MUC17 Recombinant Monoclonal Antibody

說明書

中文名稱：

MUC17重組抗體
貨號：

CSB-RA727848MA1HU
規格：

￥1320
圖片：
The Binding Activity of Human MUC17 with Anti-MUC17 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MUC17 (CSB-MP727848HU) at 2 μg/mL can bind Anti-MUC17 recombinant antibody. The EC₅₀ is 0.9057-1.259 ng/mL.

The purity of MUC17 was greater than 95% as determined by SEC-HPLC
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靶點詳情

產品詳情

產品描述：

CSB-RA727848MA1HU MUC17重組單克隆抗體是經ELISA驗證的高特異性科研工具，靶向黏蛋白家族成員MUC17。該跨膜糖蛋白在胃腸道上皮屏障保護和細胞信號調控中發揮重要作用，其異常表達與消化系統病理過程密切相關。本抗體通過重組技術制備，具備優異的重現性和批次穩定性，適用于定量ELISA檢測體系，可精準識別天然構象的MUC17蛋白。實驗數據顯示其在抗原識別中展現高親和力與低交叉反應性，能夠有效支持基礎研究中的蛋白表達水平分析、病理機制探索及相關信號通路研究。該產品特別適用于胃腸道疾病模型構建、腫瘤微環境分析以及黏蛋白功能組學研究，為探討MUC17在細胞黏附、分化及免疫調節中的作用提供可靠檢測工具，滿足分子互作研究和生物標志物篩選等科研需求。
Uniprot No.：

Q685J3
基因名：

MUC17
別名：

Mucin-17, MUC-17, Small intestinal mucin-3 (MUC-3), MUC17, MUC3
反應種屬：

Human
免疫原：

Recombinant Human MUC17 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Human IgG
純化方式：

Affinity-chromatography
克隆號：

8D12
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Probably plays a role in maintaining homeostasis on mucosal surfaces.
基因功能參考文獻：
1. MUC17 polymorphisms are involved in endometriosis development and the associated infertility in the Taiwanese population. PMID: 26285705
2. Carbachol stimulated enterocyte MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment. PMID: 23784542
3. The HIF1alpha-mediated hypoxic signal pathway contributes to MUC17 expression, and DNA methylation of hypoxia responsive element could be a determinant of the hypoxic inducibility of MUC17 in pancreatic cancer cells. PMID: 22970168
4. Both native and exogenous MUC17 play a role in attachment and invasion of enteroinvasive E. coli in colonic cell lines and in maintaining epithelial barrier function. PMID: 21393431
5. Hypomethylation status in the MUC17 promoter could be a novel epigenetic marker for the diagnosis of Pancreatic ductal adenocarcinomas. PMID: 20926598
6. Results indicate that the potential protective effects of this membrane-bound mucin are primarily or secondarily diminished in inflammatory and neoplastic conditions. PMID: 20702471
7. augments intestinal cell restitution and enhances healing of experimental colitis in mice PMID: 20211273
8. The authors demonstrate that apically atypical enteropathogenic Escherichia coli infection is followed by increased production of secreted MUC2 and MUC5AC mucins and membrane-bound MUC3 and MUC4 mucins. PMID: 20065027
9. sequence homology & chromosome mapping PMID: 11855812
10. surface localization of the smaller subunit of MUC17 is dependent on its N-glycosylation status PMID: 12888891
11. The MUC17 sequence has been extended toward its 5'-extremity to complete the sequence and localize the promoter and regulatory elements. PMID: 16737958
12. Pdzk1 plays a specific role in stabilizing Muc17 in the apical membrane of small intestinal enterocytes. PMID: 17990980
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亞細胞定位：

[Isoform 1]: Cell membrane; Single-pass membrane protein.; [Isoform 2]: Secreted. Cell membrane.
組織特異性：

Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in panc
數據庫鏈接：

HGNC: 16800

OMIM: 608424

KEGG: hsa:140453

STRING: 9606.ENSP00000302716

UniGene: Hs.271819

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