CD37 (ivicentamab Biosimilar) Recombinant Monoclonal Antibody
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貨號：CSB-RA004928MB1HU
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規格：
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：CD 37 antibody; CD37 antibody; CD37 antigen antibody; CD37 molecule antibody; CD37_HUMAN antibody; Cell differentiation antigen 37 antibody; GP52 40 antibody; Leukocyte antigen CD37 antibody; Leukocyte surface antigen CD37 antibody; MGC120234 antibody; Tetraspanin 26 antibody; Tetraspanin-26 antibody; Tetraspanin26 antibody; TSPAN 26 antibody; Tspan-26 antibody; TSPAN26 antibody
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反應種屬：Human
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免疫原：Recombinant Human CD37 protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.120 -
產品提供形式：Liquid
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應用說明：Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：In stock
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用途：It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
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靶點詳情
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基因功能參考文獻：
- CD37 is a critical determinant of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone outcome in diffuse large B-cell lymphoma. PMID: 27760757
- Data indicate that cell differentiation antigen 37 (CD37) is well expressed and a potential drug target in acute myeloid leukemia (AML). PMID: 25934707
- The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model. PMID: 24445867
- Data indicate that enhanced antibody-dependent cell cytotoxicity (ADCC) is observed against chronic lymphocytic leukemia cells and is sustained at concentrations of SMIP-016(GV) as low at 5E(-6) microg/mL on cells expressing minimal CD37 antigen. PMID: 23883821
- Identify two tyrosine residues in tetraspanin CD37 directly mediating transduction of survival and apoptotic signals. PMID: 22624718
- In the absence of both CD37 and Tssc6, immune function is further altered when compared with CD37- or Tssc6-deficient transgenic mice, demonstrating a complementary role for these two molecules in cellular immunity. PMID: 20709950
- CD37 cross-linking on human T cells transduces signals that lead to complete inhibition of CD3-induced T cell proliferation. PMID: 14978098
- CD37 is important for dectin-1 stabilization in APC membranes and controls dectin-1-mediated IL-6 production. PMID: 17182550
- provide strong justification for CD37 as a therapeutic target and introduce small modular immunopharmaceuticals as a novel class of targeted therapies for B-cell malignancies PMID: 17440052
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亞細胞定位：Membrane; Multi-pass membrane protein.
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蛋白家族：Tetraspanin (TM4SF) family
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組織特異性：B-lymphocytes.
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