CCL2，全稱為趨化因子C-C motif ligand 2，也稱為單核細(xì)胞趨化蛋白1（MCP-1）。它是一種細(xì)胞因子，參與了許多生理和病理過程，如炎癥、腫瘤、自身免疫性疾病等。CCL2主要由單核細(xì)胞、巨噬細(xì)胞和內(nèi)皮細(xì)胞分泌，在炎癥和組織損傷時(shí)被激活。CCL2可引導(dǎo)單核細(xì)胞、記憶性T細(xì)胞和樹突狀細(xì)胞等進(jìn)入炎癥和損傷組織，促進(jìn)炎癥反應(yīng)和組織修復(fù)。CCL2也參與了腫瘤的發(fā)生和發(fā)展，可以引起腫瘤相關(guān)的炎癥反應(yīng)，增加腫瘤細(xì)胞的浸潤(rùn)和轉(zhuǎn)移。

Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. May play a significant role in monocyte trafficking into the reperfused myocardium.

1. Analysis of ROC suggests the use of serum levels of MCP-1 and IL-7 as predictors of the occurrence of complications with an AUC of 0.906 and 0.896 respectively and linear combinations of MCP-1, KC-Like, IL-7 and GM-CSF with values up to AUC = 0.983 PMID: 29304171
2. data suggest that CCL2 acts as a PMNs chemotactic factor as well as CXCL8, and both CCL2 and CXCL8 facilitate the infiltration of PMNs into the joints of idiopathic polyarthritis PMID: 27863550
3. The study findings suggest that both CCL2 and CXCL8 are involved in the pathogenesis of canine idiopathic pulmonary fibrosis. PMID: 26231926
4. CCL2 concentrations might be related to the breed predisposition of the West Highland white terrier for canine idiopathic pulmonary fibrosis. PMID: 26267090
5. MCP-1 might be helpful as a screening blood test marker for detection of neoplasia and inflammation in dogs. PMID: 22986270
6. Adipose tissue-derived mesenchymal stem cells expressed the mRNA of transforming growth factor beta (TGF-beta), IL-6, IL-8, CCL2, CCL5, VEGF,HGF, tissue inhibitor metalloproteinase-1/2, and cyclooxygenase-2 but not that of IL-10. PMID: 18717642

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Secreted.

Intercrine beta (chemokine CC) family

Endothelium of small veins and intrafascicular veins, and infiltrating leukocytes.

KEGG: cfa:403981

STRING: 9615.ENSCAFP00000027107

UniGene: Cfa.3851