TLE4 Antibody
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中文名稱：TLE4兔多克隆抗體
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貨號：CSB-PA004300
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規格：￥1090
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圖片：
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Western Blot analysis of RAT-MUSCLE cells using TLE4 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：TLE4
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別名：TLE4 antibody; GRG4 antibody; KIAA1261 antibody; Transducin-like enhancer protein 4 antibody; Grg-4 antibody; Groucho-related protein 4 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human TLE4.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression.
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基因功能參考文獻：
- the loss of TLE4 confers proliferative advantage to leukemic cells, simultaneous with an upregulation of a pro- inflammatory signature mediated through aberrant increases in Wnt signaling activity PMID: 27486062
- the results suggested that TLE4, a potential prognostic biomarker for colorectal cancer, plays an important role in the development and progression of human colorectal cancer. PMID: 26701208
- PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing. PMID: 25631048
- Groucho related gene Grg4 robustly activates the expression of a BMP reporter gene, as well as enhancing and sustaining the upregulation of the endogenous Id1 gene induced by BMP7. PMID: 24099773
- Displacing coactivators CREB-binding protein/p300 while promoting the recruitment of a corepressor, Grg4. PMID: 22927467
- Grg4 recruits the arginine methyltransferase PRMT5 to chromatin resulting in symmetric H4R3 dimethylation. PMID: 22169276
- germ cell-specific RBMY and hnRNP G-T proteins were more efficient in stimulating TLE4-T incorporation than somatically expressed hnRNP G protein. PMID: 19893608
- Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors PMID: 17060451
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亞細胞定位：Nucleus.
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蛋白家族：WD repeat Groucho/TLE family
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組織特異性：In all tissues examined, mostly in brain, and muscle.
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數據庫鏈接：
