Recombinant Mouse cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Pde4a), partial

中文名稱：

小鼠Pde4a重組蛋白
貨號：

CSB-YP526024MO
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Pde4a重組蛋白
貨號：

CSB-EP526024MO
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Pde4a重組蛋白
貨號：

CSB-EP526024MO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Pde4a重組蛋白
貨號：

CSB-BP526024MO
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Pde4a重組蛋白
貨號：

CSB-MP526024MO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Pde4a
Uniprot No.：

O89084
別名：

Pde4a; cAMP-specific 3',5'-cyclic phosphodiesterase 4A; EC 3.1.4.53
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
基因功能參考文獻：
1. In conclusion, our data demonstrated that UFM24 inhibits oxidative burst in human neutrophils through inhibition of PDE4 activity. UFM24 also exhibited significant protection against endotoxin-induced acute lung injury (ALI)in mice. UFM24 has potential as an anti-inflammatory agent for treating neutrophilic lung damage. PMID: 28263828
2. PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner. PMID: 25640159
3. results suggest that PDE4A may be important in the regulation of emotional memory and anxiety-like behavior, but not emesis PMID: 24563185
4. Increased cAMP may remodel cAMP-mediated signalling events by not only increasing the expression of specific PDE4 cAMP phosphodiesterases but also by down-regulating specific isoforms, such as is shown here for PDE4A10 in cardiac myocytes. PMID: 18721873
5. a new mechanism in which phosphodiesterase PDE4A4/5 interacts with p75(NTR) to enhance cAMP degradation PMID: 17576803
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亞細胞定位：

Cytoplasm, perinuclear region.
蛋白家族：

Cyclic nucleotide phosphodiesterase family, PDE4 subfamily
數據庫鏈接：

KEGG: mmu:18577

STRING: 10090.ENSMUSP00000037025

UniGene: Mm.191749