GPBAR1

GPBAR1，即G蛋白偶聯(lián)膽汁酸受體1，別名TGR5、GPCR19、hGPCR19、M-BAR、BG37等。它來源于人體細(xì)胞內(nèi)的基因表達(dá)，是G蛋白偶聯(lián)受體家族的一員。GPBAR1的作用機(jī)制主要通過識(shí)別并結(jié)合膽汁酸，激活下游信號(hào)通路，從而參與代謝調(diào)控、炎癥反應(yīng)和能量平衡等生理過程。在生物學(xué)意義上，GPBAR1對(duì)于維持機(jī)體內(nèi)環(huán)境穩(wěn)定、預(yù)防代謝性疾病和炎癥性疾病具有重要意義，同時(shí)也是藥物研發(fā)的重要靶點(diǎn)之一。

熱銷產(chǎn)品

Recombinant Human?G-protein?coupled?bile?acid?receptor?1 (GPBAR1) (CSB-CF819471HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

GPBAR1 Antibody (CSB-PA819471LA01HU)

驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: Mouse kidney tissue
All lanes: GPBAR1 antibody at 6μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 36 kDa
Observed band size: 36 kDa

IHC image of CSB-PA819471LA01HU diluted at 1:300 and staining in paraffin-embedded human bladder cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of 293 cells with CSB-PA819471LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human G protein-coupled bile acid receptor 1(GPBAR1) ELISA Kit (CSB-E13937h)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-E13937h

規(guī)格：96T/48T

靈敏度：0.039 ng/mL

檢測(cè)范圍：0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

GPBAR1 Antibody

GPBAR1 Protein

GPBAR1 ELISA Kit

GPBAR1 Antibodies

GPBAR1 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA007456	GPBAR1 Antibody	Human	ELISA, WB, IHC
CSB-PA819471LA01HU	GPBAR1 Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA819471LB01HU	GPBAR1 Antibody, HRP conjugated	Human	ELISA
CSB-PA819471LC01HU	GPBAR1 Antibody, FITC conjugated	Human
CSB-PA819471LD01HU	GPBAR1 Antibody, Biotin conjugated	Human	ELISA

GPBAR1 Proteins

GPBAR1 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP767305RA1 CSB-EP767305RA1 CSB-BP767305RA1 CSB-MP767305RA1 CSB-EP767305RA1-B	Recombinant Rat G-protein coupled bile acid receptor 1 (Gpbar1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF767305RA	Recombinant Rat G-protein coupled bile acid receptor 1 (Gpbar1)	in vitro E.coli expression system

GPBAR1 Proteins for Oryctolagus cuniculus (Rabbit)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP768106RB1 CSB-EP768106RB1 CSB-BP768106RB1 CSB-MP768106RB1 CSB-EP768106RB1-B	Recombinant Rabbit G-protein coupled bile acid receptor 1 (GPBAR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF768106RB	Recombinant Rabbit G-protein coupled bile acid receptor 1 (GPBAR1)	in vitro E.coli expression system

GPBAR1 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP769663BO1 CSB-EP769663BO1 CSB-BP769663BO1 CSB-MP769663BO1 CSB-EP769663BO1-B	Recombinant Bovine G-protein coupled bile acid receptor 1 (GPBAR1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF769663BO	Recombinant Bovine G-protein coupled bile acid receptor 1 (GPBAR1)	in vitro E.coli expression system

GPBAR1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP773890MO1 CSB-EP773890MO1 CSB-BP773890MO1 CSB-MP773890MO1 CSB-EP773890MO1-B	Recombinant Mouse G-protein coupled bile acid receptor 1 (Gpbar1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF773890MO	Recombinant Mouse G-protein coupled bile acid receptor 1 (Gpbar1)	in vitro E.coli expression system

GPBAR1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP819471HU1 CSB-BP819471HU1 CSB-MP819471HU1 CSB-EP819471HU1-B	Recombinant Human G-protein coupled bile acid receptor 1 (GPBAR1), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF819471HU	Recombinant Human?G-protein?coupled?bile?acid?receptor?1 (GPBAR1)	in vitro E.coli expression system
CSB-EP819471HU1	Recombinant Human G-protein coupled bile acid receptor 1 (GPBAR1), partial	E.coli
CSB-MP819471HU	Recombinant Human G-protein coupled bile acid receptor 1 (GPBAR1)-VLPs	Mammalian cell