LEFTY2 Recombinant Monoclonal Antibody
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中文名稱：LEFTY2重組抗體
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貨號(hào)：CSB-RA171603A0HU
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規(guī)格：￥1320
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圖片：
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Western Blot
Positive WB detected in: Ntera-2 whole cell lysate, Hela whole cell lysate
All lanes: LEFTY2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 41, 38 kDa
Observed band size: 36-45 kDa
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：CSB-RA171603A0HU LEFTY2 Recombinant Monoclonal Antibody是針對(duì)發(fā)育調(diào)控關(guān)鍵因子LEFTY2設(shè)計(jì)的高特異性檢測工具。該抗體靶向的LEFTY2蛋白屬于TGF-β超家族成員，在胚胎左右軸模式形成、組織器官發(fā)育及細(xì)胞命運(yùn)決定中發(fā)揮重要作用，同時(shí)參與腫瘤微環(huán)境調(diào)控等病理過程。經(jīng)嚴(yán)格驗(yàn)證，本重組單克隆抗體在Western Blot（WB）實(shí)驗(yàn)中表現(xiàn)出優(yōu)異的靶標(biāo)識(shí)別能力，推薦使用稀釋比為1:500-1:2000時(shí)能清晰檢測目標(biāo)蛋白表達(dá)，同時(shí)在ELISA平臺(tái)也具備可靠檢測性能，適用于多種哺乳動(dòng)物細(xì)胞裂解液或組織樣本的分析。研究人員可利用該抗體探索胚胎發(fā)育異常機(jī)制、干細(xì)胞分化調(diào)控以及腫瘤發(fā)生發(fā)展過程中LEFTY2介導(dǎo)的信號(hào)通路，特別是在研究器官不對(duì)稱發(fā)育、癌癥細(xì)胞侵襲轉(zhuǎn)移抑制、以及TGF-β超家族配體互作網(wǎng)絡(luò)等領(lǐng)域具有重要應(yīng)用價(jià)值。該產(chǎn)品采用重組表達(dá)技術(shù)保證批次穩(wěn)定性，為發(fā)育生物學(xué)、腫瘤學(xué)及細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)研究提供高質(zhì)量的實(shí)驗(yàn)保障。
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Uniprot No.：
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基因名：
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別名：Left-right determination factor 2 (Endometrial bleeding-associated factor) (Left-right determination factor A) (Protein lefty-2) (Protein lefty-A) (Transforming growth factor beta-4) (TGF-beta-4), LEFTY2, EBAF LEFTA LEFTYA TGFB4
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反應(yīng)種屬：Human
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免疫原：A synthesized peptide derived from human LEFTY2
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號(hào)：10G2
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
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基因功能參考文獻(xiàn)：
- functional role of LEFTY during progesterone therapy for endometrial carcinoma PMID: 29268772
- LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage. PMID: 27404958
- LEFTY2 down-regulates MKi67 expression and FAK activity, up-regulates miR-200a and E-cadherin, and is thus a powerful negative regulator of endometrial cell proliferation and migration. PMID: 27497669
- LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1. PMID: 27606670
- Lefty A may account for the tumor suppressive activity of human adult stem cells. PMID: 22469982
- Findings suggest that Lefty2 is negatively modulated by miR-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification. PMID: 21266536
- Findings show that during embryonic development, EBAF/LEFTY B plays important roles in decidualization and embryo implantation. PMID: 21401636
- findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression PMID: 9230066
- may provide a crucial signal for endometrial breakdown and bleeding by triggering expression of several matrix metalloproteinases PMID: 12215426
- nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells PMID: 15308665
- Addition of recombinant LEFTY-A to explants induced MMP-9 in most samples, a response prevented by ovarian steroids. PMID: 15536155
- LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation. PMID: 17038673
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相關(guān)疾病：Left-right axis malformations (LRAM)
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亞細(xì)胞定位：Secreted.
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蛋白家族：TGF-beta family
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組織特異性：Mesenchymal cells of the endometrial stroma.
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數(shù)據(jù)庫鏈接：
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