JAK2
JAK2，即Janus激酶2，別名Janus kinase 2 、JTK10、THCYT3。它是一種細(xì)胞質(zhì)中的非受體型酪氨酸蛋白激酶，廣泛分布于體細(xì)胞的胞質(zhì)中，參與造血和免疫系統(tǒng)等的信號(hào)轉(zhuǎn)導(dǎo)，對(duì)紅細(xì)胞的生成及免疫細(xì)胞的活化也有重要作用。JAK2的作用機(jī)制主要是通過與多種細(xì)胞因子受體相關(guān)聯(lián)，當(dāng)細(xì)胞因子與其受體結(jié)合后，JAK2被激活并觸發(fā)下游的JAK-STAT信號(hào)通路，參與細(xì)胞的增殖、分化、凋亡及免疫調(diào)節(jié)等眾多生物學(xué)過程。JAK2的異常激活與多種血液系統(tǒng)惡性腫瘤的發(fā)生發(fā)展有關(guān)，尤其是與骨髓增殖性腫瘤(myeloproliferative neoplasms, MPNs)密切相關(guān)，JAK2激酶的突變，如假激酶區(qū)V617F的位點(diǎn)突變，是誘發(fā)MPNs的重要原因。AK2是治療MPNs的重要靶標(biāo)，通過抑制JAK2-STAT信號(hào)通路的異常激活來治療MPNs已成為熱門研究方向。
熱銷產(chǎn)品
Recombinant Human Tyrosine-protein kinase JAK2 (JAK2), partial (CSB-EP011931HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP011931HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) JAK2.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP011931HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) JAK2.
JAK2 Recombinant Monoclonal Antibody (CSB-RA267127A0HU)
驗(yàn)證數(shù)據(jù)
Immunofluorescence staining of Hela Cells with CSB-RA267127A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
JAK2 Antibodies
JAK2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011931LA01HU | JAK2 Antibody | Human | ELISA |
| CSB-PA951532 | Phospho-JAK2 (Tyr1007) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA202109 | JAK2 (Ab-1007) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA264562 | JAK2 (Ab-570) Antibody | Human,Rat | ELISA,IHC |
| CSB-PA173118 | Phospho-JAK2 (Tyr221) Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA227783 | Phospho-JAK2 (Tyr931) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA212456 | Phospho-JAK2 (Tyr570) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA281490 | JAK2 (Ab-570) Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA000562 | Phospho-JAK2 (Y1007) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA003078 | JAK2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA003079 | JAK2 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA011286 | Phospho-JAK2 (Y570) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA011287 | Phospho-JAK2 (Y221) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA011288 | Phospho-JAK2 (Y931) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA011289 | Phospho-JAK2 (Y119) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA011290 | JAK2 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA011291 | JAK2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA164401 | JAK2 Antibody | Human,Rat | ELISA,IHC |
| CSB-PA435870 | JAK2 Antibody | Human,Rat | ELISA,IHC |
| CSB-PA406975 | JAK2 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-MA181103 | JAK2 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-MA780030 | JAK2 Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA011931A100phHU | Phospho-JAK2 (Y1007 + Y1008) Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IP |
| CSB-RA267127A0HU | JAK2 Recombinant Monoclonal Antibody | Human | ELISA, IF |
JAK2 Proteins
JAK2 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011931PI CSB-EP011931PI CSB-BP011931PI CSB-MP011931PI CSB-EP011931PI-B |
Recombinant Pig Tyrosine-protein kinase JAK2 (JAK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
JAK2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP011931HU CSB-BP011931HU CSB-MP011931HU CSB-EP011931HU-B |
Recombinant Human Tyrosine-protein kinase JAK2 (JAK2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP011931HU | Recombinant Human Tyrosine-protein kinase JAK2 (JAK2), partial | E.coli |
JAK2 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP716150PYX CSB-EP716150PYX CSB-BP716150PYX CSB-MP716150PYX CSB-EP716150PYX-B |
Recombinant Pongo abelii Tyrosine-protein kinase JAK2 (JAK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
JAK2 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP717274RA CSB-EP717274RA CSB-BP717274RA CSB-MP717274RA CSB-EP717274RA-B |
Recombinant Rat Tyrosine-protein kinase JAK2 (Jak2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
JAK2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP726782MO CSB-EP726782MO CSB-BP726782MO CSB-MP726782MO CSB-EP726782MO-B |
Recombinant Mouse Tyrosine-protein kinase JAK2 (Jak2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
JAK2 Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP745061CH CSB-EP745061CH CSB-BP745061CH CSB-MP745061CH CSB-EP745061CH-B |
Recombinant Chicken Tyrosine-protein kinase JAK2 (JAK2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
