Recombinant Human GRIP1-associated protein 1 (GRIPAP1), partial

中文名稱：

人GRIPAP1重組蛋白
貨號：

CSB-YP690136HU
規格：
來源：

Yeast
其他：

中文名稱：

人GRIPAP1重組蛋白
貨號：

CSB-EP690136HU
規格：
來源：

E.coli
其他：

中文名稱：

人GRIPAP1重組蛋白
貨號：

CSB-EP690136HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人GRIPAP1重組蛋白
貨號：

CSB-BP690136HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人GRIPAP1重組蛋白
貨號：

CSB-MP690136HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

GRIPAP1
Uniprot No.：

Q4V328
別名：

DKFZp434P0630; DXImx47e; GRAP1_HUMAN; GRASP 1; GRASP-1; GRASP1; GRIP 1 associated protein 1; GRIP associated protein 1 ; GRIP1 associated protein 1; GRIP1-associated protein 1; GRIPAP 1; GRIPAP1; KIAA1167; MGC126593; MGC126595; MPMGp800B12492Q3; Sfc10; TAMALIN
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity.; Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity.
基因功能參考文獻：
1. We identified a new TFE3 fusion partner, GRIPAP1, in translocation renal cell carcinoma PMID: 28106924
2. results demonstrate a requirement for normal recycling endosome function in AMPAR-dependent synaptic function and neuronal connectivity in vivo, and suggest a potential role for GRASP1 in the pathophysiology of human cognitive disorders. PMID: 28285821
3. GRASP-1 was identified as an soluble autoantigen that has numerous coiled-coil domains throughout the protein. PMID: 15897011
4. Results suggest that GRASP-1 serves as a scaffold protein to facilitate MEKK-1 activation of JNK signaling in neurons. PMID: 17761173
亞細胞定位：

Early endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse.
數據庫鏈接：

HGNC: 18706

OMIM: 300408

KEGG: hsa:56850

STRING: 9606.ENSP00000365624

UniGene: Hs.109929