MMP12
MMP12，即基質(zhì)金屬肽酶12，別名Macrophageelastase。它是一種主要由成熟組織巨噬細(xì)胞表達(dá)的酶，屬于基質(zhì)金屬蛋白酶家族成員之一。MMP12的作用機制涉及降解多種細(xì)胞外基質(zhì)成分，如Ⅳ型膠原、硫酸軟骨素、層粘連蛋白及纖溶酶原等。MMP12參與腫瘤細(xì)胞的侵襲和轉(zhuǎn)移，促進(jìn)多種腫瘤如鼻咽癌、結(jié)直腸癌等的侵襲和轉(zhuǎn)移，同時也參與許多肺部疾病的病理過程，如慢性阻塞性肺疾病、過敏性哮喘、肺氣腫、肺纖維化和肺部感染等。MMP12還與動脈粥樣硬化斑塊的進(jìn)展和不穩(wěn)定性相關(guān)，并可能參與動脈粥樣硬化性腦梗死及冠心病的病理過程。MMP12在病理學(xué)研究和疾病治療中具有重要的生物學(xué)意義和潛在的治療應(yīng)用價值。
熱銷產(chǎn)品
Recombinant Human Macrophage metalloelastase (MMP12) (CSB-EP014659HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP014659HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MMP12.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP014659HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MMP12.
MMP12 Recombinant Monoclonal Antibody (CSB-RA595609A0HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: 293T whole cell lysate, MCF-7 whole cell lysate, THP-1 whole cell lysate
All lanes: MMP12 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 55 kDa
Observed band size: 54, 45 kDa
IHC image of CSB-RA595609A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
Human Matrix Metalloproteinase 12(MMP-12) ELISA Kit (CSB-E13208h)
驗證數(shù)據(jù)
貨號：CSB-E13208h
規(guī)格：96T/48T
靈敏度：0.156 ng/mL
檢測范圍：0.625 ng/mL-40 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
MMP12 Antibodies
MMP12 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA12379A0Rb | MMP12 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA000049 | Cleaved-MMP12 (G106) Antibody | Human | WB, ELISA |
| CSB-PA004869 | MMP12 Antibody | Human,Mouse | WB, ELISA |
| CSB-PA010210 | MMP12 Antibody | Human | WB, IHC, ELISA |
| CSB-PA984456 | MMP12 Antibody | Human | ELISA,IHC |
| CSB-RA595609A0HU | MMP12 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
MMP12 Proteins
MMP12 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP014659HU CSB-BP014659HU CSB-MP014659HU CSB-EP014659HU-B |
Recombinant Human Macrophage metalloelastase (MMP12) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP014659HU | Recombinant Human Macrophage metalloelastase (MMP12) | E.coli |
MMP12 ELISA Kit
MMP12 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13208h | Human Matrix Metalloproteinase 12(MMP-12) ELISA Kit | serum, plasma, tissue homogenates | 0.156 ng/mL |
