Recombinant Human Ribonucleases P/MRP protein subunit POP1 (POP1), partial

中文名稱：

人POP1重組蛋白
貨號：

CSB-YP857865HU
規格：
來源：

Yeast
其他：

中文名稱：

人POP1重組蛋白
貨號：

CSB-EP857865HU
規格：
來源：

E.coli
其他：

中文名稱：

人POP1重組蛋白
貨號：

CSB-EP857865HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人POP1重組蛋白
貨號：

CSB-BP857865HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人POP1重組蛋白
貨號：

CSB-MP857865HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

POP1
Uniprot No.：

Q99575
別名：

4932434G09Rik; hPOP1; KIAA0061; MGC17365; MGC36536; POP1; POP1_HUMAN; Processing of precursor 1; Processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae); Processing of precursors 1; Ribonucleases P/MRP protein subunit homolog; Ribonucleases P/MRP protein subunit POP1
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
基因功能參考文獻：
1. Biallelic POP1 mutations were identified in both. A missense mutation and a novel single base deletion were detected in proband 1, p.[Pro582Ser]:[Glu870fs*5]. Markedly reduced abundance of RMRP and elevated levels of pre5.8s rRNA was observed. In proband 2, a homozygous novel POP1 mutation was identified PMID: 28067412
2. we reported the third case with POP1-related AAD. This phenotype may appropriately be termed AAD type 2. PMID: 27380734
3. by inhibiting inflammasome assembly, provides a regulatory feedback loop that shuts down excessive inflammatory responses; Cryopyrin-Associated Periodic Syndrome patients exhibit reduced expression PMID: 26275995
4. S-palmitoylation alters conformation or secondary structure of Trx1, as well as decreases the ability of Trx1 to transfer electrons from thioredoxin reductase to S-nitrosylated protein-tyrosine phosphatase 1B and S-nitroso-glutathione PMID: 25839653
5. Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-trna 5' processing. PMID: 22991464
6. POP1 gene expression is increased in classic variant of papillary thyroid carcinoma. PMID: 21509594
7. A transient association of protein subunits may be inversely correlated to its involvement in pre-rRNA processing. PMID: 16723659
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相關疾病：

Anauxetic dysplasia 2 (ANXD2)
亞細胞定位：

Nucleus, nucleolus.
數據庫鏈接：

HGNC: 30129

OMIM: 602486

KEGG: hsa:10940

STRING: 9606.ENSP00000339529

UniGene: Hs.252828