世界白癜風(fēng)日（World Vitiligo Day）設(shè)立于每年的6月25日，這一天是為了紀(jì)念已故流行音樂天王邁克爾·杰克遜，他的公眾形象變化曾引起廣泛討論，但實(shí)際上他患有嚴(yán)重的白癜風(fēng)，這一疾病的誤解促使人們設(shè)立了這個紀(jì)念日，以提高全球?qū)Π遵帮L(fēng)這一皮膚病的認(rèn)識、理解與關(guān)注。
白癜風(fēng)（vitiligo）是一種常見的色素脫失性疾病，其特征是皮膚及（或）毛發(fā)出現(xiàn)局部或廣泛性的白色斑塊，這是由于皮膚內(nèi)的黑色素細(xì)胞受損或消失所導(dǎo)致。黑色素細(xì)胞負(fù)責(zé)產(chǎn)生黑色素，這是一種賦予皮膚、眼睛和頭發(fā)顏色的色素。白癜風(fēng)可影響所有種族人群，且男女患病率相近，盡管任何年齡都可能發(fā)病，但多見于青少年時期。
白癜風(fēng)的發(fā)病機(jī)制尚未完全明了，但目前的研究認(rèn)為其發(fā)病涉及遺傳、自身免疫、氧化應(yīng)激、神經(jīng)因素等多種復(fù)雜機(jī)制的相互作用。
目前，國內(nèi)外對于白癜風(fēng)的研究已經(jīng)取得了一些重要突破。例如，前期研究發(fā)現(xiàn)，白癜風(fēng)患者中的Nrf2信號通路的活性顯著降低，導(dǎo)致黑色素細(xì)胞更易受損。Nrf2是機(jī)體抵御氧化應(yīng)激反應(yīng)的主要調(diào)節(jié)因子，能夠保護(hù)過氧化氫誘導(dǎo)的黑素細(xì)胞凋亡。因此，激活Nrf2通路成為一種重要的治療策略。
近年來，白癜風(fēng)的治療靶點(diǎn)研究仍在不斷拓展，不再局限于JAK抑制劑。研究人員發(fā)現(xiàn)IFN-γ對白癜風(fēng)皮膚黑素細(xì)胞具有直接毒性作用，提示人抗IFN-γ單克隆抗體在白癜風(fēng)治療中擁有潛在應(yīng)用價值。此外，國內(nèi)團(tuán)隊(duì)發(fā)現(xiàn)抑制MIF可改善白癜風(fēng)小鼠的疾病進(jìn)展，有望成為白癲風(fēng)治療的新靶點(diǎn)。
華美生物長期致力于為科研工作者提供高質(zhì)量的蛋白、抗體、ELISA試劑盒等工具類科研試劑產(chǎn)品，鑒于白癜風(fēng)研究的重要性與迫切性，在此特別整理了一系列與白癜風(fēng)研究相關(guān)的20余種熱門靶點(diǎn)及相關(guān)試劑產(chǎn)品列舉如下，供您選擇：
白癜風(fēng)研究相關(guān)ELISA試劑盒：
| 產(chǎn)品名稱 | 貨號 | 靶點(diǎn) | 檢測范圍 | 靈敏度 |
|---|---|---|---|---|
| 大鼠過氧化氫酶(CAT)酶聯(lián)免疫試劑盒 | CSB-E13439r | CAT | 93.75 mIU/mL-6000 mIU/mL | 23.43 mIU/mL |
| 人過氧化氫酶(CAT)酶聯(lián)免疫試劑盒 | CSB-E13635h | CAT | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
| 小鼠過氧化氫酶(CAT)酶聯(lián)免疫試劑盒 | CSB-E14190m | CAT | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
| 魚過氧化氫酶(CAT)酶聯(lián)免疫試劑盒 | CSB-E15928Fh | CAT | 125 mU/mL-2000 mU/mL | 62.5 mU/mL |
| 人CD4分子(CD4)酶聯(lián)免疫試劑盒 | CSB-E08956h | CD4 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
| 大鼠CD4分子(CD4)酶聯(lián)免疫試劑盒 | CSB-E12928r | CD4 | 0.78 U/mL-50 U/mL | 0.195 U/mL |
| 雞CD4分子(CD4)酶聯(lián)免疫試劑盒 | CSB-E13114C | CD4 | 3.125 ng/mL-800 ng/mL | 3.125 ng/mL |
| 人CD8分子(CD8)酶聯(lián)免疫試劑盒 | CSB-E12707h | CD8A | 62.5 U/mL-4000 U/mL | 15.6 U/mL |
| 人細(xì)胞毒性T淋巴細(xì)胞相關(guān)抗原4(CTLA-4/CD152)酶聯(lián)免疫試劑盒 | CSB-E09171h | CTLA4 | 125 pg/mL-8000 pg/mL | 31.25 pg/mL |
| 小鼠細(xì)胞毒性T淋巴細(xì)胞相關(guān)抗原4(CTLA-4/CD152)酶聯(lián)免疫試劑盒 | CSB-E13637m | CTLA4 | 0.312 ng/mL-20 ng/mL | 0.078 ng/mL |
| 人干擾素誘導(dǎo)蛋白10(IP-10/CXCL10)酶聯(lián)免疫試劑盒 | CSB-E08181h | CXCL10 | 31.25 pg/mL-2000 pg/mL | 7.8 pg/mL |
| 大鼠干擾素誘導(dǎo)蛋白10(IP-10/CXCL10)酶聯(lián)免疫試劑盒 | CSB-E08182r | CXCL10 | 781.25 pg/mL-50000 pg/mL | 195 pg/mL |
| 小鼠干擾素誘導(dǎo)蛋白10(IP-10/CXCL10)酶聯(lián)免疫試劑盒 | CSB-E08183m | CXCL10 | 0.312 ng/ml - 20 ng/ml | 0.078 ng/ml |
| 猴C-X-C趨化因子10(CXCL10)酶聯(lián)免疫試劑盒 | CSB-EL006240RH | CXCL10 | 62.5 pg/mL-4000 pg/mL | 15.6 pg/mL |
| 人白介素8(IL-8/CXCL8)酶聯(lián)免疫試劑盒 | CSB-E04641h | CXCL8 | 31.25 pg/mL-2000 pg/mL | 7.110 pg/mL |
| 豬白介素8(IL-8/CXCL8)酶聯(lián)免疫試劑盒 | CSB-E06787p | CXCL8 | 125 pg/mL-8000 pg/mL | 31.25 pg/mL |
| 犬白介素8(IL-8/CXCL8)酶聯(lián)免疫試劑盒 | CSB-E08052c | CXCL8 | 0.312 ng/mL-20 ng/mL | 0.146 ng/mL |
| 兔子白介素8(IL-8/CXCL8)酶聯(lián)免疫試劑盒 | CSB-E06905Rb | CXCL8 | 23.5 pg/mL-1500 pg/mL | 5.8 pg/mL |
| 猴子白介素8(IL-8/CXCL8)酶聯(lián)免疫試劑盒 | CSB-E08051Mo | CXCL8 | 31.25 pg/mL-2000 pg/mL | 7.81 pg/mL |
| 牛白介素8(IL-8)酶聯(lián)免疫試劑盒 | CSB-E13052B | CXCL8 | 50 pg/mL-2000 pg/mL | 50 pg/mL |
白癜風(fēng)研究相關(guān)重組蛋白：
| 產(chǎn)品名稱 | 貨號 | 靶點(diǎn) | 來源 | 蛋白標(biāo)簽 |
|---|---|---|---|---|
| Recombinant Macaca mulatta Interleukin-10 (IL10) | CSB-BP011580MOW | IL10 | Baculovirus | N-terminal 10xHis-tagged and C-terminal myc-tagged |
| Recombinant Macaca mulatta Interleukin-10 (IL10) | CSB-BP011580MOWd7 | IL10 | Baculovirus | C-terminal 10xHis-tagged |
| Recombinant Human Macrophage migration inhibitory factor (MIF) | CSB-BP013826HU | MIF | Baculovirus | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Recombinant Rat Transforming growth factor beta-1 proprotein (Tgfb1), partial | CSB-BP023446RA | Tgfb1 | Baculovirus | N-terminal 6xHis-tagged |
| Recombinant Marmota monax Tumor necrosis factor (TNF), partial | CSB-BP523593MQG | TNF | Baculovirus | N-terminal 10xHis-tagged |
| Recombinant Human T-cell surface glycoprotein CD4 (CD4), partial | CSB-CF004935HU1 | CD4 | in vitro E.coli expression system | N-terminal 6xHis-tagged |
| Recombinant Human C-X-C chemokine receptor type 3 (CXCR3) | CSB-CF006253HU | CXCR3 | in vitro E.coli expression system | N-terminal 6xHis-tagged |
| Recombinant Human C-X-C chemokine receptor type 3 (CXCR3) | CSB-CF006253HUb0 | CXCR3 | in vitro E.coli expression system | N-terminal 10xHis-tagged |
| Recombinant Mouse Catalase (Cat) | CSB-EP004563MO | Cat | E.coli | N-terminal 10xHis-tagged and C-terminal myc-tagged |
| Recombinant Bovine T-cell surface glycoprotein CD8 alpha chain (CD8A), partial | CSB-EP004966BO | CD8A | E.coli | N-terminal 6xHis-SUMO-tagged |
| Recombinant Human T-cell surface glycoprotein CD8 alpha chain (CD8A), partial | CSB-EP004966HU | CD8A | E.coli | N-terminal 6xHis-SUMO-tagged |
| Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial | CSB-EP006163HU1 | CTLA4 | E.coli | N-terminal 6xHis-tagged |
| Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial | CSB-EP006163MO1 | Ctla4 | E.coli | N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged |
| Recombinant Human C-X-C motif chemokine 10 (CXCL10) | CSB-EP006240HU | CXCL10 | E.coli | N-terminal 6xHis-tagged |
| Recombinant Human C-X-C motif chemokine 10 (CXCL10) | CSB-EP006240HUc7 | CXCL10 | E.coli | C-terminal 6xHis-tagged |
| Recombinant Mouse C-X-C motif chemokine 10 (Cxcl10) | CSB-EP006240MO | Cxcl10 | E.coli | N-terminal GST-tagged |
| Recombinant Human C-X-C motif chemokine 9 (Cxcl9) | CSB-EP006252HU | CXCL9 | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Recombinant Mouse C-X-C motif chemokine 9 (Cxcl9) | CSB-EP006252MO | Cxcl9 | E.coli | N-terminal 6xHis-tagged |
| Recombinant Rabbit C-X-C motif chemokine (CXCL9) | CSB-EP006252RB | CXCL9 | E.coli | N-terminal 6xHis-SUMO-tagged |
| Recombinant Human C-X-C chemokine receptor type 3 (CXCR3), partial | CSB-EP006253HU1 | CXCR3 | E.coli | N-terminal 6xHis-GST-tagged |
白癜風(fēng)研究相關(guān)抗體：
● 重組抗體：
| 產(chǎn)品名稱 | 貨號 | 靶點(diǎn) | 反應(yīng)種屬 | 應(yīng)用范圍 |
|---|---|---|---|---|
| CD4 Recombinant Monoclonal Antibody | CSB-RA004935A0HU | CD4 | Human | ELISA, WB, IHC |
| CD8A Recombinant Monoclonal Antibody | CSB-RA934881A0HU | CD8A | Human | ELISA, WB, IHC, IP |
| CTLA4 Recombinant Monoclonal Antibody | CSB-RA213310A0HU | CTLA4 | Human | ELISA, IHC |
| CTLA4 Recombinant Monoclonal Antibody | CSB-RA006163MA1HU | CTLA4 | Human, Mouse | ELISA, WB, IF, FC |
| CXCL10 Recombinant Monoclonal Antibody | CSB-RA903061A0HU | CXCL10 | Human | ELISA, IHC |
| IL10 Recombinant Monoclonal Antibody | CSB-RA011580A0HU | IL10 | Human | ELISA |
| IL17A Recombinant Monoclonal Antibody | CSB-RA624104MA1HU | IL17A | Human | ELISA |
| IL6 Recombinant Monoclonal Antibody | CSB-RA011664MA1HU | IL6 | Human | ELISA |
| JAK1 Recombinant Monoclonal Antibody | CSB-RA227790A0HU | JAK1 | Human | ELISA, IHC |
| Phospho-JAK2 (Y1007 + Y1008) Recombinant Monoclonal Antibody | CSB-RA011931A100phHU | JAK2 | Human | ELISA, WB, IHC, IP |
| JAK2 Recombinant Monoclonal Antibody | CSB-RA267127A0HU | JAK2 | Human | ELISA, IF |
| JAK3 Recombinant Monoclonal Antibody | CSB-RA206737A0HU | JAK3 | Human | ELISA, IHC |
| MIF Recombinant Monoclonal Antibody | CSB-RA146975A0HU | MIF | Human | ELISA, WB |
| PDCD1 Recombinant Monoclonal Antibody | CSB-RA240597A0HU | PDCD1 | Human | ELISA, WB, IHC |
| TYR Recombinant Monoclonal Antibody | CSB-RA567167A0HU | TYR | Human | ELISA, IF |
● 單克隆抗體：
| 產(chǎn)品名稱 | 貨號 | 靶點(diǎn) | 反應(yīng)種屬 | 應(yīng)用范圍 |
|---|---|---|---|---|
| CD4 Monoclonal Antibody | CSB-MA000228 | CD4 | Human,Mouse,Rat | ELISA, IHC |
| CD4 Monoclonal Antibody,Purified | CSB-MA783233 | CD4 | Human | ELISA, FC |
| CD8A Monoclonal Antibody,Purified | CSB-MA927984 | CD8A | Human | ELISA, FC |
| CTLA4 Monoclonal Antibody | CSB-MA006163A0m | CTLA4 | Human | ELISA, WB, IHC |
| CXCL8 Monoclonal Antibody | CSB-MA083271A0m | CXCL8 | Human | ELISA, IHC |
| IFNG Monoclonal Antibody | CSB-MA065241A0m | IFNG | Human | ELISA, IHC |
| IL1B Monoclonal Antibody | CSB-MA065741A0m | IL1B | Human | ELISA |
| IL1B Monoclonal Antibody | CSB-MA010884 | IL1B | Human | ELISA, WB, IHC, ICC |
| IL6 Monoclonal Antibody | CSB-MA067571A0m | IL6 | Human | ELISA, WB, IHC |
| JAK1 Monoclonal Antibody | CSB-MA919964 | JAK1 | Human,Mouse,Rat | ELISA, IHC |
| JAK2 Monoclonal Antibody | CSB-MA181103 | JAK2 | Human,Mouse,Rat | ELISA, IHC |
| JAK2 Monoclonal Antibody | CSB-MA780030 | JAK2 | Human,Mouse,Rat | ELISA, IHC |
| TNF Monoclonal Antibody | CSB-MA084771A0m | TNF | Bovine | ELISA |
| TNF Monoclonal Antibody | CSB-MA080271 | TNF | Human,Mouse,Rat | ELISA, WB, IHC |
| TNF Monoclonal Antibody | CSB-MA080272 | TNF | Human,Mouse,Rat | ELISA, WB, IHC |
● 多克隆抗體：
| 產(chǎn)品名稱 | 貨號 | 靶點(diǎn) | 反應(yīng)種屬 | 應(yīng)用范圍 |
|---|---|---|---|---|
| CAT Antibody | CSB-PA004980 | CAT | Human | ELISA, WB |
| Phospho-CAT (Y386) Antibody | CSB-PA070042 | CAT | Human, Mouse, Rat | ELISA, WB, IHC |
| CAT Antibody | CSB-PA070043 | CAT | Human, Mouse, Rat | ELISA, IHC |
| CAT Antibody | CSB-PA004563GA01HU | CAT | Human, Mouse, Rat | ELISA, WB, IHC |
| CAT Antibody | CSB-PA599838 | CAT | Human, Mouse, Rat | ELISA, WB, IHC |
| CAT Antibody | CSB-PA942303 | CAT | Human, Mouse, Rat | ELISA, WB, IHC |
| CD4 Antibody | CSB-PA004935ESR2HU | CD4 | Human | ELISA, IHC |
| Phospho-CD4 (S433) Antibody | CSB-PA070257 | CD4 | Human, Mouse | ELISA, IHC, IF |
| CD4 Antibody | CSB-PA001453 | CD4 | Human, Mouse | ELISA, WB, IHC, IF |
| CD4 Antibody | CSB-PA004935GA01HU | CD4 | Human, Mouse, Rat | ELISA, WB |
| CD8A Antibody | CSB-PA004966LA01HU | CD8A | Human | ELISA, IHC |
| CTLA4 Antibody | CSB-PA006163LA01HU | CTLA4 | Human | ELISA, IF |
| CTLA4 Antibody | CSB-PA252417 | CTLA4 | Human | ELISA, IHC |
| CTLA4 Antibody | CSB-PA006163KA01HU | CTLA4 | Human | ELISA, WB, IHC |
| CTLA4 Antibody | CSB-PA224600 | CTLA4 | Human, Mouse, Rat | ELISA, IHC |
| CXCL10 Antibody | CSB-PA06107A0Rb | CXCL10 | Human | ELISA |
| CXCL10 Antibody | CSB-PA822646LA01MOW | CXCL10 | Macaca mulatta | ELISA |
| CXCL10 Antibody | CSB-PA761371 | CXCL10 | Human | ELISA, IHC |
| CXCL8 Antibody | CSB-PA011671YA01DO | CXCL8 | Dog | ELISA |
| CXCL8 Antibody | CSB-PA08327A0Rb | CXCL8 | Human | ELISA, WB, IHC |
