PCOLCE Antibody

中文名稱：

PCOLCE兔多克隆抗體
貨號：

CSB-PA614881LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA614881LA01HU diluted at 1:100 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PCOLCE Polyclonal antibody
Uniprot No.：

Q15113
基因名：

PCOLCE
別名：

PCOC1_HUMAN antibody; Pcolce antibody; PCOLE 1 antibody; PCOLE1 antibody; PCPE antibody; PCPE-1 antibody; PCPE1 antibody; Procollagen C endopeptidase enhancer antibody; Procollagen C-endopeptidase enhancer 1 antibody; Procollagen C-endopeptidase enhancer antibody; Procollagen C-proteinase enhancer 1 antibody; Procollagen COOH-terminal proteinase enhancer 1 antibody; procollagen, type 1, COOH-terminal proteinase enhancer antibody; Type 1 procollagen C-proteinase enhancer protein antibody; Type I procollagen COOH-terminal proteinase enhancer antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Procollagen C-endopeptidase enhancer 1 protein (169-449AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PCOLCE Antibody (CSB-PA614881LA01HU)，的標記方式是Non-conjugated。對于PCOLCE Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA614881LB01HU	PCOLCE Antibody, HRP conjugated	ELISA
FITC	CSB-PA614881LC01HU	PCOLCE Antibody, FITC conjugated
Biotin	CSB-PA614881LD01HU	PCOLCE Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.; C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
基因功能參考文獻：
1. Serum PCPE-1 might be used as a noninvasive marker of liver fibrosis in chronic hepatitis B. PMID: 29683980
2. Results suggest that PCPE-1 binding to syndecans and/or fibronectin may control collagen fibril assembly on the cell surface. PMID: 25286301
3. The analysis of the PCPE-1 interaction network based on Gene Ontology terms suggests that, besides its role in collagen deposition, PCPE-1 might be involved in tumour growth, neurodegenerative diseases and angiogenesis. PMID: 24117177
4. The results of this study suggested that nuclear entrapment of PCOLCE and its extracellular depletion represents a novel molecular mechanism in late-onset muscle fibrosis. PMID: 23815790
5. Procollagen C-proteinase enhancer grasps the stalk of the C-propeptide trimer to boost collagen precursor maturation. PMID: 23550162
6. data generated by our system, support our hypothesis that combined data on PCPE concentration and isoforms may be useful for the diagnosis and follow-up of bone diseases PMID: 21569766
7. Procollagen C-proteinase enhancer stimulates procollagen processing by binding to the C-propeptide region only. PMID: 21940633
8. procollagen C-proteinase enhancer-1 (PCPE-1) binds to heparin/heparan sulfate and has a role in interaction with cells PMID: 20729553
9. Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity. PMID: 20207734
10. Data show that only those containing both PCPE1 CUB1 and CUB2 were capable of enhancing BMP-1 activity and binding to a mini-procollagen substrate with nanomolar affinity. PMID: 19801683
11. PCPE binds to sites on either side of the procollagen cleavage site, thereby facilitating the action of procollagen C-proteinases. PMID: 12105202
12. PCPE1 and PCPE2 were found to be collagen-binding proteins, capable of binding at multiple sites on the triple helical portions of fibrillar collagens and also capable of competing for such binding with procollagen C-proteinases PMID: 12393877
13. procollagen C-proteinase enhancer is an elongated multidomain glycoprotein as shown by small angle x-ray scattering PMID: 12486138
14. the three-dimensional structure of the NTR domain of human PCOLCE1 is the first example of a structural domain with the canonical features of an NTR module PMID: 12670942
15. chordinase activity of BMP1 is not enhanced by PCPE-1 PMID: 15817489
16. tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains PMID: 16507574
17. PCPE-stimulating activity requires a calcium binding motif in the CUB1 domain that is highly conserved among CUB-containing proteins PMID: 17446170
18. in bone fracture patients, 12 proteins were related to bone/cartilage metabolism, including: TGF-beta induced protein IG-H(3), cartilage acidic protein 1, procollagen C proteinase enhancer protein and TGF-beta receptor III. PMID: 17602227
19. PCPE-1 interacts with beta2-microglobulin (beta2-m) and may help initiate beta2-m amyloid fibril formation in connective tissues PMID: 18164932
20. Procollagen I mRNA expression was decreased by synovial fluid from patients with prosthesis loosening. PMID: 18350290
21. the sPCPE1 glycopattern appears to be associated with the physiological and pathological states of bone PMID: 19361460
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亞細胞定位：

Secreted.
數據庫鏈接：

HGNC: 8738

OMIM: 600270

KEGG: hsa:5118

STRING: 9606.ENSP00000223061

UniGene: Hs.202097

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