PKD1L1 Antibody

中文名稱：

PKD1L1兔多克隆抗體
貨號：

CSB-PA823467LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA823467LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA823467LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PKD1L1 Polyclonal antibody
Uniprot No.：

Q8TDX9
基因名：

PKD1L1
別名：

PKD1L1 antibody; UNQ5785/PRO19563 antibody; Polycystic kidney disease protein 1-like 1 antibody; PC1-like 1 protein antibody; Polycystin-1L1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Polycystic kidney disease protein 1-like 1 protein (921-1164AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PKD1L1 Antibody (CSB-PA823467LA01HU)，的標記方式是Non-conjugated。對于PKD1L1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA823467LB01HU	PKD1L1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA823467LC01HU	PKD1L1 Antibody, FITC conjugated
Biotin	CSB-PA823467LD01HU	PKD1L1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning.
基因功能參考文獻：
1. The authors report that the human PKD2-L1 selectivity filter is partially selective to calcium ions (Ca(2+)) moving into the cell, but blocked by high internal Ca(2+)concentrations, a unique feature of this transient receptor potential (TRP) channel family member. PMID: 27348301
2. identification of bi-allelic PKD1L1 mutations recapitulates previous findings regarding phenotypic consequences of loss of function of the orthologous genes in mice and medaka fish and further expands our understanding of genetic contributions to laterality defects in humans PMID: 27616478
相關疾病：

Heterotaxy, visceral, 8, autosomal (HTX8)
亞細胞定位：

Cell projection, cilium membrane; Multi-pass membrane protein.
蛋白家族：

Polycystin family
組織特異性：

Detected in testis and in fetal and adult heart.
數據庫鏈接：

HGNC: 18053

OMIM: 609721

KEGG: hsa:168507

STRING: 9606.ENSP00000289672

UniGene: Hs.195979

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