PLA1A Antibody, HRP conjugated
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中文名稱：PLA1A兔多克隆抗體, HRP偶聯
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貨號：CSB-PA018084LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PLA1A Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：AA986889 antibody; NMD antibody; OTTHUMP00000215248 antibody; OTTHUMP00000215249 antibody; OTTHUMP00000215250 antibody; Phosphatidylserine specific phospholipase A1 antibody; Phosphatidylserine specific phospholipase A1alpha antibody; Phosphatidylserine-specific phospholipase A1 antibody; Phospholipase A1 member A antibody; pla1a antibody; PLA1A_HUMAN antibody; PS PLA1 antibody; PS-PLA1 antibody; PSPLA 1 antibody; PSPLA1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Phospholipase A1 member A protein (293-398AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling. Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production. Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein.; Hydrolyzes lyso-PS but not PS.
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基因功能參考文獻：
- Serum PS-PLA1 levels were significantly higher in the melanoma subjects and associated with the clinical stages. PMID: 29500864
- the LysoPA levels might be determined largely by LysoPC and LysoPI (possible precursors) and the PS-PLA1-mediated pathway might be involved in the production of LysoPS in gastric cancer. PMID: 28143894
- PS-PLA1 expression in colorectal cancer is associated with tumor invasion and metastasis. PMID: 25750298
- These data suggest that PLA1A plays an important role in bridging the membrane-associated NS2-E2 complex and the NS5A-associated replication complex via its interaction with hepatitis C virus E2, NS2, and NS5A. PMID: 25505071
- PLA1A2 polymorphism is associated with mortality in participants whose hemoglobin A1c ranges from 5.5% to 6.5%. PMID: 24886443
- Overall, our study shed the light on new structural features of the phospholipase activity of pancreatic lipase family members. PMID: 24368210
- These results suggest that the expression of PS-PLA(1) mRNA in THP-1-derived macrophages is activated via TLR4. PMID: 20573295
- polymorphisms in the gene encoding phosphatidylserine-specific phospholipase A1 PMID: 12436198
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亞細胞定位：Secreted.
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蛋白家族：AB hydrolase superfamily, Lipase family
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組織特異性：Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.
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數據庫鏈接：
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