TLE4 Antibody, HRP conjugated
-
中文名稱：TLE4兔多克隆抗體, HRP偶聯
-
貨號：CSB-PA523988LB01HU
-
規格：￥880
-
其他：
產品詳情
-
產品名稱：Rabbit anti-Homo sapiens (Human) TLE4 Polyclonal antibody
-
Uniprot No.：
-
基因名：TLE4
-
別名：TLE4 antibody; GRG4 antibody; KIAA1261 antibody; Transducin-like enhancer protein 4 antibody; Grg-4 antibody; Groucho-related protein 4 antibody
-
宿主：Rabbit
-
反應種屬：Human
-
免疫原：Recombinant Human Transducin-like enhancer protein 4 protein (284-394AA)
-
免疫原種屬：Homo sapiens (Human)
-
標記方式：HRP
-
克隆類型：Polyclonal
-
抗體亞型：IgG
-
純化方式：>95%, Protein G purified
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
-
應用范圍：ELISA
-
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
-
功能：Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression.
-
基因功能參考文獻：
- the loss of TLE4 confers proliferative advantage to leukemic cells, simultaneous with an upregulation of a pro- inflammatory signature mediated through aberrant increases in Wnt signaling activity PMID: 27486062
- the results suggested that TLE4, a potential prognostic biomarker for colorectal cancer, plays an important role in the development and progression of human colorectal cancer. PMID: 26701208
- PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing. PMID: 25631048
- Groucho related gene Grg4 robustly activates the expression of a BMP reporter gene, as well as enhancing and sustaining the upregulation of the endogenous Id1 gene induced by BMP7. PMID: 24099773
- Displacing coactivators CREB-binding protein/p300 while promoting the recruitment of a corepressor, Grg4. PMID: 22927467
- Grg4 recruits the arginine methyltransferase PRMT5 to chromatin resulting in symmetric H4R3 dimethylation. PMID: 22169276
- germ cell-specific RBMY and hnRNP G-T proteins were more efficient in stimulating TLE4-T incorporation than somatically expressed hnRNP G protein. PMID: 19893608
- Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors PMID: 17060451
顯示更多
收起更多
-
亞細胞定位：Nucleus.
-
蛋白家族：WD repeat Groucho/TLE family
-
組織特異性：In all tissues examined, mostly in brain, and muscle.
-
數據庫鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
