據(jù)估計(jì)，慢性腎臟病（CKD）影響著全球8.5億多人，2019年導(dǎo)致310多萬(wàn)人死亡 [1]。目前，腎臟病是導(dǎo)致死亡的第8大原因 [2]，如果不加以解決，預(yù)計(jì)到2040年，它將成為導(dǎo)致壽命損失的第5大原因 [3]。
鑒于當(dāng)前全球慢性腎臟病發(fā)病率不斷上升，而公眾對(duì)該病的防治知識(shí)還有待提高，經(jīng)國(guó)際腎臟病學(xué)會(huì)與國(guó)際腎臟基金聯(lián)盟聯(lián)合提議，決定從2006年起將每年3月份的第二個(gè)星期四確定為世界腎臟日，目的在于提高人們對(duì)慢性腎臟病以及相關(guān)的心血管疾病和死亡率的認(rèn)識(shí)，并重視在慢性腎臟病的早期的檢測(cè)和預(yù)防方面全球的迫切需求。
2024年3月14日，是第17個(gè)世界腎臟日，主題為“關(guān)注腎臟護(hù)理中的差距：將我們的知識(shí)轉(zhuǎn)化為我們的行動(dòng)”[4]。從歷史上看，新療法從臨床證據(jù)轉(zhuǎn)化為日常實(shí)踐平均需要17年時(shí)間。鑒于目前已有的預(yù)防或延緩腎病發(fā)病和進(jìn)展的高效治療方法，這個(gè)時(shí)間太長(zhǎng)了。對(duì)于預(yù)防和管理腎臟疾病的常見(jiàn)風(fēng)險(xiǎn)因素，如高血壓和糖尿病，已有明確的指導(dǎo)原則。對(duì)于高血壓和糖尿病等腎臟疾病常見(jiàn)風(fēng)險(xiǎn)因素的預(yù)防和管理，已經(jīng)有了明確的指導(dǎo)方針，但全世界只有一小部分患有這些疾病的人得到了治療和診斷，而絕大多數(shù)腎病患者都不知道自己的病情，因?yàn)槟I病在早期往往是無(wú)聲無(wú)息的。因此，腎病的早期檢測(cè)和防治至關(guān)重要，而對(duì)于其致病機(jī)制的研究，相關(guān)信號(hào)通路研究、標(biāo)志物的開(kāi)發(fā)，也是科學(xué)家們一直在研究和探索的方向。
華美生物自成立至今，已有17年，長(zhǎng)期致力于為科研工作者提供高質(zhì)量的蛋白、抗體、ELISA試劑盒等工具類科研試劑產(chǎn)品。特篩選了針對(duì)腎臟病研究熱度最高的25個(gè)靶點(diǎn)，并整理了相關(guān)的試劑產(chǎn)品列舉如下，供您選擇：
華美生物蛋白產(chǎn)品：
| 產(chǎn)品名稱 | 貨號(hào) | 靶點(diǎn) | 來(lái)源 | 蛋白標(biāo)簽 |
|---|---|---|---|---|
| Recombinant Enterobacteria phage T4 DNA alpha-glucosyltransferase (agt) | CSB-EP356278EDZ | agt | E.coli | N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged |
| Recombinant Human RAC-alpha serine/threonine-protein kinase (AKT1) | CSB-EP001553HU | AKT1 | E.coli | N-terminal GST-tagged |
| Recombinant Rat RAC-alpha serine/threonine-protein kinase (Akt1) | CSB-EP001553RA | Akt1 | E.coli | N-terminal 10xHis-tagged |
| Recombinant Mouse Serum albumin (Alb) | CSB-BP001561MO | Alb | Baculovirus | C-terminal 9xHis-tagged |
| Recombinant Macaca fascicularis albumin (ALB) | CSB-MP001561MOV | ALB | Mammalian cell | N-terminal 6xHis-Myc-tagged |
| Recombinant Dog Serum albumin (ALB) | CSB-YP001561DO | ALB | Yeast | N-terminal 6xHis-tagged |
| Recombinant Mouse Albumin (Alb) | CSB-YP001561MO | Alb | Yeast | N-terminal 6xHis-tagged |
| Recombinant Macaca fascicularis albumin (ALB) | CSB-YP001561MOV | ALB | Yeast | N-terminal 6xHis-tagged |
| Recombinant Bovine Serum albumin (ALB) | CSB-YP001561BO | ALB | Yeast | C-terminal 6xHis-Myc-tagged |
| Recombinant Chicken Serum albumin (ALB), partial | CSB-YP001561CH | ALB | Yeast | C-terminal 6xHis-tagged |
| Recombinant Chicken Albumin (ALB), partial | CSB-EP001561CH | ALB | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Recombinant Rat Serum albumin (Alb) | CSB-EP001561RA | Alb | E.coli | N-terminal 6xHis-tagged and C-terminal Avi-tagged |
| Recombinant Human C-C motif chemokine 2 (CCL2) | CSB-EP004783HUb1 | CCL2 | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Recombinant Mouse C-C motif chemokine 2 (Ccl2), partial | CSB-EP004783MO | CCL2 | E.coli | N-terminal 6xHis-tagged |
| Recombinant Human CD59 glycoprotein (CD59) | CSB-EP004947HU | CD59 | E.coli | N-terminal GST-tagged |
| Recombinant Human CD59 glycoprotein (CD59) | CSB-YP004947HU | CD59 | Yeast | N-terminal 6xHis-tagged |
| Recombinant Mouse Cystatin-C (Cst3) | CSB-EP006091MO | Cst3 | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Recombinant Human Epidermal growth factor receptor (EGFR), partial | CSB-EP007479HU3 | EGFR | E.coli | N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged |
| Recombinant Human Epidermal growth factor receptor (EGFR), partial | CSB-EP007479HU | EGFR | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
| Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) | CSB-MP007479HU | EGFR | Mammalian cell | N-terminal 10xHis-tagged and C-terminal Myc-tagged |
華美生物抗體產(chǎn)品：
● 重組抗體：
| 產(chǎn)品名稱 | 貨號(hào) | 靶點(diǎn) | 反應(yīng)種屬 | 應(yīng)用范圍 |
|---|---|---|---|---|
| ACE Recombinant Monoclonal Antibody | CSB-RA268157A0HU | ACE | Human | ELISA, IHC |
| AGT Recombinant Monoclonal Antibody | CSB-RA263831A0HU | AGT | Human | ELISA, IHC |
| Phospho-AKT1 (T450) Recombinant Monoclonal Antibody | CSB-RA001553A450phHU | AKT1 | Human | ELISA, WB |
| Phospho-AKT1 (Ser473) Recombinant Monoclonal Antibody | CSB-RA001553A473phHU | AKT1 | Human | ELISA, WB, IHC, IF, IP |
| AKT1 Recombinant Monoclonal Antibody | CSB-RA917625A0HU | AKT1 | Human, Mouse, Rat | ELISA, WB, IHC, IF |
| ALB Recombinant Monoclonal Antibody | CSB-RA264109A0HU | ALB | Human | ELISA, FC |
| CD4 Recombinant Monoclonal Antibody | CSB-RA004935A0HU | CD4 | Human | ELISA, WB, IHC |
| CD59 Recombinant Monoclonal Antibody | CSB-RA046065A0HU | CD59 | Human | ELISA, FC |
| CRP Recombinant Monoclonal Antibody | CSB-RA988767A0HU | CRP | Human | ELISA, IHC |
| Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | CSB-RA007479A1092phHU | EGFR | Human | ELISA, WB |
| Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | CSB-RA007479A1068phHU | EGFR | Human | ELISA, WB |
| EGFR Recombinant Monoclonal Antibody | CSB-RA159341A0HU | EGFR | Human | ELISA, WB, IHC, IF, FC |
| EGFR Recombinant Monoclonal Antibody | CSB-RA794061A0HU | EGFR | Human | ELISA, WB, IHC |
| EGFR Recombinant Monoclonal Antibody | CSB-RA159341MA1HU | EGFR | Human | ELISA, IHC, FC |
| IL6 Recombinant Monoclonal Antibody | CSB-RA011664MA1HU | IL6 | Human | ELISA |
| INS Recombinant Monoclonal Antibody | CSB-RA584163A0HU | INS | Human | ELISA, IHC |
| Phospho-MTOR (S2481) Recombinant Monoclonal Antibody | CSB-RA008968A2481phHU | MTOR | Human | ELISA, WB, IF |
| Phospho-MTOR (S2448) Recombinant Monoclonal Antibody | CSB-RA008968A2448phHU | MTOR | Human | ELISA, WB, IHC, IF |
● 單克隆抗體：
| 產(chǎn)品名稱 | 貨號(hào) | 靶點(diǎn) | 反應(yīng)種屬 | 應(yīng)用范圍 |
|---|---|---|---|---|
| ACE Monoclonal Antibody | CSB-MA904961 | ACE | Human,Mouse,Rat | ELISA, WB |
| AKT1 Monoclonal Antibody | CSB-MA011037 | AKT1 | Human,Mouse,Pig,Rat | ELISA, WB |
| ALB Monoclonal Antibody | CSB-MA076752 | ALB | Human | ELISA, WB, IHC |
| CCL2 Monoclonal Antibody | CSB-MA058641A0m | CCL2 | Human | ELISA, IHC |
| CD4 Monoclonal Antibody | CSB-MA000228 | CD4 | Human,Mouse,Rat | ELISA, IHC |
| CD4 Monoclonal Antibody,APC Conjugated | CSB-MA043428 | CD4 | Human | ELISA, IF, FC |
| CD4 Monoclonal Antibody,Biotin Conjugated | CSB-MA981329 | CD4 | Human | ELISA, IF, FC |
| CD4 Monoclonal Antibody,FITC Conjugated | CSB-MA124048 | CD4 | Human | ELISA, IF, FC |
| CD4 Monoclonal Antibody,PE Conjugated | CSB-MA260243 | CD4 | Human | ELISA, IF, FC |
| CD4 Monoclonal Antibody,PE-Cy5 Conjugated | CSB-MA570802 | CD4 | Human | ELISA, IF, FC |
| CD4 Monoclonal Antibody,Purified | CSB-MA783233 | CD4 | Human | ELISA, FC |
| CD4 Monoclonal Antibody,PE Conjugated | CSB-MA084552 | CD4 | Mouse | ELISA, FC |
| CD59 Monoclonal Antibody | CSB-MA0049471A0m | CD59 | Human | ELISA, WB, IHC |
| CRP Monoclonal Antibody | CSB-MA027411E0m | CRP | Human | ELISA, IHC |
| CST3 Monoclonal Antibody | CSB-MA061901A0m | CST3 | Human | ELISA, IHC |
| EGFR Monoclonal Antibody | CSB-MA000199 | EGFR | Human | ELISA, WB, IHC, IF |
| EGFR Monoclonal Antibody | CSB-MA000293 | EGFR | Human | ELISA, WB |
| IL6 Monoclonal Antibody | CSB-MA067571A0m | IL6 | Human | ELISA, WB, IHC |
| LCN2 Monoclonal Antibody | CSB-MA068302A0m | LCN2 | Human,Mouse | ELISA, WB, IHC |
| LCN2 Monoclonal Antibody | CSB-MA068341A0m | LCN2 | Human,Mouse | ELISA, WB |
| PTH Monoclonal Antibody | CSB-MA0189871A0m | PTH | Human | ELISA |
| TNF Monoclonal Antibody | CSB-MA084771A0m | TNF | Bovine | ELISA |
| TNF Monoclonal Antibody | CSB-MA080271 | TNF | Human,Mouse,Rat | ELISA, WB, IHC |
| TNF Monoclonal Antibody | CSB-MA080272 | TNF | Human,Mouse,Rat | ELISA, WB, IHC |
● 多克隆抗體：
| 產(chǎn)品名稱 | 貨號(hào) | 靶點(diǎn) | 反應(yīng)種屬 | 應(yīng)用范圍 |
|---|---|---|---|---|
| Ace Antibody | CSB-PA001149LA01RA | Ace | Rat | ELISA, IHC |
| Ace Antibody, HRP conjugated | CSB-PA001149LB01RA | Ace | Rat | ELISA |
| Ace Antibody, FITC conjugated | CSB-PA001149LC01RA | Ace | Rat | |
| Ace Antibody, Biotin conjugated | CSB-PA001149LD01RA | Ace | Rat | ELISA |
| ACE Antibody | CSB-PA007661 | ACE | Human, Mouse, Rat | ELISA, WB, IHC |
| ACE Antibody | CSB-PA794185 | ACE | Human, Mouse | ELISA, IHC |
| ACE Antibody | CSB-PA152113 | ACE | Human, Mouse, Rat | ELISA, WB |
| ACE Antibody | CSB-PA172536 | ACE | Human, Mouse, Rat | ELISA, WB |
| ACE Antibody | CSB-PA271234 | ACE | Human, Mouse, Rat | ELISA, WB, IHC |
| ACE Antibody | CSB-PA575032 | ACE | Human, Mouse, Rat | ELISA, WB, IHC |
| AGT Antibody | CSB-PA10079A0Rb | AGT | Human | ELISA, WB, IHC, IF |
| AGT Antibody, HRP conjugated | CSB-PA10079B0Rb | AGT | Human | ELISA |
| AGT Antibody, FITC conjugated | CSB-PA10079C0Rb | AGT | Human | |
| AGT Antibody, Biotin conjugated | CSB-PA10079D0Rb | AGT | Human | ELISA |
| AGT Antibody | CSB-PA001463ESR1HU | AGT | Human | ELISA, IHC, IF |
| AGT Antibody | CSB-PA001463ESR2HU | AGT | Human, Mouse | ELISA, WB, IHC, IF |
| AGT Antibody | CSB-PA001463EA01HU | AGT | Human, Rat | ELISA, WB, IHC |
| AGT Antibody, HRP conjugated | CSB-PA001463EB01HU | AGT | Human | ELISA |
| AGT Antibody, FITC conjugated | CSB-PA001463EC01HU | AGT | Human | |
| AGT Antibody, Biotin conjugated | CSB-PA001463ED01HU | AGT | Human | ELISA |
華美生物ELISA試劑盒產(chǎn)品：
| 產(chǎn)品名稱 | 貨號(hào) | 靶點(diǎn) | 檢測(cè)范圍 | 靈敏度 |
|---|---|---|---|---|
| 大鼠血管緊張素轉(zhuǎn)化酶(ACE)酶聯(lián)免疫試劑盒 | CSB-E04490r | ACE | 31.25 ng/ml - 2000 ng/ml | 7.81 ng/ml |
| 小鼠血管緊張素轉(zhuǎn)化酶(ACE)酶聯(lián)免疫試劑盒 | CSB-E04492m | ACE | 1.56 ng/mL-100 ng/mL | 0.39 ng/mL |
| 人血管緊張素Ⅰ轉(zhuǎn)化酶(ACEⅠ)酶聯(lián)免疫試劑盒 | CSB-E11269h | ACE | 18.75 pg/mL-1200 pg/mL | 4.7 pg/mL |
| 人血管緊張素原(aGT)酶聯(lián)免疫試劑盒 | CSB-E08564h | AGT | 78 pg/mL-5000 pg/mL | 19.5 pg/mL |
| 大鼠血管緊張素原(aGT)酶聯(lián)免疫試劑盒 | CSB-E08565r | AGT | 31.25 pg/mL-2000 pg/mL | 7.81 pg/mL |
| 小鼠血管緊張素原(aGT)酶聯(lián)免疫試劑盒 | CSB-E08566m | AGT | 3.12 ng/mL-200 ng/mL | 0.78 ng/mL |
| 人RACα絲氨酸/蘇氨酸蛋白激酶(AKT1)酶聯(lián)免疫試劑盒 | CSB-EL001553HU | AKT1 | 0.312 ng/mL-20 ng/mL | 0.078 ng/mL |
| 牛白蛋白(ALB)酶聯(lián)免疫試劑盒 | CSB-E08664b | ALB | 0.313 μg/mL-80 μg/mL | 0.148 μg/mL |
| 小鼠白蛋白酶聯(lián)免疫試劑盒 | CSB-E13878m | ALB | 0.781 μg/mL-200 μg/mL | 0.110 μg/mL |
| 犬白蛋白(Alb)酶聯(lián)免疫試劑盒 | CSB-E15757c | ALB | 0.273 μg/mL-35 μg/mL | 0.266 μg/mL |
| 綿羊白蛋白酶聯(lián)免疫試劑盒 | CSB-E15839Sh | ALB | 350 μg/mL-21.88 μg/mL | 5.5 μg/mL |
| 馬白蛋白酶聯(lián)免疫試劑盒 | CSB-E16205Hs | ALB | 1.25 μg/mL-80 μg/mL | 1.247 μg/mL |
| 豬白蛋白酶聯(lián)免疫試劑盒 | CSB-E16207p | ALB | 0.03 μg/mL-7000 μg/mL | 0.03 μg/mL |
| 山羊白蛋白(Alb)酶聯(lián)免疫試劑盒 | CSB-E15758G | ALB | 0.17 μg/mL-350 μg/mL | 0.17 μg/mL |
| 豚鼠白蛋白(ALB)酶聯(lián)免疫試劑盒 | CSB-E15765Gp | ALB | 0.156 μg/mL-10 μg/mL | 0.09 μg/mL |
| 兔白蛋白酶聯(lián)免疫試劑盒 | CSB-E16204Rb | ALB | 0.273 μg/mL-70 μg/mL | 0.117 μg/mL |
| 人單核細(xì)胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒 | CSB-E04655h | CCL2 | 6.25 pg/ml-400 pg/ml. | 1.56 pg/ml. |
| 小鼠單核細(xì)胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒 | CSB-E07430m | CCL2 | 78 pg/mL-5000 pg/mL | 19.5 pg/mL |
| 犬單核細(xì)胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒 | CSB-E15747c | CCL2 | 0.125 ng/mL-8 ng/mL | 0.147 ng/mL |
| 兔子單核細(xì)胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒 | CSB-E06921Rb | CCL2 | 23.5 pg/mL-1500 pg/mL | 5.87 pg/mL |
參考文獻(xiàn)：
[1] https://vizhub.healthdata.org/gbd-results/
[2] https://www.healthdata.org/news-events/newsroom/news-releases/lancet-latest-global-disease-estimates-reveal-perfect-storm
[3] https://www.thelancet.com/pdfs/journals/lancet/PlIS0140-6736(18)31694-5.pdf
[4] https://www.worldkidneyday.org/knowledge-bank-files/wkd-2024-scientific-editorial-mind-the-gap-in-kidney-care-translating-what-we-know-into-what-we-do/
