Recombinant Macaca fascicularis Trophoblast glycoprotein (TPBG), partial (Active)

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中文名稱：

獼猴TPBG重組蛋白
品名簡稱：

Recombinant Cynomolgus monkey TPBG protein, partial (Active)
貨號：

CSB-MP024093MOV
說明書：

MSDS Datasheet
規格：

￥828
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis TPBG at 2 μg/mL can bind Anti-TPBG recombinant antibody (CSB-RA024093MA1HU), the EC₅₀ is 1.672-2.181 ng/mL.
促銷：
其他：

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靶點詳情

產品詳情

純度：

Greater than 95% as determined by SDS-PAGE.
內毒素：

Less than 1.0 EU/ug as determined by LAL method.
生物活性：

Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis TPBG at 2 μg/mL can bind Anti-TPBG recombinant antibody (CSB-RA024093MA1HU), the EC50 is 1.672-2.181 ng/mL.
基因名：

TPBG
Uniprot No.：

Q4R8Y9
別名：

(Wnt-activated inhibitory factor 1)(WAIF1)
分子結構：
種屬：

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
蛋白長度：

Partial
來源：

Mammalian cell
分子量：

39.9 kDa
表達區域：

35-355aa
氨基酸序列

TSSASSSSSSAPFLASAASAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPLYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRGGAFEHLPSLRQLDLSHNPLAYLSPFAFSGSNASISAPSPLVELILNHIVPPDDKRQNRSFEGMVAAALVAGRALQGLHLLELASNHFLYLPRDVLAQLPSLRYLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHVRVFLDNNPWVCDCHMADMVTWLKQTGVVQGKDRLTCAFPEKMRNRVLLELNSADLDCDPILPPSLQTS
蛋白標簽：

N-terminal?10xHis-tagged?and?C-terminal?Myc-tagged
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
產品描述：

This Macaca fascicularis TPBG recombinant protein was produced in mammalian cell, where the gene sequence encoding Macaca fascicularis TPBG (35-355aa) was expressed with the N-terminal 10xHis tag and C-terminal Myc tag. The purity of this TPBG protein was greater than 95%. The activity was tested.

TPBG is expressed on a variety of malignancies, but has limited expression in normal adult tissues. At present, the global TPBG research pipeline is not very dense, and it is scattered in various drug types (vaccine, ADCs, bispecific antibodies, fusion protein, etc.). Drug candidates targeting TPBG have demonstrated good preclinical antitumor activity and safety, indicating that TPBG is a very attractive target in tumor immunotherapy. The preparation of Macaca fascicularis TPBG recombinant protein can help its related drug development and research.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
數據庫鏈接：

KEGG: mcf:102132149

UniGene: Mfa.1408