Recombinant Rabbit G-protein coupled bile acid receptor 1 (GPBAR1)

in vitro E.coli expression system

中文名稱(chēng)：

小圓錐花果GPBAR1重組蛋白
貨號(hào)：

CSB-CF768106RB
說(shuō)明書(shū)：

MSDS Datasheet
規(guī)格：
來(lái)源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

基因名：

GPBAR1
Uniprot No.：

Q862A8
別名：

GPBAR1; TGR5; G-protein coupled bile acid receptor 1
種屬：

Oryctolagus cuniculus (Rabbit)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-330
氨基酸序列

MTPNSTGEVPGPIPRGALELSLALASLIIAANLLLALGIACDRRLRSPPAGCFFLSLLLA GLLTGLALPTLPGLWRQSHRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYVAVLRPLQP PGSIRLALLLTWTGPLLFASLPALGWNHWGPEANCSSQTIFPAPYLYLEVYGLLLPAVGA AALLSAHVLLAAHRQLQDIRRLERAVCRDAPSALARALTWRQARAQAGATLLFGLCWGPY VATLFLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDHRYTAPWRAAARRWLR GLRGRGSQASPGPSTAYHTSSQSSVDVDLN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Receptor for bile acid. Bile-acid binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion.
基因功能參考文獻(xiàn)：
1. TGR5 has been linked to signaling pathways involved in metabolism, cell survival, proliferation and apoptosis, which suggest a possible role of TGR5 in cancer development. PMID: 23782454
亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
組織特異性：

Expressed at high level in spleen. Expressed at lower level in thymus, heart, lung, liver, kidney, ileum, blood and adherent alveolar macrophage cells.
數(shù)據(jù)庫(kù)鏈接：

KEGG: ocu:100009346

STRING: 9986.ENSOCUP00000004791

UniGene: Ocu.3068