Recombinant Human Procollagen C-endopeptidase enhancer 1 (PCOLCE)

中文名稱：

人PCOLCE重組蛋白
貨號：

CSB-YP614881HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人PCOLCE重組蛋白
貨號：

CSB-EP614881HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人PCOLCE重組蛋白
貨號：

CSB-EP614881HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PCOLCE重組蛋白
貨號：

CSB-BP614881HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人PCOLCE重組蛋白
貨號：

CSB-MP614881HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PCOLCE
Uniprot No.：

Q15113
別名：

PCOC1_HUMAN; Pcolce; PCOLE 1; PCOLE1; PCPE; PCPE-1; PCPE1; Procollagen C endopeptidase enhancer ; Procollagen C-endopeptidase enhancer 1; Procollagen C-endopeptidase enhancer; Procollagen C-proteinase enhancer 1; Procollagen COOH-terminal proteinase enhancer 1; procollagen, type 1, COOH-terminal proteinase enhancer; Type 1 procollagen C-proteinase enhancer protein; Type I procollagen COOH-terminal proteinase enhancer
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

26-449
氨基酸序列

QTPNY TRPVFLCGGD VKGESGYVAS EGFPNLYPPN KECIWTITVP EGQTVSLSFR VFDLELHPAC RYDALEVFAG SGTSGQRLGR FCGTFRPAPL VAPGNQVTLR MTTDEGTGGR GFLLWYSGRA TSGTEHQFCG GRLEKAQGTL TTPNWPESDY PPGISCSWHI IAPPDQVIAL TFEKFDLEPD TYCRYDSVSV FNGAVSDDSR RLGKFCGDAV PGSISSEGNE LLVQFVSDLS VTADGFSASY KTLPRGTAKE GQGPGPKRGT EPKVKLPPKS QPPEKTEESP SAPDAPTCPK QCRRTGTLQS NFCASSLVVT ATVKSMVREP GEGLAVTVSL IGAYKTGGLD LPSPPTGASL KFYVPCKQCP PMKKGVSYLL MGQVEENRGP VLPPESFVVL HRPNQDQILT NLSKRKCPSQ PVRAAASQD
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.; C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
基因功能參考文獻：
1. Serum PCPE-1 might be used as a noninvasive marker of liver fibrosis in chronic hepatitis B. PMID: 29683980
2. Results suggest that PCPE-1 binding to syndecans and/or fibronectin may control collagen fibril assembly on the cell surface. PMID: 25286301
3. The analysis of the PCPE-1 interaction network based on Gene Ontology terms suggests that, besides its role in collagen deposition, PCPE-1 might be involved in tumour growth, neurodegenerative diseases and angiogenesis. PMID: 24117177
4. The results of this study suggested that nuclear entrapment of PCOLCE and its extracellular depletion represents a novel molecular mechanism in late-onset muscle fibrosis. PMID: 23815790
5. Procollagen C-proteinase enhancer grasps the stalk of the C-propeptide trimer to boost collagen precursor maturation. PMID: 23550162
6. data generated by our system, support our hypothesis that combined data on PCPE concentration and isoforms may be useful for the diagnosis and follow-up of bone diseases PMID: 21569766
7. Procollagen C-proteinase enhancer stimulates procollagen processing by binding to the C-propeptide region only. PMID: 21940633
8. procollagen C-proteinase enhancer-1 (PCPE-1) binds to heparin/heparan sulfate and has a role in interaction with cells PMID: 20729553
9. Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity. PMID: 20207734
10. Data show that only those containing both PCPE1 CUB1 and CUB2 were capable of enhancing BMP-1 activity and binding to a mini-procollagen substrate with nanomolar affinity. PMID: 19801683
11. PCPE binds to sites on either side of the procollagen cleavage site, thereby facilitating the action of procollagen C-proteinases. PMID: 12105202
12. PCPE1 and PCPE2 were found to be collagen-binding proteins, capable of binding at multiple sites on the triple helical portions of fibrillar collagens and also capable of competing for such binding with procollagen C-proteinases PMID: 12393877
13. procollagen C-proteinase enhancer is an elongated multidomain glycoprotein as shown by small angle x-ray scattering PMID: 12486138
14. the three-dimensional structure of the NTR domain of human PCOLCE1 is the first example of a structural domain with the canonical features of an NTR module PMID: 12670942
15. chordinase activity of BMP1 is not enhanced by PCPE-1 PMID: 15817489
16. tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains PMID: 16507574
17. PCPE-stimulating activity requires a calcium binding motif in the CUB1 domain that is highly conserved among CUB-containing proteins PMID: 17446170
18. in bone fracture patients, 12 proteins were related to bone/cartilage metabolism, including: TGF-beta induced protein IG-H(3), cartilage acidic protein 1, procollagen C proteinase enhancer protein and TGF-beta receptor III. PMID: 17602227
19. PCPE-1 interacts with beta2-microglobulin (beta2-m) and may help initiate beta2-m amyloid fibril formation in connective tissues PMID: 18164932
20. Procollagen I mRNA expression was decreased by synovial fluid from patients with prosthesis loosening. PMID: 18350290
21. the sPCPE1 glycopattern appears to be associated with the physiological and pathological states of bone PMID: 19361460
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亞細胞定位：

Secreted.
數據庫鏈接：

HGNC: 8738

OMIM: 600270

KEGG: hsa:5118

STRING: 9606.ENSP00000223061

UniGene: Hs.202097