Recombinant Rat cAMP-dependent protein kinase type I-alpha regulatory subunit (Prkar1a)

中文名稱：

大鼠Prkar1a重組蛋白
貨號：

CSB-YP018694RA
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Prkar1a重組蛋白
貨號：

CSB-EP018694RA
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Prkar1a重組蛋白
貨號：

CSB-EP018694RA-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Prkar1a重組蛋白
貨號：

CSB-BP018694RA
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Prkar1a重組蛋白
貨號：

CSB-MP018694RA
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Prkar1a
Uniprot No.：

P09456
別名：

Prkar1a; cAMP-dependent protein kinase type I-alpha regulatory subunit [Cleaved into: cAMP-dependent protein kinase type I-alpha regulatory subunit; N-terminally processed]
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

1-381
氨基酸序列

MASGSMAASE EERSLRECEL YVQKHNIQAL LKDSIVQLCT ARPERPMAFL REYFERLEKE EARQIQSLQK SGIRTDSRED EISPPPPNPV VKGRRRRGAI SAEVYTEEDA ASYVRKVIPK DYKTMAALAK AIEKNVLFSH LDDNERSDIF DAMFPVSFIA GETVIQQGDE GDNFYVIDQG EMDVYVNNEW ATSVGEGGSF GELALIYGTP RAATVKAKTN VKLWGIDRDS YRRILMGSTL RKRKMYEEFL SKVSILESLD KWERLTVADA LEPVQFEDGQ KIVVQGEPGD EFFIILEGTA AVLQRRSENE EFVEVGRLGP SDYFGEIALL MNRPRAATVV ARGPLKCVKL DRPRFERVLG PCSDILKRNI QQYNSFVSLS V
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
基因功能參考文獻：
1. role for PKA signaling in both short- and long-term regulation of AQP2, characterizing a novel mouse model of diabetes insipidus PMID: 25587115
2. hypoxia/reoxygenation (H/R)-mediated decrease in PKARIalpha protein levels leads to activation of RSK1, which via phosphorylation of NHE1 induces cardiomyocyte apoptosis. PMID: 24307699
3. a key role for AKAP-targeted PKA in control of heart rate and contractile function PMID: 20581396
4. cAMP-Dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes PMID: 11818504
5. oocytes express AKAP140 that is phosphorylated during meiosis. AKAP140 and its phosphorylation state may influence the translocation of the R subunits of PKA throughout resumption of meiosis. PMID: 12088872
6. GABA B receptor-mediated inhibitory action on GABA release was mediated via decreases in protein kinase A activity. PMID: 12815184
7. protein kinase A is controlled by Fos-related antigen 2 and has a role in inducing CCAAT/enhancer-binding protein beta expression in osteoblasts PMID: 15299028
8. the PKA RIalpha subunit dynamic C helix mediates isoform-specific domain reorganization upon C subunit binding PMID: 16109722
9. dystrobrevin is a scaffold protein that may play a role in different cellular processes involving PKA signaling PMID: 17610895
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亞細胞定位：

Cell membrane.
蛋白家族：

CAMP-dependent kinase regulatory chain family
數據庫鏈接：

KEGG: rno:25725

STRING: 10116.ENSRNOP00000067771

UniGene: Rn.10990