每年11月的第三個星期三被定為世界慢性阻塞性肺疾病日（World COPD Day），始于2002年，由全球慢性阻塞性肺疾病倡議組織（GOLD）發起，旨在提高公眾對慢性阻塞性肺疾病（COPD）的認識，推動早期診斷和治療。
慢性阻塞性肺疾病（COPD），又稱慢性阻塞性肺炎，是一種具有進行性、不可逆特征的氣流受限性疾病。COPD的癥狀包括咳嗽、咳痰、呼吸困難、急性加重、胸悶、氣短等。COPD的主要風險因素包括長期吸煙、職業性粉塵和化學物質暴露等，并與多種炎癥因子有密切關系。據統計，COPD已成為世界第三大致死原因，僅次于缺血性心臟病和卒中，不僅嚴重影響患者的生活質量，還給患者個人、社會及家庭帶來了沉重的經濟負擔。
COPD的病理機制復雜，包括慢性炎癥、氧化應激、蛋白酶與抗蛋白酶失衡、細胞衰老、異常修復機制等 [1][2][3]。炎癥在疾病的發展中扮演著關鍵角色，目前的治療方法包括長效支氣管擴張劑和抗炎藥物，但這些方法并不能阻止疾病進展或解決所有問題。正在研發的新的治療靶點包括炎癥介質的調節劑、蛋白酶抑制劑、抗氧化劑、激酶抑制劑、PDE4抑制劑、NF-κB抑制劑、senolytics、抗纖維化劑等 [4]。
在治療方面，COPD領域近年來取得了顯著進展，推出了多種新藥物，包括單克隆抗體和小分子化藥。這些藥物通過靶向IL-4Rα、PDE4、PDE3、TSLP等關鍵分子，為患者提供了更多治療選擇。例如，司普奇拜單抗（Stapokibart）靶向IL-4Rα，已于2024年7月30日在中國獲批。恩塞芬汀（Ensifentrine）作為PDE3和PDE4的雙重抑制劑，于2023年3月10日在美國獲批。特澤魯單抗（Tezepelumab）作為TSLP抑制劑，于2022年1月30日在美國獲批。這些新藥的上市，不僅豐富了COPD的治療手段，也為患者帶來了更多的希望和個性化治療方案。
華美生物長期致力于為科研工作者提供高質量的蛋白、抗體、ELISA試劑盒等工具類科研試劑產品，特整理了一系列與慢性阻塞性肺疾病研究相關的熱門靶點及相關試劑產品列舉如下，供您選擇。
熱門研究靶點：
● 慢性阻塞性肺疾病研究相關重組蛋白
C5AR1
CSB-MP003996HU
CSB-MP003996HU
Measured by its binding ability in a functional ELISA. Immobilized human C5AR1 at 10 μg/ml can bind Anti-C5AR1 recombinant antibody (CSB-RA003996A0HU), the EC50 is 1.239-3.760 ng/mL
Measured by its binding ability in a functional ELISA. Immobilized Human IL4 (CSB-MP011659HU) at 2μg/mL can bind biotinylated Human IL4R，the EC50 is 12.68-14.23 ng/mL.
TNFSF13B
CSB-MP897523HU1
CSB-MP897523HU1
Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.
TSLP
CSB-MP5042MOV
CSB-MP5042MOV
-AC1.jpg)
Loaded Cynomolgus TSLP (R127A, R130S) on 96-Flat plate, can bind anti-TSLP antibody (CSB-RA025141MA1HU), with an affinity constant of 4.41 nM as determined in BLI assay (Gator Prime)
| Target | Product Name | Product Code | Source | Tag Info |
|---|---|---|---|---|
| ACVR2B | Recombinant Human Activin receptor type-2B (ACVR2B), partial | CSB-EP623829HU | E.coli | N-terminal 6xHis-B2M-tagged |
| ACVR2B | Recombinant Human Activin receptor type-2B (ACVR2B), partial | CSB-YP623829HU | Yeast | N-terminal 6xHis-tagged |
| ACVR2B | Recombinant Human Activin receptor type-2B (ACVR2B), partial (Active) | CSB-AP005701HU | Mammalian cell | C-terminal 6xHis-Fc-tagged |
| AKT1 | Recombinant Human RAC-alpha serine/threonine-protein kinase (AKT1) | CSB-EP001553HU | E.coli | N-terminal GST-tagged |
| Akt1 | Recombinant Rat RAC-alpha serine/threonine-protein kinase (Akt1) | CSB-EP001553RA | E.coli | N-terminal 10xHis-tagged |
| Alb | Recombinant Mouse Serum albumin (Alb) | CSB-BP001561MO | Baculovirus | C-terminal 9xHis-tagged |
| ALB | Recombinant Dog Serum albumin (ALB) | CSB-EP001561DO | E.coli | N-terminal 6xHis-tagged |
| ALB | Recombinant Macaca fascicularis albumin (ALB) | CSB-EP001561MOV | E.coli | N-terminal 6xHis-SUMO-tagged |
| ALB | Recombinant Macaca fascicularis albumin (ALB) | CSB-MP001561MOV | Mammalian cell | N-terminal 6xHis-Myc-tagged |
| ALB | Recombinant Dog Serum albumin (ALB) | CSB-YP001561DO | Yeast | N-terminal 6xHis-tagged |
| Alb | Recombinant Mouse Albumin (Alb) | CSB-YP001561MO | Yeast | N-terminal 6xHis-tagged |
| ALB | Recombinant Macaca fascicularis albumin (ALB) | CSB-YP001561MOV | Yeast | N-terminal 6xHis-tagged |
| ALB | Recombinant Bovine Serum albumin (ALB) | CSB-YP001561BO | Yeast | C-terminal 6xHis-Myc-tagged |
| ALB | Recombinant Bos taurus Albumin (ALB) | CSB-BP001561BO | Baculovirus | C-terminal 6xHis-tagged |
| Alb | Recombinant Rat Serum albumin (Alb), Biotinylated | CSB-EP001561RA-B | E.coli | N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged |
| ALB | Recombinant Chicken Serum albumin (ALB), partial | CSB-YP001561CH | Yeast | C-terminal 6xHis-tagged |
| ALB | Recombinant Chicken Albumin (ALB), partial | CSB-EP001561CH | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Alb | Recombinant Rat Serum albumin (Alb) | CSB-EP001561RA | E.coli | N-terminal 6xHis-tagged and C-terminal Avi-tagged |
| ALB | Recombinant Dog Serum albumin (ALB), Biotinylated | CSB-EP001561DOg2-B | E.coli | N-terminal 6xHis-Avi-tagged |
| C5AR1 | Recombinant Human C5a anaphylatoxin chemotactic receptor (C5AR1) | CSB-CF003996HUd7 | in vitro E.coli expression system | C-terminal 10xHis-tagged |
● 慢性阻塞性肺疾病研究相關抗體
Phospho-AKT1 (Ser473) Recombinant Monoclonal Antibody
CSB-RA001553A473phHU
Tested Applications: ELISA, WB, IHC, IF, IP
- 重組抗體
| Target Name | Product Name | Code | Species Reactivity | Tested Applications |
|---|---|---|---|---|
| ACVR2B | ACVR2B Recombinant Monoclonal Antibody | CSB-RA260702A0HU | Human | ELISA, IHC |
| ACVR2B | ACVR2B Recombinant Monoclonal Antibody | CSB-RA623829MA1HU | Human | ELISA, IHC, IF |
| AKT1 | Phospho-AKT1 (T450) Recombinant Monoclonal Antibody | CSB-RA001553A450phHU | Human | ELISA, WB |
| AKT1 | Phospho-AKT1 (Ser473) Recombinant Monoclonal Antibody | CSB-RA001553A473phHU | Human | ELISA, WB, IHC, IF, IP |
| AKT1 | AKT1 Recombinant Monoclonal Antibody | CSB-RA917625A0HU | Human, Mouse, Rat | ELISA, WB, IHC, IF |
| ALB | ALB Recombinant Monoclonal Antibody | CSB-RA264109A0HU | Human | ELISA, FC |
| C5AR1 | C5AR1 Recombinant Monoclonal Antibody | CSB-RA003996A0HU | Human | ELISA |
| CCL2 | CCL2 Recombinant Monoclonal Antibody | CSB-RA004783MA1HU | Human | ELISA, IHC |
| CD4 | CD4 Recombinant Monoclonal Antibody | CSB-RA004935A0HU | Human | ELISA, WB, IHC |
| CD8A | CD8A Recombinant Monoclonal Antibody | CSB-RA934881A0HU | Human | ELISA, WB, IHC, IP |
| CRP | CRP Recombinant Monoclonal Antibody | CSB-RA988767A0HU | Human | ELISA, IHC |
| IL10 | IL10 Recombinant Monoclonal Antibody | CSB-RA011580A0HU | Human | ELISA |
| IL10 | IL10 Recombinant Monoclonal Antibody | CSB-RA011580MA1HU | Human | ELISA, IHC |
| IL13RA1 | IL13RA1 Recombinant Monoclonal Antibody | CSB-RA011591MA1HU | Human | ELISA, IHC |
| IL17A | IL17A Recombinant Monoclonal Antibody | CSB-RA624104MA1HU | Human | ELISA |
| IL18 | IL18 Recombinant Monoclonal Antibody | CSB-RA614514MA1HU | Human | ELISA, FC |
| IL1B | IL1B Recombinant Monoclonal Antibody | CSB-RA011614MA1HU | Human | ELISA, IHC, FC |
| IL1R1 | IL1R1 Recombinant Monoclonal Antibody | CSB-RA011621MA1HU | Human | ELISA, FC |
| IL4 | IL4 Recombinant Monoclonal Antibody | CSB-RA240377A0HU | Human | ELISA, IHC |
| IL6 | IL6 Recombinant Monoclonal Antibody | CSB-RA011664MA1HU | Human | ELISA |
- 單克隆抗體
| Target Name | Product Name | Code | Species Reactivity | Tested Applications |
|---|---|---|---|---|
| AKT1 | AKT1 Monoclonal Antibody | CSB-MA011037 | Human,Mouse,Pig,Rat | ELISA, WB |
| ALB | ALB Monoclonal Antibody | CSB-MA076752 | Human | ELISA, WB, IHC |
| CCL2 | CCL2 Monoclonal Antibody | CSB-MA058641A0m | Human | ELISA, IHC |
| CD4 | CD4 Monoclonal Antibody | CSB-MA000228 | Human,Mouse,Rat | ELISA, IHC |
| CD4 | CD4 Monoclonal Antibody,APC Conjugated | CSB-MA043428 | Human | ELISA, IF, FC |
| CD4 | CD4 Monoclonal Antibody,Biotin Conjugated | CSB-MA981329 | Human | ELISA, IF, FC |
| CD4 | CD4 Monoclonal Antibody,FITC Conjugated | CSB-MA124048 | Human | ELISA, IF, FC |
| CD4 | CD4 Monoclonal Antibody,PE Conjugated | CSB-MA260243 | Human | ELISA, IF, FC |
| CD4 | CD4 Monoclonal Antibody,PE-Cy5 Conjugated | CSB-MA570802 | Human | ELISA, IF, FC |
| CD4 | CD4 Monoclonal Antibody,Purified | CSB-MA783233 | Human | ELISA, FC |
| CD4 | CD4 Monoclonal Antibody,PE Conjugated | CSB-MA084552 | Mouse | ELISA, FC |
| CD8A | CD8A Monoclonal Antibody,APC Conjugated | CSB-MA255790 | Human | ELISA, IF, FC |
| CD8A | CD8A Monoclonal Antibody,Biotin Conjugated | CSB-MA955671 | Human | ELISA, IF, FC |
| CD8A | CD8A Monoclonal Antibody,FITC Conjugated | CSB-MA919476 | Human | ELISA, IF, FC |
| CD8A | CD8A Monoclonal Antibody,PE Conjugated | CSB-MA574619 | Human | ELISA, IF, FC |
| CD8A | CD8A Monoclonal Antibody,PE-Cy5 Conjugated | CSB-MA985168 | Human | ELISA, IF, FC |
| CD8A | CD8A Monoclonal Antibody,Purified | CSB-MA927984 | Human | ELISA, FC |
| CRP | CRP Monoclonal Antibody | CSB-MA027411E0m | Human | ELISA, IHC |
| CXCL8 | CXCL8 Monoclonal Antibody | CSB-MA083271A0m | Human | ELISA, IHC |
| IFNG | IFNG Monoclonal Antibody | CSB-MA065241A0m | Human | ELISA, IHC |
| IL1B | IL1B Monoclonal Antibody | CSB-MA065741A0m | Human | ELISA |
| IL1B | IL1B Monoclonal Antibody | CSB-MA010884 | Human | ELISA, WB, IHC, ICC |
| IL6 | IL6 Monoclonal Antibody | CSB-MA067571A0m | Human | ELISA, WB, IHC |
| TNF | TNF Monoclonal Antibody | CSB-MA084771A0m | Bovine | ELISA |
| TNF | TNF Monoclonal Antibody | CSB-MA080271 | Human,Mouse,Rat | ELISA, WB, IHC |
| TNF | TNF Monoclonal Antibody | CSB-MA080272 | Human,Mouse,Rat | ELISA, WB, IHC |
- 多克隆抗體
| Target Name | Product Name | Code | Species Reactivity | Tested Applications |
|---|---|---|---|---|
| ACVR2A | ACVR2A Antibody | CSB-PA001260ESR1HU | Human | ELISA, IHC |
| ACVR2A | ACVR2A Antibody | CSB-PA001260ESR2HU | Human, Mouse | ELISA, WB, IHC |
| ACVR2A | ACVR2A Antibody | CSB-PA070256 | Human, Mouse, Rat | ELISA, WB |
| ACVR2A | ACVR2A Antibody | CSB-PA110386 | Human, Mouse, Rat | ELISA, WB |
| ACVR2A | ACVR2A Antibody | CSB-PA104519 | Human, Mouse, Rat | ELISA, WB, IHC |
| ACVR2A | ACVR2A Antibody | CSB-PA055681 | Human, Mouse, Rat | ELISA, WB, IHC |
| ACVR2B | ACVR2B Antibody | CSB-PA623829ESR1HU | Human | ELISA, IHC |
| ACVR2B | ACVR2B Antibody | CSB-PA292270 | Human, Mouse, Rat | ELISA, IHC |
| ACVR2B | ACVR2B Antibody | CSB-PA206692 | Human, Mouse, Rat | ELISA, WB, IHC |
| AKT1 | AKT1 Antibody | CSB-PA15905A0Rb | Human | ELISA, WB, IHC, IF, IP |
| AKT1 | AKT1 Antibody | CSB-PA000852 | Human, Mouse, Rat | ELISA, WB, IHC, IF |
| AKT1 | Phospho-AKT1 (S124) Antibody | CSB-PA008118 | Human, Mouse, Rat | ELISA, WB, IHC |
| AKT1 | Phospho-AKT1 (T72) Antibody | CSB-PA008120 | Human, Mouse, Rat | ELISA, WB, IHC |
| AKT1 | AKT1 Antibody | CSB-PA008122 | Human, Mouse, Rat | ELISA, IHC |
| AKT1 | AKT1 Antibody | CSB-PA080256 | Human, Mouse, Rat | WB |
| AKT1 | Phospho-AKT1 (S129) Antibody | CSB-PA000645 | Human, Mouse, Rat | ELISA, WB |
| AKT1 | Phospho-AKT1 (T308) Antibody | CSB-PA000657 | Human, Mouse, Rat | ELISA, WB |
| AKT1 | Phospho-AKT1 (S473) Antibody | CSB-PA000732 | Human, Mouse, Rat | ELISA, WB, IHC, IF |
| AKT1 | AKT1 Antibody | CSB-PA000851 | Human, Mouse, Rat, Monkey | ELISA, WB, IHC, IF |
| AKT1 | Phospho-AKT1 (S246) Antibody | CSB-PA000465 | Human, Mouse, Rat | ELISA, WB, IHC, IF |
● 慢性阻塞性肺疾病研究相關ELISA試劑盒
| 靶點 | 產品名稱 | 貨號 | 樣本類型 | 檢測范圍 |
|---|---|---|---|---|
| AKT1 | 人RACα絲氨酸/蘇氨酸蛋白激酶(AKT1)酶聯免疫試劑盒 | CSB-EL001553HU | serum, plasma, cell lysates | 0.312 ng/mL-20 ng/mL |
| ALB | 犬白蛋白(Alb)酶聯免疫試劑盒 | CSB-E15757c | serum, plasma, tissue homogenates | 0.273 μg/mL-35 μg/mL |
| ALB | 小鼠白蛋白酶聯免疫試劑盒 | CSB-E13878m | serum, plasma, tissue homogenates | 0.781 μg/mL-200 μg/mL |
| ALB | 豬白蛋白酶聯免疫試劑盒 | CSB-E16207p | serum, plasma, urine | 0.03 μg/mL-7000 μg/mL |
| ALB | 綿羊白蛋白酶聯免疫試劑盒 | CSB-E15839Sh | serum, plasma, cell culture supernates, urine, tissue homogenates | 5.47 μg/ml-350 μg/ml |
| ALB | 馬白蛋白酶聯免疫試劑盒 | CSB-E16205Hs | serum, plasma | 1.25 μg/mL-80 μg/mL |
| ALB | 牛白蛋白(ALB)酶聯免疫試劑盒 | CSB-E08664b | serum, plasma, tissue homogenates | 0.313 μg/mL-80 μg/mL |
| ALB | 山羊白蛋白(Alb)酶聯免疫試劑盒 | CSB-E15758G | serum, plasma, tissue homogenates | 0.17 μg/mL-350 μg/mL |
| ALB | 兔白蛋白酶聯免疫試劑盒 | CSB-E16204Rb | serum, plasma, urine | 0.273 μg/mL-70 μg/mL |
| ALB | 豚鼠白蛋白(ALB)酶聯免疫試劑盒 | CSB-E15765Gp | serum, plasma, tissue homogenates | 0.156 μg/mL-10 μg/mL |
| CCL2 | 人單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | CSB-E04655h | serum, plasma, urine, saliva, cerebrospinal fluid (CSF), ascitic fluid, cell culture supernates, tis | 6.25 pg/ml-400 pg/ml. |
| CCL2 | 小鼠單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | CSB-E07430m | serum, plasma, tissue homogenates | 78 pg/mL-5000 pg/mL |
| CCL2 | 犬單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | CSB-E15747c | serum, plasma, tissue homogenates | 0.125 ng/mL-8 ng/mL |
| CCL2 | 大鼠單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | CSB-E07429r-IS | serum, plasma, cell culture supernates, tissue homogenates | 3.9 pg/mL-250 pg/mL |
| CCL2 | 豬單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | CSB-E13178p | serum, plasma | 31.25 pg/mL-2000 pg/mL |
| CCL2 | 兔子單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | CSB-E06921Rb | serum, plasma, tissue homogenates | 23.5 pg/mL-1500 pg/mL |
| CCL2 | 大鼠單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | CSB-E07429r | serum, plasma, tissue homogenates | 31.25 pg/mL-2000 pg/mL |
| CCL2 | 牛單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | CSB-E16221B | serum, plasma, tissue homogenates | 78 pg/mL-5000 pg/mL |
| CCL2 | 豚鼠單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | CSB-E13559Gp | serum, plasma, tissue homogenates | 23.5 pg/mL-1500 pg/mL |
| CCL2 | 猴子單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | CSB-E10045Mo | serum, plasma, tissue homogenates | 62.5 pg/mL-4000 pg/mL |
參考文獻
[1] Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs). J Med Chem, 2019.
[2] Identifying Molecular Targets for New Drug Development for Chronic Obstructive Pulmonary Disease: What Does the Future Hold? Semin Respir Crit Care Med, 2015.
[3] New anti-inflammatory targets for chronic obstructive pulmonary disease. Nat Rev Drug Discov, 2013.
[4] New drugs under development for COPD. Minerva Med, 2022.
