TRIM38 Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

O00635
基因名：

TRIM38
別名：

TRIM38 antibody; RNF15 antibody; RORET antibody; E3 ubiquitin-protein ligase TRIM38 antibody; EC 2.3.2.27 antibody; RING finger protein 15 antibody; RING-type E3 ubiquitin transferase TRIM38 antibody; Tripartite motif-containing protein 38 antibody; Zinc finger protein RoRet antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human RNF15.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:40000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling.
基因功能參考文獻(xiàn)：
1. Data suggest that mRNA/protein levels of NLRP6 are down-regulated in synovial tissues and synoviocytes of rheumatoid arthritis (RA) patients compared to osteoarthritis patients; NLRP6 provides docking site to facilitate interaction between TAB2/3 and TRIM38 in RA synoviocytes in response to TNFalpha. (NLRP6 = ; TAB2/3 = transforming growth factor-b-activated kinase 1-binding protein 2/3; TRIM38 = tripartite motif 38) PMID: 28295271
2. TRIM38 may act as a novel negative regulator for TLR3-mediated type I interferon signaling by targeting TRIF for degradation PMID: 23056470
3. NF-kappaB is activated in response to TRIM38. PMID: 21789858
4. Enterovirus 71 infection induces degradation of TRIM38. PMID: 21306652
組織特異性：

Ubiquitous.
數(shù)據(jù)庫鏈接：

HGNC: 10059

KEGG: hsa:10475

STRING: 9606.ENSP00000230099

UniGene: Hs.584851

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