Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-4 (Cacna2d4), partial

中文名稱：

Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-4(Cacna2d4) ,partial
貨號：

CSB-YP719321MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-4(Cacna2d4) ,partial
貨號：

CSB-EP719321MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-4(Cacna2d4) ,partial
貨號：

CSB-EP719321MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-4(Cacna2d4) ,partial
貨號：

CSB-BP719321MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Voltage-dependent calcium channel subunit alpha-2/delta-4(Cacna2d4) ,partial
貨號：

CSB-MP719321MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Cacna2d4
Uniprot No.：

Q5RJF7
別名：

Cacna2d4; Voltage-dependent calcium channel subunit alpha-2/delta-4; Voltage-gated calcium channel subunit alpha-2/delta-4) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4]
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel.
基因功能參考文獻：
1. Eliminating a2d4 in mice abolishes rod synaptogenesis and synaptic transmission to rod ON bipolar cells, and disrupts postsynaptic mGluR6 clustering. Further find , a2d4 is crucial for organizing synaptic ribbons and setting CaV1.4 voltage sensitivity. In cones, a2d4 is essential for CaV1.4 function, but is not required for ribbon organization, synaptogenesis, or synaptic transmission. PMID: 28262416
2. alpha2delta4 E25b splicing variant is normally present in mouse retina and mimics the effect of c.2451insC mutation. PMID: 26218913
3. The Cacna2d4 mutation underlies a novel channelopathy leading to cone-rod dysfunction in the visual system of mice PMID: 16877424
相關疾病：

Defects in Cacna2d4 are a cause of cone-rod dysfunction. Mice display affected retinal ribbon-type synapses. The retinopathy is accompanied by a substantial loss in the activities of the second-order neurons. Rod photoreceptor responses are maintained with reduced amplitude, whereas cone activities are absent.
亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Calcium channel subunit alpha-2/delta family
數據庫鏈接：

KEGG: mmu:319734

STRING: 10090.ENSMUSP00000044660

UniGene: Mm.440773