COLEC10 Antibody

文獻引用 (1) 說明書

中文名稱：

COLEC10兔多克隆抗體
貨號：

CSB-PA896556LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA896556LA01HU diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA896556LA01HU diluted at 1:300 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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產品詳情
產品評價
引用文獻
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) COLEC10 Polyclonal antibody
Uniprot No.：

Q9Y6Z7
基因名：

COLEC10
別名：

CL-34 antibody; CL-L1 antibody; CLL1 antibody; COL10_HUMAN antibody; Colec10 antibody; Collectin liver 1 antibody; Collectin liver protein 1 antibody; Collectin sub family member 10 (C-type lectin) antibody; Collectin sub family member 10 antibody; Collectin subfamily member 10 antibody; Collectin-10 antibody; Collectin-34 antibody; MGC118794 antibody; MGC118795 antibody; OTTHUMP00000228058 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Collectin-10 protein (28-277AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，COLEC10 Antibody (CSB-PA896556LA01HU)，的標記方式是Non-conjugated。對于COLEC10 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA896556LB01HU	COLEC10 Antibody, HRP conjugated	ELISA
FITC	CSB-PA896556LC01HU	COLEC10 Antibody, FITC conjugated
Biotin	CSB-PA896556LD01HU	COLEC10 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

The C-type lectin COLEC10 is predominantly produced by hepatic stellate cells and involved in the pathogenesis of liver fibrosis M Zhang,Cell death & disease,2023

產品評價

靶點詳情

功能：

Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Acts as a chemoattractant, probably involved in the regulation of cell migration.
基因功能參考文獻：
1. High CLL1 expression is associated with cardiovascular disease. PMID: 27341702
2. Exome sequencing reveals mutations in collectin sub-family member 10 (C-type lectin) protein (COLEC10) as a cause of 3MC syndrome with main features include facial dysmorphism, craniosynostosis and cleft lip/palate. PMID: 28301481
3. high serum CL-L1 concentration in critically ill children upon PICU admission is associated with an increased risk of infection and prolonged need of intensive care, and counteracts the protective effect of having a high MASP-3 concentration PMID: 27057739
4. Data indicate differences in the plasma concentrations of collectin liver 1 and collectin kidney 1, M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls. PMID: 26154564
5. Carriers of COLEC10 Arg125Trp had increased CL-L1 serum levels. PMID: 25710878
6. Most plasma CL-K1 was found in complex with CL-L1 in a ratio suggesting a heteromeric subunit of 1 CL-L1 & 2 CL-K1 polypeptides. PMID: 24174618
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相關疾病：

3MC syndrome 3 (3MC3)
亞細胞定位：

Secreted. Golgi apparatus. Cytoplasm.
蛋白家族：

COLEC10/COLEC11 family
組織特異性：

Highly expressed in liver, placenta and adrenal gland. Moderately expressed in small intestine, lung, stomach and prostate. Weakly expressed in trachea and spleen.
數據庫鏈接：

HGNC: 2220

OMIM: 248340

KEGG: hsa:10584

STRING: 9606.ENSP00000332723

UniGene: Hs.176615

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