ABCB1
ABCB1，即三磷酸腺苷結(jié)合盒轉(zhuǎn)運(yùn)蛋白B1，別名MDR1、CD243。它是由人類(lèi)ABCB1基因編碼的一種跨膜蛋白，主要在血腦屏障、肝臟、腸道、腎臟等器官的細(xì)胞中表達(dá)。ABCB1的作用機(jī)制是通過(guò)ATP水解提供能量，將藥物和其他底物逆濃度梯度從細(xì)胞內(nèi)部運(yùn)輸?shù)郊?xì)胞外，從而減少細(xì)胞內(nèi)藥物濃度，導(dǎo)致多藥耐藥現(xiàn)象。ABCB1參與細(xì)胞解毒、維持細(xì)胞內(nèi)穩(wěn)態(tài)，同時(shí)也影響藥物的吸收、分布、代謝和排泄，是藥物耐藥性的關(guān)鍵因素之一。ABCB1的異常表達(dá)與多種疾病的治療抵抗性相關(guān)，如腫瘤的多藥耐藥性。
熱銷(xiāo)產(chǎn)品
Recombinant Human ATP-dependent translocase ABCB1 (ABCB1), partial (CSB-EP001046HU2)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ABCB1 Recombinant Monoclonal Antibody (CSB-RA983422A0HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA983422A0HU diluted at 1:100 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
Immunofluorescence staining of HepG2 cell with CSB-RA983422A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 583-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
ABCB1 Antibodies
ABCB1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA11737A0Rb | ABCB1 Antibody | Human | ELISA, IHC |
| CSB-PA030050 | ABCB1 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA598314 | ABCB1 Antibody | Human | ELISA,IHC |
| CSB-RA983422A0HU | ABCB1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF |
ABCB1 Proteins
ABCB1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP001046RA CSB-EP001046RA CSB-BP001046RA CSB-MP001046RA CSB-EP001046RA-B |
Recombinant Rat Multidrug resistance protein 1 (Abcb1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ABCB1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP001046HU CSB-EP001046HU CSB-BP001046HU CSB-MP001046HU CSB-EP001046HU-B |
Recombinant Human ATP-dependent translocase ABCB1 (ABCB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP001046HU1 | Recombinant Human ATP-dependent translocase ABCB1 (ABCB1), partial | E.coli |
| CSB-EP001046HU2 | Recombinant Human ATP-dependent translocase ABCB1 (ABCB1), partial | E.coli |
ABCB1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP001046DXU CSB-EP001046DXU CSB-BP001046DXU CSB-MP001046DXU CSB-EP001046DXU-B |
Recombinant Cricetulus griseus Multidrug resistance protein 1 (ABCB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ABCB1 Proteins for Dictyostelium discoideum (Slime mold)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP684501DKK CSB-EP684501DKK CSB-BP684501DKK CSB-MP684501DKK CSB-EP684501DKK-B |
Recombinant Dictyostelium discoideum ABC transporter B family member 1 (abcB1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ABCB1 ELISA Kit
ABCB1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-E11709h | Human permeability glycoprotein,P-gp/ABCB1 ELISA Kit | serum, plasma, ascitic fluid, tissue homogenates | 0.78 ng/mL |
