Acetyl-HIST1H1A (K21) Antibody
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中文名稱：Acetyl-HIST1H1A (K21)兔多克隆抗體
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貨號：CSB-PA010376OA21acHU
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規格：￥440
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圖片：
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Immunocytochemistry analysis of CSB-PA010376OA21acHU diluted at 1:25 and staining in Hela cells(treated with 30mM sodium butyrate for 4h) performed on a Leica BondTM system. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) HIST1H1A Polyclonal antibody
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Uniprot No.：
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基因名：HIST1H1A
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別名：Histone H1.1 (Histone H1a), HIST1H1A, H1F1
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from Human Histone H1.1 protein (18-30aa)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, ICC
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推薦稀釋比：
Application Recommended Dilution ICC 1:10-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
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基因功能參考文獻：
- Data indicate that IgGs possessing an affinity to histone H1 were isolated by affinity chromatography and size exclusion chromatography. PMID: 28361854
- Proper binding of histone H1.1 to chromatin is determined by the simultaneous and synergistic binding of its folded wing helix domain -C-terminal domains to the nucleosome. PMID: 26182371
- HIST1 cluster PcG methylation has a role in epigenesis in acute myeloid leukemia PMID: 25482132
- Results suggest the potential for histone H1 phosphorylation at threonine 146 as a clinical biomarker in breast cancer. PMID: 24601643
- fluorescence recovery after photobleaching analyses suggested that TAF-I beta enhances the dissociation of H1.1 from chromatin in the living cell PMID: 21940793
- Data show that the multifunctional histone chaperone NPM1 interacts with linker histone H1 through its first acidic stretch (residues 120-132). PMID: 21425800
- the C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo PMID: 14985337
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亞細胞定位：Nucleus. Chromosome. Note=Mainly localizes in euchromatin.
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蛋白家族：Histone H1/H5 family
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數據庫鏈接：
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