SMAD4
Mothers against decapentaplegic homolog 4 is a protein in humans that is encoded by SMAD4 gene. In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling.
SMAD4 Antibodies
SMAD4 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA021789GA01HU | SMAD4 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA825890 | SMAD4 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA619768GA01HU | SMAD4 Antibody | Human | ELISA,WB,IHC |
| CSB-PA009961 | SMAD4 Antibody | Human,Mouse,Rat,Monkey | WB, IHC, IF, ELISA |
| CSB-PA619768LA01HU | SMAD4 Antibody | Human | ELISA, WB, IHC, IP |
| CSB-PA619768LB01HU | SMAD4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA619768LC01HU | SMAD4 Antibody, FITC conjugated | Human | |
| CSB-PA619768LD01HU | SMAD4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA551397A0HU | SMAD4 Recombinant Monoclonal Antibody | Human | ELISA, WB |
SMAD4 Proteins
SMAD4 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021789MO CSB-EP021789MO CSB-BP021789MO CSB-MP021789MO CSB-EP021789MO-B |
Recombinant Mouse Mothers against decapentaplegic homolog 4 (Smad4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SMAD4 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021789RA CSB-EP021789RA CSB-BP021789RA CSB-MP021789RA CSB-EP021789RA-B |
Recombinant Rat Mothers against decapentaplegic homolog 4 (Smad4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SMAD4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP619768HU CSB-EP619768HU CSB-BP619768HU CSB-MP619768HU CSB-EP619768HU-B |
Recombinant Human Mothers against decapentaplegic homolog 4 (SMAD4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SMAD4 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP627061BO CSB-EP627061BO CSB-BP627061BO CSB-MP627061BO CSB-EP627061BO-B |
Recombinant Bovine Mothers against decapentaplegic homolog 4 (SMAD4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SMAD4 Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP884388PI CSB-EP884388PI CSB-BP884388PI CSB-MP884388PI CSB-EP884388PI-B |
Recombinant Pig Mothers against decapentaplegic homolog 4 (SMAD4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SMAD4 ELISA Kit
SMAD4 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12749h | Human Mothers against decapentaplegic homolog 4,Smad4 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 6.25 pg/mL |
