Human Collectin-10(COLEC10) ELISA kit

Human Collectin-10(COLEC10) ELISA kit

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中文名稱：

人膠原凝集素-10(COLEC10)酶聯免疫試劑盒
貨號：

CSB-EL005760HU
規格：

96T/48T
價格：

￥3600/￥2500
其他：

CUSABIO Wins 2024 Bioz Rapid Star? Award in the ELISA category

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人膠原凝集素-10(COLEC10)酶聯免疫試劑盒（CSB-EL005760HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的COLEC10含量。COLEC10是一種C型凝集素家族成員，主要在肝星狀細胞中表達，參與肝纖維化的發病機制。其功能涉及免疫反應和炎癥過程，可能通過識別病原體相關分子模式（PAMP）和損傷相關分子模式（DAMP）來激活免疫細胞，增強宿主對感染的防御。試劑盒檢測范圍為23.44 pg/mL-1500 pg/mL，適用于細胞生物學、免疫學及疾病機制研究中COLEC10的表達動態分析，例如炎癥模型構建、病原體感染應答研究或腫瘤相關分子網絡探索。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
別名：

CL-34 ELISA Kit; CL-L1 ELISA Kit; CLL1 ELISA Kit; COL10_HUMAN ELISA Kit; Colec10 ELISA Kit; Collectin liver 1 ELISA Kit; Collectin liver protein 1 ELISA Kit; Collectin sub family member 10 (C-type lectin) ELISA Kit; Collectin sub family member 10 ELISA Kit; Collectin subfamily member 10 ELISA Kit; Collectin-10 ELISA Kit; Collectin-34 ELISA Kit; MGC118794 ELISA Kit; MGC118795 ELISA Kit; OTTHUMP00000228058 ELISA Kit
縮寫：

COLEC10
Uniprot No.：

Q9Y6Z7
種屬：

Homo sapiens (Human)
樣本類型：

serum, plasma, tissue homogenates
檢測范圍：

23.44 pg/mL-1500 pg/mL
靈敏度：

5.86 pg/mL
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Immunology
測定原理：

quantitative
測定方法：

Sandwich

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of human COLEC10 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:1	Average %	87
	Range %	81-92
1:2	Average %	92
	Range %	83-98
1:4	Average %	97
	Range %	93-101
1:8	Average %	95
	Range %	87-99

回收率：

The recovery of human COLEC10 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	96	92-102
EDTA plasma (n=4)	88	82-94

標準曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

pg/ml	OD1	OD2	Average	Corrected
1500	2.880	2.964	2.922	2.814
750	2.541	2.427	2.484	2.376
375	1.832	1.734	1.783	1.675
187.5	0.997	0.972	0.985	0.877
93.75	0.533	0.554	0.544	0.436
46.88	0.380	0.376	0.378	0.270
23.44	0.254	0.258	0.256	0.148
0	0.107	0.108	0.108

數據處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

COLEC10 and COLEC11 are new serum biomarkers of chronic liver disease M Zhang, Y Jing, K Li, M Wang, S Ju, Z Zhou, X Cao,scientific reports,2025
Serum Proteomic Analysis by Tandem Mass Tag-Based Quantitative Proteomics in Pediatric Obstructive Sleep Apnea Hanrong Cheng,Frontiers in Molecular Biosciences,2022

功能：

Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Acts as a chemoattractant, probably involved in the regulation of cell migration.
基因功能參考文獻：
1. High CLL1 expression is associated with cardiovascular disease. PMID: 27341702
2. Exome sequencing reveals mutations in collectin sub-family member 10 (C-type lectin) protein (COLEC10) as a cause of 3MC syndrome with main features include facial dysmorphism, craniosynostosis and cleft lip/palate. PMID: 28301481
3. high serum CL-L1 concentration in critically ill children upon PICU admission is associated with an increased risk of infection and prolonged need of intensive care, and counteracts the protective effect of having a high MASP-3 concentration PMID: 27057739
4. Data indicate differences in the plasma concentrations of collectin liver 1 and collectin kidney 1, M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls. PMID: 26154564
5. Carriers of COLEC10 Arg125Trp had increased CL-L1 serum levels. PMID: 25710878
6. Most plasma CL-K1 was found in complex with CL-L1 in a ratio suggesting a heteromeric subunit of 1 CL-L1 & 2 CL-K1 polypeptides. PMID: 24174618
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相關疾?。?/div>
3MC syndrome 3 (3MC3)
亞細胞定位：

Secreted. Golgi apparatus. Cytoplasm.
蛋白家族：

COLEC10/COLEC11 family
組織特異性：

Highly expressed in liver, placenta and adrenal gland. Moderately expressed in small intestine, lung, stomach and prostate. Weakly expressed in trachea and spleen.
數據庫鏈接：

HGNC: 2220

OMIM: 248340

KEGG: hsa:10584

STRING: 9606.ENSP00000332723

UniGene: Hs.176615

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.