PRKACG Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PRKACG Polyclonal antibody
Uniprot No.：

P22612
基因名：

PRKACG
別名：

cAMP-dependent protein kinase catalytic subunit gamma antibody; KAPCG_HUMAN antibody; KAPG antibody; PKA C gamma antibody; PKA C-gamma antibody; PKACg antibody; PRKACG antibody; Protein kinase cAMP dependent catalytic gamma antibody; Serine (threonine) protein kinase antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human cAMP-dependent protein kinase catalytic subunit gamma protein (1-43AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
基因功能參考文獻：
1. The missense p.74Ile>Met PRKACG mutation is associated with a marked defect in proplatelet formation and a low level in filamin A in megakaryocytes. PMID: 25061177
2. PKA-mediated phosphorylation of GPIbbeta at Ser(166) negatively regulates VWF binding to GPIb-IX and is one of the mechanisms by which PKA mediates platelet inhibition PMID: 12361948
3. Results suggest that Cgamma and Calpha differ in structure and function in vitro, supporting the hypothesis that functionally different C-subunit isozymes could affect cAMP signal transduction downstream of protein kinase A activation. PMID: 15039079
相關疾病：

Bleeding disorder, platelet-type 19 (BDPLT19)
蛋白家族：

Protein kinase superfamily, AGC Ser/Thr protein kinase family, cAMP subfamily
組織特異性：

Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript.
數據庫鏈接：

HGNC: 9382

OMIM: 176893

KEGG: hsa:5568

STRING: 9606.ENSP00000366488

UniGene: Hs.158029

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