CD37 Recombinant Monoclonal Antibody

說明書

中文名稱：

CD37重組抗體
貨號：

CSB-RA004928MA1HU
規格：

￥1320
圖片：
IHC image of CSB-RA004928MA1HU diluted at 1:200 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
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產品詳情
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靶點詳情

產品詳情

產品描述：

CSB-RA004928MA1HU CD37重組單克隆抗體是針對人源CD37抗原設計的高特異性科研工具。CD37作為四次跨膜蛋白家族成員，在B淋巴細胞表面特異性表達，參與調控細胞黏附、遷移及信號轉導，其異常表達與B細胞淋巴瘤等疾病密切相關。本抗體經ELISA及免疫組化（IHC）雙重平臺驗證，在IHC應用中可清晰顯示石蠟包埋組織中B淋巴細胞的膜定位特征，推薦使用稀釋度為1:50-1:200，能有效區分目標蛋白的組織分布差異。ELISA檢測體系顯示其具備出色的線性反應范圍，適用于體外樣本的定量分析。該產品可為B細胞發育分化研究、淋巴瘤微環境分析、免疫細胞表面標記物檢測等實驗提供可靠支持，尤其在探究B細胞相關疾病的分子機制、篩選潛在治療靶點及開發體外檢測方法等領域具有重要應用價值。通過嚴格的抗原親和純化工藝，確保批次間穩定性，適用于需要高重復性的長期研究項目。
Uniprot No.：

P11049
基因名：

CD37
別名：

CD37 Recombinant Monoclonal Antibody
反應種屬：

Human
免疫原：

Recombinant Human CD37 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

hIgG1
純化方式：

Affinity-chromatography
克隆號：

9H6
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

基因功能參考文獻：
1. CD37 is a critical determinant of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone outcome in diffuse large B-cell lymphoma. PMID: 27760757
2. Data indicate that cell differentiation antigen 37 (CD37) is well expressed and a potential drug target in acute myeloid leukemia (AML). PMID: 25934707
3. The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model. PMID: 24445867
4. Data indicate that enhanced antibody-dependent cell cytotoxicity (ADCC) is observed against chronic lymphocytic leukemia cells and is sustained at concentrations of SMIP-016(GV) as low at 5E(-6) microg/mL on cells expressing minimal CD37 antigen. PMID: 23883821
5. Identify two tyrosine residues in tetraspanin CD37 directly mediating transduction of survival and apoptotic signals. PMID: 22624718
6. In the absence of both CD37 and Tssc6, immune function is further altered when compared with CD37- or Tssc6-deficient transgenic mice, demonstrating a complementary role for these two molecules in cellular immunity. PMID: 20709950
7. CD37 cross-linking on human T cells transduces signals that lead to complete inhibition of CD3-induced T cell proliferation. PMID: 14978098
8. CD37 is important for dectin-1 stabilization in APC membranes and controls dectin-1-mediated IL-6 production. PMID: 17182550
9. provide strong justification for CD37 as a therapeutic target and introduce small modular immunopharmaceuticals as a novel class of targeted therapies for B-cell malignancies PMID: 17440052
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亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Tetraspanin (TM4SF) family
組織特異性：

B-lymphocytes.
數據庫鏈接：

HGNC: 1666

OMIM: 151523

KEGG: hsa:951

STRING: 9606.ENSP00000325708

UniGene: Hs.166556

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