種屬：

Human
免疫原：

A synthesized peptide derived from human IL23
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
克隆類(lèi)型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號(hào)：

1F6
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
基因功能參考文獻(xiàn)：
1. IL23 and IL17 have roles in the pathogenesis of Tunisian pemphigus foliaceus PMID: 30116153
2. Effect of polymorphisms in IL-12B p40, IL-17A and IL-23 A/G genes on the response of psoriatic patients to narrowband UVB. PMID: 29763989
3. Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. PMID: 29650963
4. IL-23 binding to its receptor promotes the migration and invasion of gastric cancer cells by inducing epithelial-to-mesenchymal transition through the STAT3 signaling pathway. PMID: 29574157
5. TNF-alpha plays an important role for the autocrine stimulation of IL-23 production by 6-sulfo LacNAc(+) dendritic cells. PMID: 27315572
6. The expression of IL-17 and IL-12 in patients with lupus miliaris disseminatus faciei is reported in patients and healthy controls. PMID: 27515793
7. SIGIRR is both a negative regulator of TLR4 and a positive regulator of TLR7/8. PMID: 28869081
8. interleukin 23 (IL-23)/T-helper 17 (TH 17) immune axis has been identified as a major immune pathway in psoriasis disease pathogenesis PMID: 28653490
9. Serum IL-17 and IL-23 values positively correlated with serum total IgE levels. Serum levels of IL-10 were lower in children with atopy and dyslipidemia than patients with dyslipidemia. PMID: 28692864
10. IL-23/IL-17 axis and biochemical markers in the pathogenesis of Type 2 Diabetes PMID: 28757426
11. Higher levels of TGF-beta mRNA were observed in biopsies taken from healthy controls, and the IL-23 mRNA levels were significantly increased in the peri-implantitis group (P < 0.0001). No differences in IL-17 mRNA levels were observed between the two groups (P > 0.05). PMID: 27062688
12. clinical significance of IL-17 and IL-23 in the pathogenesis of different types of gastric neoplasms in humans, is reported. PMID: 27869179
13. this study shows neuroprotective effects of G-CSF administration in microglia-mediated reactive T cell activation in vitro in a mouse model PMID: 28646409
14. NOD2 up-regulates TLR2-mediated IL-23p19 expression via increasing c-Rel activation in Paneth cell-like cells PMID: 27563808
15. Serum IL-23 and IL-17 levels were elevated in patients with aneurysmal subarachnoid hemorrhage (aSAH) showing upregulation of IL-23/IL-17 inflammatory axis after aSAH. Serum IL-23 and IL-17 showed differential correlations with post hemorrhagic complications and no correlation with clinical outcome. PMID: 28609751
16. IL-23, alone and in combination with IL-18 and sRAGE, identified bacterial meningitis with excellent accuracy. Following validation, these markers could aid clinicians in diagnosis of bacterial meningitis and decision-making regarding prolongation of antibiotic therapy PMID: 29394248
17. Serum IL-17F predicted increased knee bone marrow lesion scores in females only among patients with knee osteoarthritis. PMID: 27836676
18. Our discoveries demonstrate that autocrine IL-23 contribute to ovarian cancer malignancy through promoting the self-renewal of CD133+ ovarian cancer stem-like cells, and this suggests that IL-23 and its signaling pathway might serve as therapeutic targets for the treatment of ovarian cancer. PMID: 27738346
19. Study of IL-23 showed reduced levels of expression in aged humans compared to young. PMID: 28509479
20. IL-23 activates gammadelta T cells in early stage PNS, which amplifies the Th17 cell population and leads to kidney injury through the secretion of IL-21. PMID: 29119640
21. serum IL-23 levels reflect obstructive sleep apnea syndrome -related systemic inflammation and are a useful marker for improvement following continuous positive airway pressure therapy PMID: 27665460
22. This study is the first to demonstrate an effect of HIV on the IL-23 signaling pathway in Th17 cells. We show that in vitro and in vivo HIV infection results in impaired IL-23 signaling which is not reversed by HAART nor is it a result of reduced receptor expression, suggesting that HIV interferes with IL-23-activated signaling pathways PMID: 29091911
23. We conclude that variants in IL-23A and IL-23R genes were associated with the risk of multiple sclerosis or other inflammatory demyelinating diseases. PMID: 27893410
24. results confirm the role of IFN-gamma and support the involvement of IL-23/Th17-related cytokines in BCC pathogenesis and in the inflammatory response during IMQ and MAL-PDT treatments PMID: 28829805
25. An increase in CSF mean levels of IL-23 was observed in amyotrophic lateral sclerosis patients. PMID: 27245439
26. results show that IL-23 accounts for the main aspects of human and murine lupus including the expansion of double negative T cells, decreased IL-2, and increased IL-17 production PMID: 28646040
27. Serum Levels of IL-17A and IL-23 Are Associated with Decreased Vitamin D3 and Increased Pain in Osteoarthritis PMID: 27820818
28. this study shows that latent cytomegalovirus induces IL-23. IL-23 might be an inflammatory mediator of latent cytomegalovirus infection in patients with rnd-stage renal diseases, and predisposes patients for post-transplant cytomegalovirus reactivation PMID: 27716059
29. These finding may provide a molecular mechanism involved in sustained ER stress in AS BdCs stimulates the activation of RUNX2 and C/EBPbeta genes, leading to IL-23 production. PMID: 28728847
30. The link between increased expression of TH17 pathway cytokines and clinical disease severity raises the possibility of a new therapeutic paradigm of targeted IL-17/IL-23 intervention for patients with ichthyosis PMID: 27554821
31. this study shows that elevated iserum IL-23 is associated with mortality in chronic hepatitis B virus, acute-on-chronic liver failure patients, and that IL-23 neutralizing antibodies attenuated liver injury by reducing the expression of Th17-related inflammatory cytokines, neutrophil chemoattractants and stabilization factors within the liver tissue PMID: 28282579
32. this study shows that IL-23 promotes IL-17+IFN-gamma- T cell expansion in multi-drug-resistant tuberculosis PMID: 27681197
33. our results suggest that IL-39 induces differentiation and/or expansion of neutrophils in lupus-prone mice. PMID: 27400195
34. The results of this case-control study suggest that IL-12A, IL-12B, IL12RB1, IL12RB2 and IL23R make no genetic contribution to the susceptibility of Takayasu arteritis in Chinese populations PMID: 26987707
35. High IL-23 expression is associated with polycystic ovary syndrome. PMID: 27146815
36. this study shows that for pre-school children with history and physical exam in favor of asthma which cannot be tested by spirometry, IL-23 serum levels may be an auxiliary biomarker for the diagnosis of asthma PMID: 28341820
37. Data show that the number of interleukin 17 (IL-17) positive cells significantly correlated positively with the number of interleukin-23 (IL-23) positive cells in skin PMID: 27388654
38. Interleukin 17A (Il17a) and interleukin-23 (IL-23) - dependent interleukin-17 Receptor C (IL-17RC) are expressed by sputum and neutrophils in deltaF508-CFTR protein (F508del) cystic fibrosis patients. PMID: 27155366
39. suberoylanilide hydroxamic acid significantly inhibited IL-12p40 and IL-23p19 mRNA synthesis and did not change IL-12p35 mRNA transcription. PMID: 27240992
40. this study shows that single nucleotide polymorphisms of the IL23R-IL12RB2 region are associated with Behcet's disease in a Northern Chinese Han population PMID: 27660093
41. this study shows that double-negative T cells from systemic lupus erythematosus patients are more expanded when stimulated in vitro with recombinant IL-23 than controls PMID: 27343994
42. Increased expression of interleukin-23 associated with progression of colorectal cancer. PMID: 27807862
43. The levels of IL-17, one of the major effector cytokines of the Th17 system, and IL-23, which had been implicated in the generation, survival and expansion of Th17 cells, are altered in Hashimoto's thyroiditis (HT). PMID: 26928603
44. Intracellular p19 associated with the cytokine receptor subunit gp130 and stimulated the gp130-dependent activation of signal transducer and activator of transcription 3 (STAT3) signaling PMID: 26980441
45. may role in the pathogenesis of arthritis and may be a useful biomarker for the diagnosis of this disease PMID: 26709220
46. we showed that elevated IL-17/IL-23 serum concentrations helped to discriminate BP patients who later relapsed. PMID: 26656739
47. The expression of IL-23 significantly increased in chronic atrophic gastritis with intestinal metaplasia tissues and gastric cancer tissues. PMID: 27053620
48. that consumption of star fruit juice at 100g twice daily for one month can significantly depress the pro-inflammation cytokines: TNF-alpha, IL-23, and NO, while increasing walking distance. PMID: 26952371
49. IL-23 mediates the differentiation of Th17 and Treg cells and the production of associated cytokines in DICs. The potential mechanism likely involves the STAT3 pathway. PMID: 26657845
50. Clostridium difficile toxins A and B induce IL-23 mRNA expression in human dendritic cells. PMID: 25626905
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亞細(xì)胞定位：

Secreted. Note=Secreted upon association with IL12B.
蛋白家族：

IL-6 superfamily
組織特異性：

Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
數(shù)據(jù)庫(kù)鏈接：

HGNC: 15488

OMIM: 605580

KEGG: hsa:51561

STRING: 9606.ENSP00000228534

UniGene: Hs.382212

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