LHPP Antibody, Biotin conjugated

說明書

中文名稱：

LHPP兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA867114HD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) LHPP Polyclonal antibody
Uniprot No.：

Q9H008
基因名：

LHPP
別名：

FLJ44846 antibody; FLJ46044 antibody; HDHD2B antibody; hLHPP antibody; lhpp antibody; LHPP_HUMAN antibody; Phospholysine phosphohistidine inorganic pyrophosphate phosphatase antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Phospholysine phosphohistidine inorganic pyrophosphate phosphatase protein (1-270AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency.
基因功能參考文獻：
1. LHPP suppresses cell proliferation and metastasis in cervical cancer, and promotes apoptosis by suppressing AKT activation. PMID: 29944886
2. in patients with hepatocellular carcinoma, low expression of LHPP correlated with increased tumour severity and reduced overall survival; thus LHPP is a protein histidine phosphatase and tumour suppressor, suggesting that deregulated histidine phosphorylation is oncogenic PMID: 29562234
3. LHPP is associated with the interplay of risky sexual behaviors and alcohol dependence. PMID: 27531626
4. Patients with major depressive disorder with LHPP rs35936514 CT/TT genotype have increased activity in certain brain regions. PMID: 27843651
5. LHPP gene variation is associated with oral cavity and pharyngeal cancer. PMID: 27749845
6. Lhpp or a product of a collinear brain-specific transcript, therefore, may interact with Htr1a in the pathogenesis of major depression PMID: 18268499
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

HAD-like hydrolase superfamily
組織特異性：

Expressed in brain, and at lower levels in liver and kidney. Detected in thyroid (at protein level). Expressed in liver, kidney and moderately in brain.
數據庫鏈接：

HGNC: 30042

OMIM: 617231

KEGG: hsa:64077

STRING: 9606.ENSP00000357835

UniGene: Hs.527748

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