Recombinant Human Tripartite motif-containing protein 38 (TRIM38)

中文名稱：

人TRIM38重組蛋白
貨號：

CSB-YP024475HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人TRIM38重組蛋白
貨號：

CSB-EP024475HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人TRIM38重組蛋白
貨號：

CSB-EP024475HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TRIM38重組蛋白
貨號：

CSB-BP024475HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人TRIM38重組蛋白
貨號：

CSB-MP024475HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

TRIM38
Uniprot No.：

O00635
別名：

TRIM38; RNF15; RORET; E3 ubiquitin-protein ligase TRIM38; EC 2.3.2.27; RING finger protein 15; RING-type E3 ubiquitin transferase TRIM38; Tripartite motif-containing protein 38; Zinc finger protein RoRet
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區(qū)域：

1-465
氨基酸序列

MASTTSTKKM MEEATCSICL SLMTNPVSIN CGHSYCHLCI TDFFKNPSQK QLRQETFCCP QCRAPFHMDS LRPNKQLGSL IEALKETDQE MSCEEHGEQF HLFCEDEGQL ICWRCERAPQ HKGHTTALVE DVCQGYKEKL QKAVTKLKQL EDRCTEQKLS TAMRITKWKE KVQIQRQKIR SDFKNLQCFL HEEEKSYLWR LEKEEQQTLS RLRDYEAGLG LKSNELKSHI LELEEKCQGS AQKLLQNVND TLSRSWAVKL ETSEAVSLEL HTMCNVSKLY FDVKKMLRSH QVSVTLDPDT AHHELILSED RRQVTRGYTQ ENQDTSSRRF TAFPCVLGCE GFTSGRRYFE VDVGEGTGWD LGVCMENVQR GTGMKQEPQS GFWTLRLCKK KGYVALTSPP TSLHLHEQPL LVGIFLDYEA GVVSFYNGNT GCHIFTFPKA SFSDTLRPYF QVYQYSPLFL PPPGD
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.
基因功能參考文獻：
1. Data suggest that mRNA/protein levels of NLRP6 are down-regulated in synovial tissues and synoviocytes of rheumatoid arthritis (RA) patients compared to osteoarthritis patients; NLRP6 provides docking site to facilitate interaction between TAB2/3 and TRIM38 in RA synoviocytes in response to TNFalpha. (NLRP6 = ; TAB2/3 = transforming growth factor-b-activated kinase 1-binding protein 2/3; TRIM38 = tripartite motif 38) PMID: 28295271
2. TRIM38 may act as a novel negative regulator for TLR3-mediated type I interferon signaling by targeting TRIF for degradation PMID: 23056470
3. NF-kappaB is activated in response to TRIM38. PMID: 21789858
4. Enterovirus 71 infection induces degradation of TRIM38. PMID: 21306652
組織特異性：

Ubiquitous.
數(shù)據(jù)庫鏈接：

HGNC: 10059

KEGG: hsa:10475

STRING: 9606.ENSP00000230099

UniGene: Hs.584851