TLE4 Antibody

中文名稱：

TLE4兔多克隆抗體
貨號：

CSB-PA523988LA01HU
規(guī)格：

￥440
圖片：
Immunofluorescence staining of Hela cells with CSB-PA523988LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情
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靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) TLE4 Polyclonal antibody
Uniprot No.：

Q04727
基因名：

TLE4
別名：

TLE4 antibody; GRG4 antibody; KIAA1261 antibody; Transducin-like enhancer protein 4 antibody; Grg-4 antibody; Groucho-related protein 4 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Transducin-like enhancer protein 4 protein (284-394AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，TLE4 Antibody (CSB-PA523988LA01HU)，的標(biāo)記方式是Non-conjugated。對于TLE4 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA523988LB01HU	TLE4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA523988LC01HU	TLE4 Antibody, FITC conjugated
Biotin	CSB-PA523988LD01HU	TLE4 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression.
基因功能參考文獻：
1. the loss of TLE4 confers proliferative advantage to leukemic cells, simultaneous with an upregulation of a pro- inflammatory signature mediated through aberrant increases in Wnt signaling activity PMID: 27486062
2. the results suggested that TLE4, a potential prognostic biomarker for colorectal cancer, plays an important role in the development and progression of human colorectal cancer. PMID: 26701208
3. PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing. PMID: 25631048
4. Groucho related gene Grg4 robustly activates the expression of a BMP reporter gene, as well as enhancing and sustaining the upregulation of the endogenous Id1 gene induced by BMP7. PMID: 24099773
5. Displacing coactivators CREB-binding protein/p300 while promoting the recruitment of a corepressor, Grg4. PMID: 22927467
6. Grg4 recruits the arginine methyltransferase PRMT5 to chromatin resulting in symmetric H4R3 dimethylation. PMID: 22169276
7. germ cell-specific RBMY and hnRNP G-T proteins were more efficient in stimulating TLE4-T incorporation than somatically expressed hnRNP G protein. PMID: 19893608
8. Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors PMID: 17060451
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亞細胞定位：

Nucleus.
蛋白家族：

WD repeat Groucho/TLE family
組織特異性：

In all tissues examined, mostly in brain, and muscle.
數(shù)據(jù)庫鏈接：

HGNC: 11840

OMIM: 605132

KEGG: hsa:7091

STRING: 9606.ENSP00000365735

UniGene: Hs.444213

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