每年11月的第三個星期三被定為世界慢性阻塞性肺疾病日（World COPD Day），始于2002年，由全球慢性阻塞性肺疾病倡議組織（GOLD）發(fā)起，旨在提高公眾對慢性阻塞性肺疾病（COPD）的認識，推動早期診斷和治療。
慢性阻塞性肺疾病（COPD），又稱慢性阻塞性肺炎，是一種具有進行性、不可逆特征的氣流受限性疾病。COPD的癥狀包括咳嗽、咳痰、呼吸困難、急性加重、胸悶、氣短等。COPD的主要風險因素包括長期吸煙、職業(yè)性粉塵和化學物質(zhì)暴露等，并與多種炎癥因子有密切關(guān)系。據(jù)統(tǒng)計，COPD已成為世界第三大致死原因，僅次于缺血性心臟病和卒中，不僅嚴重影響患者的生活質(zhì)量，還給患者個人、社會及家庭帶來了沉重的經(jīng)濟負擔。
COPD的病理機制復雜，包括慢性炎癥、氧化應激、蛋白酶與抗蛋白酶失衡、細胞衰老、異常修復機制等 [1][2][3]。炎癥在疾病的發(fā)展中扮演著關(guān)鍵角色，目前的治療方法包括長效支氣管擴張劑和抗炎藥物，但這些方法并不能阻止疾病進展或解決所有問題。正在研發(fā)的新的治療靶點包括炎癥介質(zhì)的調(diào)節(jié)劑、蛋白酶抑制劑、抗氧化劑、激酶抑制劑、PDE4抑制劑、NF-κB抑制劑、senolytics、抗纖維化劑等 [4]。
在治療方面，COPD領(lǐng)域近年來取得了顯著進展，推出了多種新藥物，包括單克隆抗體和小分子化藥。這些藥物通過靶向IL-4Rα、PDE4、PDE3、TSLP等關(guān)鍵分子，為患者提供了更多治療選擇。例如，司普奇拜單抗（Stapokibart）靶向IL-4Rα，已于2024年7月30日在中國獲批。恩塞芬汀（Ensifentrine）作為PDE3和PDE4的雙重抑制劑，于2023年3月10日在美國獲批。特澤魯單抗（Tezepelumab）作為TSLP抑制劑，于2022年1月30日在美國獲批。這些新藥的上市，不僅豐富了COPD的治療手段，也為患者帶來了更多的希望和個性化治療方案。
華美生物長期致力于為科研工作者提供高質(zhì)量的蛋白、抗體、ELISA試劑盒等工具類科研試劑產(chǎn)品，特整理了一系列與慢性阻塞性肺疾病研究相關(guān)的熱門靶點及相關(guān)試劑產(chǎn)品列舉如下，供您選擇。
熱門研究靶點：
● 慢性阻塞性肺疾病研究相關(guān)重組蛋白
C5AR1
CSB-MP003996HU
CSB-MP003996HU
Measured by its binding ability in a functional ELISA. Immobilized human C5AR1 at 10 μg/ml can bind Anti-C5AR1 recombinant antibody (CSB-RA003996A0HU), the EC50 is 1.239-3.760 ng/mL
Measured by its binding ability in a functional ELISA. Immobilized Human IL4 (CSB-MP011659HU) at 2μg/mL can bind biotinylated Human IL4R，the EC50 is 12.68-14.23 ng/mL.
TNFSF13B
CSB-MP897523HU1
CSB-MP897523HU1
Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.
TSLP
CSB-MP5042MOV
CSB-MP5042MOV
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Loaded Cynomolgus TSLP (R127A, R130S) on 96-Flat plate, can bind anti-TSLP antibody (CSB-RA025141MA1HU), with an affinity constant of 4.41 nM as determined in BLI assay (Gator Prime)
| Target | Product Name | Product Code | Source | Tag Info |
|---|---|---|---|---|
| ACVR2B | Recombinant Human Activin receptor type-2B (ACVR2B), partial | CSB-EP623829HU | E.coli | N-terminal 6xHis-B2M-tagged |
| ACVR2B | Recombinant Human Activin receptor type-2B (ACVR2B), partial | CSB-YP623829HU | Yeast | N-terminal 6xHis-tagged |
| ACVR2B | Recombinant Human Activin receptor type-2B (ACVR2B), partial (Active) | CSB-AP005701HU | Mammalian cell | C-terminal 6xHis-Fc-tagged |
| AKT1 | Recombinant Human RAC-alpha serine/threonine-protein kinase (AKT1) | CSB-EP001553HU | E.coli | N-terminal GST-tagged |
| Akt1 | Recombinant Rat RAC-alpha serine/threonine-protein kinase (Akt1) | CSB-EP001553RA | E.coli | N-terminal 10xHis-tagged |
| Alb | Recombinant Mouse Serum albumin (Alb) | CSB-BP001561MO | Baculovirus | C-terminal 9xHis-tagged |
| ALB | Recombinant Dog Serum albumin (ALB) | CSB-EP001561DO | E.coli | N-terminal 6xHis-tagged |
| ALB | Recombinant Macaca fascicularis albumin (ALB) | CSB-EP001561MOV | E.coli | N-terminal 6xHis-SUMO-tagged |
| ALB | Recombinant Macaca fascicularis albumin (ALB) | CSB-MP001561MOV | Mammalian cell | N-terminal 6xHis-Myc-tagged |
| ALB | Recombinant Dog Serum albumin (ALB) | CSB-YP001561DO | Yeast | N-terminal 6xHis-tagged |
| Alb | Recombinant Mouse Albumin (Alb) | CSB-YP001561MO | Yeast | N-terminal 6xHis-tagged |
| ALB | Recombinant Macaca fascicularis albumin (ALB) | CSB-YP001561MOV | Yeast | N-terminal 6xHis-tagged |
| ALB | Recombinant Bovine Serum albumin (ALB) | CSB-YP001561BO | Yeast | C-terminal 6xHis-Myc-tagged |
| ALB | Recombinant Bos taurus Albumin (ALB) | CSB-BP001561BO | Baculovirus | C-terminal 6xHis-tagged |
| Alb | Recombinant Rat Serum albumin (Alb), Biotinylated | CSB-EP001561RA-B | E.coli | N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged |
| ALB | Recombinant Chicken Serum albumin (ALB), partial | CSB-YP001561CH | Yeast | C-terminal 6xHis-tagged |
| ALB | Recombinant Chicken Albumin (ALB), partial | CSB-EP001561CH | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Alb | Recombinant Rat Serum albumin (Alb) | CSB-EP001561RA | E.coli | N-terminal 6xHis-tagged and C-terminal Avi-tagged |
| ALB | Recombinant Dog Serum albumin (ALB), Biotinylated | CSB-EP001561DOg2-B | E.coli | N-terminal 6xHis-Avi-tagged |
| C5AR1 | Recombinant Human C5a anaphylatoxin chemotactic receptor (C5AR1) | CSB-CF003996HUd7 | in vitro E.coli expression system | C-terminal 10xHis-tagged |
● 慢性阻塞性肺疾病研究相關(guān)抗體
Phospho-AKT1 (Ser473) Recombinant Monoclonal Antibody
CSB-RA001553A473phHU
Tested Applications: ELISA, WB, IHC, IF, IP
- 重組抗體
| Target Name | Product Name | Code | Species Reactivity | Tested Applications |
|---|---|---|---|---|
| ACVR2B | ACVR2B Recombinant Monoclonal Antibody | CSB-RA260702A0HU | Human | ELISA, IHC |
| ACVR2B | ACVR2B Recombinant Monoclonal Antibody | CSB-RA623829MA1HU | Human | ELISA, IHC, IF |
| AKT1 | Phospho-AKT1 (T450) Recombinant Monoclonal Antibody | CSB-RA001553A450phHU | Human | ELISA, WB |
| AKT1 | Phospho-AKT1 (Ser473) Recombinant Monoclonal Antibody | CSB-RA001553A473phHU | Human | ELISA, WB, IHC, IF, IP |
| AKT1 | AKT1 Recombinant Monoclonal Antibody | CSB-RA917625A0HU | Human, Mouse, Rat | ELISA, WB, IHC, IF |
| ALB | ALB Recombinant Monoclonal Antibody | CSB-RA264109A0HU | Human | ELISA, FC |
| C5AR1 | C5AR1 Recombinant Monoclonal Antibody | CSB-RA003996A0HU | Human | ELISA |
| CCL2 | CCL2 Recombinant Monoclonal Antibody | CSB-RA004783MA1HU | Human | ELISA, IHC |
| CD4 | CD4 Recombinant Monoclonal Antibody | CSB-RA004935A0HU | Human | ELISA, WB, IHC |
| CD8A | CD8A Recombinant Monoclonal Antibody | CSB-RA934881A0HU | Human | ELISA, WB, IHC, IP |
| CRP | CRP Recombinant Monoclonal Antibody | CSB-RA988767A0HU | Human | ELISA, IHC |
| IL10 | IL10 Recombinant Monoclonal Antibody | CSB-RA011580A0HU | Human | ELISA |
| IL10 | IL10 Recombinant Monoclonal Antibody | CSB-RA011580MA1HU | Human | ELISA, IHC |
| IL13RA1 | IL13RA1 Recombinant Monoclonal Antibody | CSB-RA011591MA1HU | Human | ELISA, IHC |
| IL17A | IL17A Recombinant Monoclonal Antibody | CSB-RA624104MA1HU | Human | ELISA |
| IL18 | IL18 Recombinant Monoclonal Antibody | CSB-RA614514MA1HU | Human | ELISA, FC |
| IL1B | IL1B Recombinant Monoclonal Antibody | CSB-RA011614MA1HU | Human | ELISA, IHC, FC |
| IL1R1 | IL1R1 Recombinant Monoclonal Antibody | CSB-RA011621MA1HU | Human | ELISA, FC |
| IL4 | IL4 Recombinant Monoclonal Antibody | CSB-RA240377A0HU | Human | ELISA, IHC |
| IL6 | IL6 Recombinant Monoclonal Antibody | CSB-RA011664MA1HU | Human | ELISA |
- 單克隆抗體
| Target Name | Product Name | Code | Species Reactivity | Tested Applications |
|---|---|---|---|---|
| AKT1 | AKT1 Monoclonal Antibody | CSB-MA011037 | Human,Mouse,Pig,Rat | ELISA, WB |
| ALB | ALB Monoclonal Antibody | CSB-MA076752 | Human | ELISA, WB, IHC |
| CCL2 | CCL2 Monoclonal Antibody | CSB-MA058641A0m | Human | ELISA, IHC |
| CD4 | CD4 Monoclonal Antibody | CSB-MA000228 | Human,Mouse,Rat | ELISA, IHC |
| CD4 | CD4 Monoclonal Antibody,APC Conjugated | CSB-MA043428 | Human | ELISA, IF, FC |
| CD4 | CD4 Monoclonal Antibody,Biotin Conjugated | CSB-MA981329 | Human | ELISA, IF, FC |
| CD4 | CD4 Monoclonal Antibody,FITC Conjugated | CSB-MA124048 | Human | ELISA, IF, FC |
| CD4 | CD4 Monoclonal Antibody,PE Conjugated | CSB-MA260243 | Human | ELISA, IF, FC |
| CD4 | CD4 Monoclonal Antibody,PE-Cy5 Conjugated | CSB-MA570802 | Human | ELISA, IF, FC |
| CD4 | CD4 Monoclonal Antibody,Purified | CSB-MA783233 | Human | ELISA, FC |
| CD4 | CD4 Monoclonal Antibody,PE Conjugated | CSB-MA084552 | Mouse | ELISA, FC |
| CD8A | CD8A Monoclonal Antibody,APC Conjugated | CSB-MA255790 | Human | ELISA, IF, FC |
| CD8A | CD8A Monoclonal Antibody,Biotin Conjugated | CSB-MA955671 | Human | ELISA, IF, FC |
| CD8A | CD8A Monoclonal Antibody,FITC Conjugated | CSB-MA919476 | Human | ELISA, IF, FC |
| CD8A | CD8A Monoclonal Antibody,PE Conjugated | CSB-MA574619 | Human | ELISA, IF, FC |
| CD8A | CD8A Monoclonal Antibody,PE-Cy5 Conjugated | CSB-MA985168 | Human | ELISA, IF, FC |
| CD8A | CD8A Monoclonal Antibody,Purified | CSB-MA927984 | Human | ELISA, FC |
| CRP | CRP Monoclonal Antibody | CSB-MA027411E0m | Human | ELISA, IHC |
| CXCL8 | CXCL8 Monoclonal Antibody | CSB-MA083271A0m | Human | ELISA, IHC |
| IFNG | IFNG Monoclonal Antibody | CSB-MA065241A0m | Human | ELISA, IHC |
| IL1B | IL1B Monoclonal Antibody | CSB-MA065741A0m | Human | ELISA |
| IL1B | IL1B Monoclonal Antibody | CSB-MA010884 | Human | ELISA, WB, IHC, ICC |
| IL6 | IL6 Monoclonal Antibody | CSB-MA067571A0m | Human | ELISA, WB, IHC |
| TNF | TNF Monoclonal Antibody | CSB-MA084771A0m | Bovine | ELISA |
| TNF | TNF Monoclonal Antibody | CSB-MA080271 | Human,Mouse,Rat | ELISA, WB, IHC |
| TNF | TNF Monoclonal Antibody | CSB-MA080272 | Human,Mouse,Rat | ELISA, WB, IHC |
- 多克隆抗體
| Target Name | Product Name | Code | Species Reactivity | Tested Applications |
|---|---|---|---|---|
| ACVR2A | ACVR2A Antibody | CSB-PA001260ESR1HU | Human | ELISA, IHC |
| ACVR2A | ACVR2A Antibody | CSB-PA001260ESR2HU | Human, Mouse | ELISA, WB, IHC |
| ACVR2A | ACVR2A Antibody | CSB-PA070256 | Human, Mouse, Rat | ELISA, WB |
| ACVR2A | ACVR2A Antibody | CSB-PA110386 | Human, Mouse, Rat | ELISA, WB |
| ACVR2A | ACVR2A Antibody | CSB-PA104519 | Human, Mouse, Rat | ELISA, WB, IHC |
| ACVR2A | ACVR2A Antibody | CSB-PA055681 | Human, Mouse, Rat | ELISA, WB, IHC |
| ACVR2B | ACVR2B Antibody | CSB-PA623829ESR1HU | Human | ELISA, IHC |
| ACVR2B | ACVR2B Antibody | CSB-PA292270 | Human, Mouse, Rat | ELISA, IHC |
| ACVR2B | ACVR2B Antibody | CSB-PA206692 | Human, Mouse, Rat | ELISA, WB, IHC |
| AKT1 | AKT1 Antibody | CSB-PA15905A0Rb | Human | ELISA, WB, IHC, IF, IP |
| AKT1 | AKT1 Antibody | CSB-PA000852 | Human, Mouse, Rat | ELISA, WB, IHC, IF |
| AKT1 | Phospho-AKT1 (S124) Antibody | CSB-PA008118 | Human, Mouse, Rat | ELISA, WB, IHC |
| AKT1 | Phospho-AKT1 (T72) Antibody | CSB-PA008120 | Human, Mouse, Rat | ELISA, WB, IHC |
| AKT1 | AKT1 Antibody | CSB-PA008122 | Human, Mouse, Rat | ELISA, IHC |
| AKT1 | AKT1 Antibody | CSB-PA080256 | Human, Mouse, Rat | WB |
| AKT1 | Phospho-AKT1 (S129) Antibody | CSB-PA000645 | Human, Mouse, Rat | ELISA, WB |
| AKT1 | Phospho-AKT1 (T308) Antibody | CSB-PA000657 | Human, Mouse, Rat | ELISA, WB |
| AKT1 | Phospho-AKT1 (S473) Antibody | CSB-PA000732 | Human, Mouse, Rat | ELISA, WB, IHC, IF |
| AKT1 | AKT1 Antibody | CSB-PA000851 | Human, Mouse, Rat, Monkey | ELISA, WB, IHC, IF |
| AKT1 | Phospho-AKT1 (S246) Antibody | CSB-PA000465 | Human, Mouse, Rat | ELISA, WB, IHC, IF |
● 慢性阻塞性肺疾病研究相關(guān)ELISA試劑盒
| 靶點 | 產(chǎn)品名稱 | 貨號 | 樣本類型 | 檢測范圍 |
|---|---|---|---|---|
| AKT1 | 人RACα絲氨酸/蘇氨酸蛋白激酶(AKT1)酶聯(lián)免疫試劑盒 | CSB-EL001553HU | serum, plasma, cell lysates | 0.312 ng/mL-20 ng/mL |
| ALB | 犬白蛋白(Alb)酶聯(lián)免疫試劑盒 | CSB-E15757c | serum, plasma, tissue homogenates | 0.273 μg/mL-35 μg/mL |
| ALB | 小鼠白蛋白酶聯(lián)免疫試劑盒 | CSB-E13878m | serum, plasma, tissue homogenates | 0.781 μg/mL-200 μg/mL |
| ALB | 豬白蛋白酶聯(lián)免疫試劑盒 | CSB-E16207p | serum, plasma, urine | 0.03 μg/mL-7000 μg/mL |
| ALB | 綿羊白蛋白酶聯(lián)免疫試劑盒 | CSB-E15839Sh | serum, plasma, cell culture supernates, urine, tissue homogenates | 5.47 μg/ml-350 μg/ml |
| ALB | 馬白蛋白酶聯(lián)免疫試劑盒 | CSB-E16205Hs | serum, plasma | 1.25 μg/mL-80 μg/mL |
| ALB | 牛白蛋白(ALB)酶聯(lián)免疫試劑盒 | CSB-E08664b | serum, plasma, tissue homogenates | 0.313 μg/mL-80 μg/mL |
| ALB | 山羊白蛋白(Alb)酶聯(lián)免疫試劑盒 | CSB-E15758G | serum, plasma, tissue homogenates | 0.17 μg/mL-350 μg/mL |
| ALB | 兔白蛋白酶聯(lián)免疫試劑盒 | CSB-E16204Rb | serum, plasma, urine | 0.273 μg/mL-70 μg/mL |
| ALB | 豚鼠白蛋白(ALB)酶聯(lián)免疫試劑盒 | CSB-E15765Gp | serum, plasma, tissue homogenates | 0.156 μg/mL-10 μg/mL |
| CCL2 | 人單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒 | CSB-E04655h | serum, plasma, urine, saliva, cerebrospinal fluid (CSF), ascitic fluid, cell culture supernates, tis | 6.25 pg/ml-400 pg/ml. |
| CCL2 | 小鼠單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒 | CSB-E07430m | serum, plasma, tissue homogenates | 78 pg/mL-5000 pg/mL |
| CCL2 | 犬單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒 | CSB-E15747c | serum, plasma, tissue homogenates | 0.125 ng/mL-8 ng/mL |
| CCL2 | 大鼠單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒 | CSB-E07429r-IS | serum, plasma, cell culture supernates, tissue homogenates | 3.9 pg/mL-250 pg/mL |
| CCL2 | 豬單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒 | CSB-E13178p | serum, plasma | 31.25 pg/mL-2000 pg/mL |
| CCL2 | 兔子單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒 | CSB-E06921Rb | serum, plasma, tissue homogenates | 23.5 pg/mL-1500 pg/mL |
| CCL2 | 大鼠單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒 | CSB-E07429r | serum, plasma, tissue homogenates | 31.25 pg/mL-2000 pg/mL |
| CCL2 | 牛單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒 | CSB-E16221B | serum, plasma, tissue homogenates | 78 pg/mL-5000 pg/mL |
| CCL2 | 豚鼠單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒 | CSB-E13559Gp | serum, plasma, tissue homogenates | 23.5 pg/mL-1500 pg/mL |
| CCL2 | 猴子單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒 | CSB-E10045Mo | serum, plasma, tissue homogenates | 62.5 pg/mL-4000 pg/mL |
參考文獻
[1] Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs). J Med Chem, 2019.
[2] Identifying Molecular Targets for New Drug Development for Chronic Obstructive Pulmonary Disease: What Does the Future Hold? Semin Respir Crit Care Med, 2015.
[3] New anti-inflammatory targets for chronic obstructive pulmonary disease. Nat Rev Drug Discov, 2013.
[4] New drugs under development for COPD. Minerva Med, 2022.
