Mono-methyl-HIST1H1A (K21) Antibody

說明書

中文名稱：

Mono-methyl-HIST1H1A (K21)兔多克隆抗體
貨號：

CSB-PA010376OA21me1HU
規格：

￥440
圖片：
Immunocytochemistry analysis of CSB-PA010376OA21me1HU diluted at 1:20 and staining in Hela cells performed on a Leica BondTM system. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) HIST1H1A Polyclonal antibody
Uniprot No.：

Q02539
基因名：

HIST1H1A
別名：

Histone H1.1 (Histone H1a), HIST1H1A, H1F1
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthesized peptide derived from Human Histone H1.1 protein (18-30aa)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, ICC

推薦稀釋比：

Application	Recommended Dilution
ICC	1:10-1:100

Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.
基因功能參考文獻：
1. Data indicate that IgGs possessing an affinity to histone H1 were isolated by affinity chromatography and size exclusion chromatography. PMID: 28361854
2. Proper binding of histone H1.1 to chromatin is determined by the simultaneous and synergistic binding of its folded wing helix domain -C-terminal domains to the nucleosome. PMID: 26182371
3. HIST1 cluster PcG methylation has a role in epigenesis in acute myeloid leukemia PMID: 25482132
4. Results suggest the potential for histone H1 phosphorylation at threonine 146 as a clinical biomarker in breast cancer. PMID: 24601643
5. fluorescence recovery after photobleaching analyses suggested that TAF-I beta enhances the dissociation of H1.1 from chromatin in the living cell PMID: 21940793
6. Data show that the multifunctional histone chaperone NPM1 interacts with linker histone H1 through its first acidic stretch (residues 120-132). PMID: 21425800
7. the C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo PMID: 14985337
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亞細胞定位：

Nucleus. Chromosome. Note=Mainly localizes in euchromatin.
蛋白家族：

Histone H1/H5 family
數據庫鏈接：

HGNC: 4715

OMIM: 142709

KEGG: hsa:3024

STRING: 9606.ENSP00000244573

UniGene: Hs.150206

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