重癥肌無力（Myasthenia Gravis, MG）是一種罕見的慢性自身免疫性神經(jīng)肌肉疾病，由致病性免疫球蛋白G（IgG）抗體攻擊神經(jīng)肌肉接頭突觸后成分（如乙酰膽堿受體AChR、肌肉特異性酪氨酸激酶MuSK等）引發(fā)，導(dǎo)致神經(jīng)信號(hào)傳遞障礙，臨床表現(xiàn)為波動(dòng)性肌無力和易疲勞性，常累及眼肌、延髓肌及肢體肌肉，嚴(yán)重時(shí)可致呼吸衰竭。約85%的患者為全身型（gMG），其中AChR抗體陽性占主導(dǎo)（80%），MuSK抗體陽性者癥狀更重。該病發(fā)病機(jī)制涉及抗體介導(dǎo)的補(bǔ)體激活（如C5介導(dǎo)膜攻擊復(fù)合物形成）及FcRn受體對(duì)致病性IgG的再循環(huán)維持，導(dǎo)致持續(xù)自身免疫損傷。
重癥肌無力（MG）的藥物研發(fā)進(jìn)展近年來聚焦于靶向致病抗體清除和補(bǔ)體通路調(diào)控兩大核心機(jī)制，形成了以FcRn抑制劑和補(bǔ)體C5抑制劑為主流的治療格局：
● FcRn靶點(diǎn)藥物通過阻斷FcRn-IgG結(jié)合加速致病抗體降解，成為當(dāng)前最活躍的研發(fā)方向。代表藥物包括艾加莫德（efgartigimod，全球首款FcRn抑制劑）、羅澤利昔珠單抗（rozanolixizumab，2025年3月國內(nèi)獲批）、尼卡利單抗（nipocalimab，2025年4月FDA獲批）等。
● 補(bǔ)體C5抑制劑則通過阻斷補(bǔ)體級(jí)聯(lián)末端減少膜攻擊復(fù)合物形成，代表藥物為瑞利珠單抗（ravulizumab，2025年4月國內(nèi)獲批）。
未來重癥肌無力（MG）的藥物將從廣譜免疫抑制向精準(zhǔn)靶向演進(jìn)，F(xiàn)cRn與C5抑制劑已占據(jù)當(dāng)前創(chuàng)新藥的67%，而雙靶點(diǎn)藥物及無需化療的CAR-T療法有望進(jìn)一步突破難治性患者治療瓶頸。
重癥肌無力在研藥物靶點(diǎn)
重癥肌無力藥物靶點(diǎn)相關(guān)產(chǎn)品推薦
● 靶點(diǎn)蛋白
CD40
CSB-MP004936HU1
CSB-MP004936HU1
Measured by its binding ability in a functional ELISA. Immobilized CD40 at 2 μg/ml can bind CD40L (CSB-MP004937HU3), the EC50 is 3.112-3.858 ng/ml.
CLEC4C
CSB-MP855470HUh7
CSB-MP855470HUh7
Measured by its binding ability in a functional ELISA. Immobilized Human CLEC4C at 2μg/mL can bind Anti-CLEC4C recombinant antibody(CSB-RA855470MA1HU)，the EC50 is 7.658-12.99 ng/mL.
MS4A1
CSB-MP015007HU
CSB-MP015007HU
Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL.
TNFSF13B
CSB-MP897523HU1-B
CSB-MP897523HU1-B
Measured by its binding ability in a functional ELISA. Immobilized human BCMA (CSB-MP023974HU1) at 5 μg/ml can bind Biotinylated human TNFSF13B, the EC50 is 0.1752-0.3657 ng/ml.
| Target | Product Name | Source | Tag Info | Code |
|---|---|---|---|---|
| ACHE | Recombinant Bovine Acetylcholinesterase (ACHE) | E.coli | N-terminal GST-tagged | CSB-EP001154BO |
| Ache | Recombinant Rat Acetylcholinesterase (Ache) | E.coli | N-terminal 6xHis-tagged | CSB-EP001154RA |
| ACHE | Recombinant Human Motor neuron and pancreas homeobox protein 1 (ACHE) | Mammalian cell | C-terminal 10xHis-tagged | CSB-MP001154HU |
| ACHE | Recombinant Human Motor neuron and pancreas homeobox protein 1（ACHE) | Mammalian cell | C-terminal hFc-tagged | CSB-MP001154HUd9 |
| Afp | Recombinant Mouse Alpha-fetoprotein (Afp) | E.coli | N-terminal 6xHis-tagged | CSB-EP001421MO |
| Afp | Recombinant Mouse Alpha-fetoprotein (Afp) | E.coli | Tag-Free | CSB-EP001421MOe1 |
| afp | Recombinant Aspergillus giganteus Antifungal protein (afp) | E.coli | N-terminal 6xHis-B2M-tagged | CSB-EP325933APN |
| Afp | Recombinant Mouse Alpha-fetoprotein (Afp) | Yeast | N-terminal 6xHis-tagged | CSB-YP001421MO |
| Afp | Recombinant Rat Alpha-fetoprotein (Afp) | E.coli | C-terminal 6xHis-tagged | CSB-EP001421RA |
| BTK | Recombinant Human Tyrosine-protein kinase BTK (BTK) | Baculovirus | N-terminal 10xHis-tagged | CSB-BP002867HU(A4) |
| BTK | Recombinant Human Tyrosine-protein kinase BTK (BTK) | Yeast | N-terminal 6xHis-tagged | CSB-YP002867HU |
| BTK | Recombinant Human Tyrosine-protein kinase BTK (BTK), partial | E.coli | Tag-Free | CSB-EP002867HU1 |
| C1S | Recombinant Human Complement C1s subcomponent (C1S) | E.coli | N-terminal 10xHis-tagged | CSB-EP003657HU |
| C3 | Recombinant Mouse Complement C3 (C3), partial | E.coli | N-terminal 6xHis-SUMO-tagged | CSB-EP365507MO |
| C3 | Recombinant Bovine Complement C3 (C3), partial | E.coli | N-terminal 6xHis-SUMO-tagged | CSB-EP647263BO |
| C3 | Recombinant Human Complement C3 (C3), partial | E.coli | N-terminal 6xHis-tagged | CSB-EP355590HU |
| C3 | Recombinant Rat Complement C3 (C3), partial | Yeast | N-terminal 6xHis-tagged | CSB-YP360475RA |
| C5 | Recombinant Human Complement C5 (C5), partial | E.coli | N-terminal 6xHis-SUMO-tagged | CSB-EP003995HU |
| C5 | Recombinant Rat Complement C5 (C5) | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-EP003995RA |
| C5 | Recombinant Human Complement C5 (C5), partial | Mammalian cell | N-terminal 6xHis-Myc-tagged | CSB-MP003995HU |
● 抗體
C3 Recombinant Monoclonal Antibody
CSB-RA303909A0HU
CSB-RA303909A0HU
Tested Applications:
ELISA, WB, IHC, FC
CD19 Recombinant Monoclonal Antibody
CSB-RA780821A0HU
CSB-RA780821A0HU
Tested Applications:
ELISA, WB, IHC, IP
CD38 Recombinant Monoclonal Antibody
CSB-RA796695A0HU
CSB-RA796695A0HU
Tested Applications:
ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU
CSB-RA159341A0HU
Tested Applications:
ELISA, IHC, IF, FC
- 重組抗體
| Target | Product Name | Species Reactivity | Tested Applications | Code |
|---|---|---|---|---|
| BTK | BTK Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA553167A0HU |
| C3 | C3 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, FC | CSB-RA303909A0HU |
| C3 | C3 Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA699863A0HU |
| C5 | C5 Recombinant Monoclonal Antibody | Human | ELISA, FC | CSB-RA003995MA1HU |
| CD19 | CD19 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA004888A0HU |
| CD19 | CD19 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IP | CSB-RA780821A0HU |
| CD19 | CD19 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB | CSB-RA004888MA1HU |
| CD38 | CD38 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC | CSB-RA796695A0HU |
| CD4 | CD4 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC | CSB-RA004935A0HU |
| CD40 | CD40 Recombinant Monoclonal Antibody | Human | ELISA, IF, FC | CSB-RA004936MA1HU |
| CLEC4C | CLEC4C Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA855470MA1HU |
| EGFR | Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | Human | ELISA, WB | CSB-RA007479A1092phHU |
| EGFR | Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | Human | ELISA, WB | CSB-RA007479A1068phHU |
| EGFR | EGFR Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC | CSB-RA159341A0HU |
| EGFR | EGFR Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC | CSB-RA794061A0HU |
| EGFR | EGFR Recombinant Monoclonal Antibody | Human | ELISA, IHC, FC | CSB-RA159341MA1HU |
| MS4A1 | CD20 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA015007A0HU |
| MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA015007A1HU |
| MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human, Dog, Macaca fascicularis | ELISA | CSB-RA015007MA3HU |
| MS4A1 | MS4A1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF | CSB-RA015007MA4HU |
- 單克隆抗體
| Target | Product Name | Species Reactivity | Tested Applications | Code |
|---|---|---|---|---|
| AFP | AFP Monoclonal Antibody | Human | ELISA, IHC | CSB-MA027711A0m |
| AFP | AFP Monoclonal Antibody | Human | ELISA, IHC | CSB-MA027711E0m |
| AFP | AFP Monoclonal Antibody | Human | ELISA, WB | CSB-MA000233 |
| AFP | AFP Monoclonal Antibody | Human | ELISA, WB | CSB-MA099203 |
| CD19 | CD19 Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC | CSB-MA004888A0m |
| CD19 | CD19 Monoclonal Antibody | Human | ELISA, WB, IHC, FC | CSB-MA004888A1m |
| CD19 | CD19 Monoclonal Antibody,APC Conjugated | Human | ELISA, IF, FC | CSB-MA195220 |
| CD19 | CD19 Monoclonal Antibody,Biotin Conjugated | Human | ELISA, IF, FC | CSB-MA899608 |
| CD19 | CD19 Monoclonal Antibody,FITC Conjugated | Human | ELISA, IF, FC | CSB-MA047662 |
| CD19 | CD19 Monoclonal Antibody,PE Conjugated | Human | ELISA, IF, FC | CSB-MA036486 |
| CD19 | CD19 Monoclonal Antibody,PE-Cy5 Conjugated | Human | ELISA, IF, FC | CSB-MA281869 |
| CD19 | CD19 Monoclonal Antibody,Purified | Human | ELISA, FC | CSB-MA798261 |
| CD38 | CD38 Monoclonal Antibody | Human | ELISA, IHC | CSB-MA785760 |
| CD4 | CD4 Monoclonal Antibody | Human,Mouse,Rat | ELISA, IHC | CSB-MA000228 |
| CD4 | CD4 Monoclonal Antibody,APC Conjugated | Human | ELISA, IF, FC | CSB-MA043428 |
| CD4 | CD4 Monoclonal Antibody,Biotin Conjugated | Human | ELISA, IF, FC | CSB-MA981329 |
| CD4 | CD4 Monoclonal Antibody,FITC Conjugated | Human | ELISA, IF, FC | CSB-MA124048 |
| CD4 | CD4 Monoclonal Antibody,PE Conjugated | Human | ELISA, IF, FC | CSB-MA260243 |
| CD4 | CD4 Monoclonal Antibody,PE-Cy5 Conjugated | Human | ELISA, IF, FC | CSB-MA570802 |
| CD4 | CD4 Monoclonal Antibody,Purified | Human | ELISA, FC | CSB-MA783233 |
- 多克隆抗體
| Target | Product Name | Species Reactivity | Tested Applications | Code |
|---|---|---|---|---|
| ACHE | ACHE Antibody | Human | ELISA, IHC, IF | CSB-PA5619A0Rb |
| ache | ache Antibody | Zebrafish | ELISA, WB | CSB-PA863598LA01DIL |
| ACHE | ACHE Antibody | Human, Mouse, Rat | ELISA, WB, IHC | CSB-PA010202 |
| ACHE | ACHE Antibody | Human, Mouse, Rat | ELISA, WB | CSB-PA010203 |
| ACHE | ACHE Antibody | Human, Mouse, Rat | ELISA, WB | CSB-PA001154GA01HU |
| ACHE | ACHE Antibody | Human, Mouse, Rat | ELISA, WB | CSB-PA904467 |
| ACHE | ACHE Antibody | Human, Mouse, Rat | ELISA, WB, IHC | CSB-PA114463 |
| ACHE | ACHE Antibody | Human | ELISA, WB | CSB-PA547258 |
| AFP | AFP Antibody | Human | ELISA, IHC | CSB-PA09987A0Rb |
| AFP | AFP Antibody | Human | ELISA, WB | CSB-PA09989A0Rb |
| afp | afp Antibody | Aspergillus giganteus | ELISA | CSB-PA325933LA01APN |
| AFP | AFP Antibody | Human | ELISA, WB | CSB-PA004875 |
| AFP | AFP Antibody | Human, Mouse, Rat | ELISA, WB, IHC | CSB-PA001421GA01HU |
| AFP | AFP Antibody | Human | ELISA, WB, IHC | CSB-PA251527 |
| AFP | AFP Antibody | Human | ELISA, WB, IHC | CSB-PA787484 |
| AFP | AFP Antibody | Human | ELISA, IHC | CSB-PA145342 |
| AFP | AFP Antibody | Human | ELISA, WB, IHC | CSB-PA230953 |
| AFP | AFP Antibody | Human | ELISA, WB | CSB-PA075526 |
| BTK | BTK Antibody | Human, Mouse | ELISA, WB, IHC, IF | CSB-PA002867LA01HU |
| BTK | Phospho-BTK (Y223) Antibody | Human, Mouse, Rat | ELISA, WB | CSB-PA000638 |
● ELISA試劑盒
Rat Acetylcholinesterase, AChE ELISA Kit
CSB-E11304r
Fish Acetylcholinesterase (AChE) ELISA Kit
CSB-E17001Fh
Rat Complement fragment 5,C5 ELISA Kit
CSB-E14363r
| Target | Product Name | Sample Types | Detection Range | Code |
|---|---|---|---|---|
| ACHE | Rat Acetylcholinesterase,AChE ELISA Kit | serum, plasma, tissue homogenates | 7.8 pg/mL-500 pg/mL | CSB-E11304r |
| AChE | Fish Acetylcholinesterase(AChE)ELISA Kit | serum, plasma, tissue homogenates | 2.5 ng/mL-40 ng/mL | CSB-E17001Fh |
| ACHE | Human Acetylcholinesterase,AChE ELISA Kit | serum, plasma, tissue homogenates | 0.94 mU/mL-60 mU/mL | CSB-E09670h |
| AChE | Mouse Acetylcholinesterase(AChE)ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 0.312 mU/mL-20 mU/mL | CSB-E17521m |
| AFP | Human Alpha-fetoprotein,AFP ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 1.563 ng/mL-100 ng/mL | CSB-E04770h |
| AFP | Rat Alpha-fetoprotein,AFP ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 15.6 pg/mL-1000 pg/mL | CSB-E08281r |
| AFP | Mouse Alpha-fetoprotein,AFP ELISA Kit | serum, plasma, tissue homogenates. | 1.23 ng/ml-900 ng/ml. | CSB-E08282m |
| AFP | Pig Alpha-fetoprotein(AFP) ELISA kit | serum, plasma, tissue homogenates, cell culture supernates | 3.12 ng/mL-200 ng/mL | CSB-EL001421PI |
| C1S | Human Complement C1s subcomponent(C1S) ELISA kit | serum, plasma, tissue homogenates | 25 ng/mL-1600 ng/mL | CSB-EL003657HU |
| C3 | Fish Complement 3,C3 ELISA Kit | serum, plasma | 12.5 μg/mL-500 μg/mL | CSB-E09727s |
| C3 | Human Complement 3,C3 ELISA Kit | serum, plasma, cell culture supernates, urine, saliva | 4.7 ng/mL-300 ng/mL | CSB-E08665h |
| C3 | Rat Complement 3,C3 ELISA Kit | serum, plasma, tissue homogenates | 0.625 μg/mL-40 μg/mL | CSB-E08666r |
| C3 | Pig Complement 3,C3 ELISA Kit | serum, plasma, tissue homogenates | 0.625 μg/mL-10 μg/mL | CSB-E06920p |
| C3 | Mouse Complement 3,C3 ELISA Kit | serum, plasma, tissue homogenates | 93.75 ng/mL-6000 ng/mL | CSB-E08667m |
| C3 | Rabbit Complement 3,C3 ELISA Kit | serum, plasma | 27.3 ng/mL-7000 ng/mL | CSB-E08668Rb |
| C3 | Dog Complement 3(C3)ELISA Kit | serum, plasma, tissue homogenates | 0.78 μg/mL-50 μg/mL | CSB-EL003888DO |
| C3 | Monkey Complement 3(C3)ELISA Kit | serum, plasma, cell culture supernates | 4.68 ng/mL-300 ng/mL | CSB-E16528Mk |
| C5 | Rat Complement fragment 5,C5 ELISA Kit | serum, plasma, tissue homogenates | 9.38 ng/mL-600 ng/mL | CSB-E14363r |
| C5 | Mouse Complement 5,C5 ELISA Kit | serum, plasma, tissue homogenates | 0.25 ng/mL-16 ng/mL | CSB-E13802m |
| C5 | Monkey complement C5 (C5) ELISA kit | serum, plasma, tissue homogenates | 0.625 ng/mL-40 ng/mL | CSB-EL003995MK |
