LEFTY2 Antibody
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中文名稱(chēng)：LEFTY2兔多克隆抗體
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貨號(hào)：CSB-PA012858GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：EBAF antibody; Endometrial bleeding associated factor (left right determination factor A transforming growth factor beta superfamily) antibody; Endometrial bleeding associated factor antibody; Endometrial bleeding-associated factor antibody; Left right determination factor 2 antibody; Left right determination factor A antibody; Left-right determination factor 2 antibody; Left-right determination factor A antibody; LEFTA antibody; LEFTY 2 antibody; LEFTY2 antibody; LEFTYA antibody; LFTY2 transforming growth factor; beta -4 antibody; LFTY2; mouse; homolog of antibody; LFTY2_HUMAN antibody; MGC46222 antibody; Protein lefty 2 antibody; Protein lefty A antibody; Protein lefty-2 antibody; Protein lefty-A antibody; Protein lefty2 antibody; PSEC0024 antibody; TGF beta 4 antibody; TGF-beta-4 antibody; TGFB4 antibody; Transforming growth factor beta 4 antibody; Transforming growth factor beta-4 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human LEFTY2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
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基因功能參考文獻(xiàn)：
- functional role of LEFTY during progesterone therapy for endometrial carcinoma PMID: 29268772
- LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage. PMID: 27404958
- LEFTY2 down-regulates MKi67 expression and FAK activity, up-regulates miR-200a and E-cadherin, and is thus a powerful negative regulator of endometrial cell proliferation and migration. PMID: 27497669
- LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1. PMID: 27606670
- Lefty A may account for the tumor suppressive activity of human adult stem cells. PMID: 22469982
- Findings suggest that Lefty2 is negatively modulated by miR-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification. PMID: 21266536
- Findings show that during embryonic development, EBAF/LEFTY B plays important roles in decidualization and embryo implantation. PMID: 21401636
- findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression PMID: 9230066
- may provide a crucial signal for endometrial breakdown and bleeding by triggering expression of several matrix metalloproteinases PMID: 12215426
- nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells PMID: 15308665
- Addition of recombinant LEFTY-A to explants induced MMP-9 in most samples, a response prevented by ovarian steroids. PMID: 15536155
- LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation. PMID: 17038673
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相關(guān)疾病：Left-right axis malformations (LRAM)
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亞細(xì)胞定位：Secreted.
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蛋白家族：TGF-beta family
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組織特異性：Mesenchymal cells of the endometrial stroma.
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數(shù)據(jù)庫(kù)鏈接：
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