MELTF Recombinant Monoclonal Antibody

說明書

中文名稱：

MELTF Recombinant Monoclonal Antibody
貨號：

CSB-RA013754MA1HU
規格：

￥1320
圖片：
The Binding Activity of Human MELTF with Anti-MELTF Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human MELTF (CSB-MP013754HU1) at 2 μg/mL can bind Anti-MELTF recombinant antibody. The EC₅₀ is 0.3476-0.4529 ng/mL.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

Uniprot No.：

P08582
基因名：

MELTF
別名：

Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228), MELTF, MAP97 MFI2
反應種屬：

Human
免疫原：

Recombinant Human MELTF protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

hIgG1
純化方式：

Affinity-chromatography
克隆號：

4A11
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:5000-1:50000

Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.
基因功能參考文獻：
1. Melanotransferrin is a serological marker of colorectal cancer by secretome analysis and quantitative proteomics. PMID: 25216327
2. PC3 tumors are sustained by a small number of tumor-initiating cells with stem-like characteristics, including strong self-renewal and pro-angiogenic capability and marked by the expression pattern FAM65Bhigh/MFI2low/LEF1low. PMID: 21190562
3. The human genome contains a second melanotransferrin gene (MTf2). There are two isoforms of melanotransferrin. PMID: 11852110
4. its ability to donate 59Fe to SK-Mel-28 melanoma cells and other cell types PMID: 12230555
5. membrane-bound and soluble p97 affect the migration capacity of endothelial and melanoma cells and suggest that p97 could be involved in the regulation of plasminogen activation by interacting with pro-uPA and plasminogen. PMID: 12750156
6. Serum melanotransferrin exists in various conformations depending on the binding of bivalent cations or following post-translational modification; serum melanotransferrin levels are unchanged in subjects with Alzheimer's disease. PMID: 12809550
7. The distribution of MTf and its splice variants may provide clues to their possible biological roles in melanoma and other tumors. PMID: 15716025
8. melanotransferrin has a role in cell proliferation and tumorigenesis PMID: 16704991
9. Anti-angiogenic properties of soluble melanotransferrin may result from local overstimulation of plasminogen activation by tissue plasminogen activator, thus leading to subsequent degradation of the fibronectin matrix and endothelial cell detachment. PMID: 16713448
10. Altogether, these findings strongly suggest that MTf overexpression in melanoma cells contributes to tumor progression by stimulating plasmin generation as well as cell migration and invasion. PMID: 17196552
11. HMB-45 (melanoma-associated antigen p97) and Melan-A combined were positive in 100% of the renal angiomyolipomas PMID: 17227112
12. Novel molecular targets directly or indirectly regulated by MTf and the potential pathways involved in its function, including modulation of proliferation. PMID: 17449903
13. this review discusses the studies that have demonstrated that melanotransferrin is not involved in iron metabolism, but plays a vital role in melanoma cell proliferation and tumorigenesis. PMID: 17452986
14. Biochemical and spectroscopic studies of MTF1 are reported. PMID: 18691669
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亞細胞定位：

[Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.
蛋白家族：

Transferrin family
組織特異性：

Found predominantly in human melanomas and in certain fetal tissues; also found in liver, epithelium, umbilical chord, placenta and sweat gland ducts.
數據庫鏈接：

HGNC: 7037

OMIM: 155750

KEGG: hsa:4241

STRING: 9606.ENSP00000296350

UniGene: Hs.184727

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