RAB5C Antibody

中文名稱(chēng)：

RAB5C兔多克隆抗體
貨號(hào)：

CSB-PA041280
規(guī)格：

￥1100
圖片：
Gel: 10%SDS-PAGE,Lysate: 40 μg,Lane 1-2: A549 cells, Lovo cells,Primary antibody: CSB-PA041280(RAB5C Antibody) at dilution 1/100 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds
其他：

產(chǎn)品詳情

Uniprot No.：

P51148
基因名：

RAB5C
別名：

L1880 antibody; RAB; member of RAS oncogene family like antibody; RAB5C antibody; RAB5C; member of RAS oncogene family antibody; RAB5C; member RAS oncogene family antibody; RAB5C_HUMAN antibody; RAB5CL antibody; RAB5L antibody; RABL antibody; Ras-related protein Rab-5C antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthetic peptide of Human RAB5C
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Protein transport. Probably involved in vesicular traffic.
基因功能參考文獻(xiàn)：
1. We identify RAB5C as a new candidate gene for type-2 diabetes risk with a functional role in endosomal type-2 diabetes module. Functional analysis shows that RAB5C is tyrosine phosphorylated. Data analysis reveals a tyrosine phosphorylation motif in the GTP binding site of RAB5C which may be targeted by insulin receptor. Insulin-dependent tyrosine phosphorylation of RAB5C is inhibited by overexpression of HACD3 (PTPLAD1). PMID: 30300385
2. Enforced miR-509 expression in NALM6 cells reduced RAB5C mRNA and protein levels, and RAB5C was demonstrated to be a direct target of miR-509. PMID: 25368993
3. PLP2 and RAB5C are binding partners of TPD52. PMID: 24604726
4. Rab5C modulates Rac1-mediated cell motility. PMID: 24587345
5. GTP-Rab5c also bound to AMAP1, and activation of Rab5c by EGFR signaling was necessary to promote the intracellular association of AMAP1 and PRKD2 PMID: 22734003
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亞細(xì)胞定位：

Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome.
蛋白家族：

Small GTPase superfamily, Rab family
數(shù)據(jù)庫(kù)鏈接：

HGNC: 9785

OMIM: 604037

KEGG: hsa:5878

STRING: 9606.ENSP00000345689

UniGene: Hs.650382

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