Recombinant Human Collectin-10 (COLEC10)

中文名稱：

Recombinant Human Collectin-10(COLEC10)
貨號：

CSB-YP896556HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Collectin-10(COLEC10)
貨號：

CSB-EP896556HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Collectin-10(COLEC10)
貨號：

CSB-BP896556HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Collectin-10(COLEC10)
貨號：

CSB-MP896556HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

COLEC10
Uniprot No.：

Q9Y6Z7
別名：

CL-34; CL-L1; CLL1; COL10_HUMAN; Colec10; Collectin liver 1; Collectin liver protein 1; Collectin sub family member 10 (C-type lectin); Collectin sub family member 10; Collectin subfamily member 10; Collectin-10; Collectin-34; MGC118794; MGC118795; OTTHUMP00000228058
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

28-277
氨基酸序列

LDI DSRPTAEVCA THTISPGPKG DDGEKGDPGE EGKHGKVGRM GPKGIKGELG DMGDQGNIGK TGPIGKKGDK GEKGLLGIPG EKGKAGTVCD CGRYRKFVGQ LDISIARLKT SMKFVKNVIA GIRETEEKFY YIVQEEKNYR ESLTHCRIRG GMLAMPKDEA ANTLIADYVA KSGFFRVFIG VNDLEREGQY MFTDNTPLQN YSNWNEGEPS DPYGHEDCVE MLSSGRWNDT ECHLTMYFVC EFIKKKK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Acts as a chemoattractant, probably involved in the regulation of cell migration.
基因功能參考文獻：
1. High CLL1 expression is associated with cardiovascular disease. PMID: 27341702
2. Exome sequencing reveals mutations in collectin sub-family member 10 (C-type lectin) protein (COLEC10) as a cause of 3MC syndrome with main features include facial dysmorphism, craniosynostosis and cleft lip/palate. PMID: 28301481
3. high serum CL-L1 concentration in critically ill children upon PICU admission is associated with an increased risk of infection and prolonged need of intensive care, and counteracts the protective effect of having a high MASP-3 concentration PMID: 27057739
4. Data indicate differences in the plasma concentrations of collectin liver 1 and collectin kidney 1, M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls. PMID: 26154564
5. Carriers of COLEC10 Arg125Trp had increased CL-L1 serum levels. PMID: 25710878
6. Most plasma CL-K1 was found in complex with CL-L1 in a ratio suggesting a heteromeric subunit of 1 CL-L1 & 2 CL-K1 polypeptides. PMID: 24174618
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相關疾病：

3MC syndrome 3 (3MC3)
亞細胞定位：

Secreted. Golgi apparatus. Cytoplasm.
蛋白家族：

COLEC10/COLEC11 family
組織特異性：

Highly expressed in liver, placenta and adrenal gland. Moderately expressed in small intestine, lung, stomach and prostate. Weakly expressed in trachea and spleen.
數據庫鏈接：

HGNC: 2220

OMIM: 248340

KEGG: hsa:10584

STRING: 9606.ENSP00000332723

UniGene: Hs.176615