Recombinant Human Fibrillin-3 (FBN3), partial

中文名稱：

人FBN3重組蛋白
貨號(hào)：

CSB-YP758811HU
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

人FBN3重組蛋白
貨號(hào)：

CSB-EP758811HU
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

人FBN3重組蛋白
貨號(hào)：

CSB-EP758811HU-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人FBN3重組蛋白
貨號(hào)：

CSB-BP758811HU
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

人FBN3重組蛋白
貨號(hào)：

CSB-MP758811HU
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

FBN3
Uniprot No.：

Q75N90
別名：

FBN3; KIAA1776Fibrillin-3 [Cleaved into: Fibrillin-3 C-terminal peptide]
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-containing microfibrils provide long-term force bearing structural support.
基因功能參考文獻(xiàn)：
1. an association study showed a potential association of the D19S884 marker with PCOS in Chinese Han women and the meta-analysis identified that the A8 allele may increase susceptibility to PCOS PMID: 23265956
2. The FBN3 risk allele may be associated with changes in basal glucose homeostasis in PCOS. PMID: 22301903
3. Data show that TGF-beta pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries. PMID: 21411746
4. fibrillin-3, compared to the other fibrillins, fulfills both overlapping and distinct functions in human development PMID: 20970500
5. A variant in the fibrillin-3 gene is associated with TGF-beta and inhibin B levels in women with polycystic ovary syndrome. PMID: 20630504
6. Loss of fibrillin-3 during folliculogenesis may be an important factor in polycystic ovary syndrome pathogenesis. PMID: 20855553
7. Single nucleotide polymorphisms in FBN3 occur and may be a candidate gene for polycystic ovary syndrome. PMID: 20200332
8. Data show that fibrillin 3 appears to have little involvement in PCOS but cannot rule out that other markers in the region of chromosome 19p13.2 are associated with PCOS or that FBN3 expression occurs in other organs that may influence the PCOS phenotype. PMID: 19692420
9. fibrillin-3 gene showed the strongest evidence for association with Polycystic ovary syndrome PMID: 17785364
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亞細(xì)胞定位：

Secreted, extracellular space, extracellular matrix.
蛋白家族：

Fibrillin family
組織特異性：

Predominantly expressed in connective tissues such as skeletal muscle, tendon, skin, perichondrium and periosteum. Highly expressed in fetal lung, brain, kidney. Expressed at low level in prostate, testis, mammary gland, uterus, ovary, placenta, bladder,
數(shù)據(jù)庫(kù)鏈接：

HGNC: 18794

OMIM: 608529

KEGG: hsa:84467

STRING: 9606.ENSP00000270509

UniGene: Hs.370362