KRT18

KRT18，全稱為keratin 18，是一種常見的I型中間絲蛋白，與角蛋白8共同構(gòu)成中間絲骨架，主要表達(dá)于單層上皮組織中。KRT18蛋白也被稱為K18、CK-18等，其在細(xì)胞骨架中起到維持細(xì)胞形態(tài)和結(jié)構(gòu)穩(wěn)定的作用。KRT18蛋白的表達(dá)水平與細(xì)胞增殖和分化密切相關(guān)，其異常表達(dá)與多種疾病相關(guān)，如肝纖維化、肝癌、結(jié)腸癌等。研究表明，KRT18蛋白可作為腫瘤診斷和預(yù)后的生物標(biāo)志物。在藥物研發(fā)方面，針對(duì)KRT18蛋白的靶向藥物正在開發(fā)中，以期通過調(diào)節(jié)其表達(dá)水平來治療相關(guān)疾病。

熱銷產(chǎn)品

Recombinant Human Keratin, type I cytoskeletal 18 (KRT18) (CSB-EP012519HUe1)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

KRT18 Antibody (CSB-PA10629A0Rb)

驗(yàn)證數(shù)據(jù)

Western blot
All lanes: KRT18 antibody at 2µg/ml
Lane 1: K562 whole cell lysate
Lane 2: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 49 kDa
Observed band size: 49 kDa

Western blot
All lanes: KRT18 antibody at 12µg/ml
Lane 1: A431 whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: Jurkat whole cell lysate
Lane 4: Zebrafish lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 49 kDa
Observed band size: 49 kDa

Western Blot
Positive WB detected in: K562 whole cell lysate, Hela whole cell lysate
All lanes: KRT18 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 49 kDa
Observed band size: 49 kDa

IHC image of CSB-PA10629A0Rb diluted at 1:800 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescent analysis of HepG2 cells using CSB-PA10629A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunocytochemistry analysis of human placenta tissue using CSB-PA10629A0Rb at dilution of 1:100

Human cytokeratin 18,CK-18 ELISA Kit (CSB-E09172h)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-E09172h

規(guī)格：96T/48T

靈敏度：0.25 ng/mL

檢測(cè)范圍：0.625 ng/mL-15 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

KRT18 Antibody

KRT18 Protein

KRT18 ELISA Kit

KRT18 Antibodies

KRT18 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA10629B0Rb	KRT18 Antibody, HRP conjugated	Human	ELISA
CSB-PA10629D0Rb	KRT18 Antibody, Biotin conjugated	Human	ELISA, IHC
CSB-PA012519GA01HU	KRT18 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA10629A0Rb	KRT18 Antibody	Human, Zebrafish	ELISA, WB, IHC, IF
CSB-PA044751	Phospho-KRT18 (Ser33) Antibody	Human	ELISA,WB,IHC
CSB-PA132653	KRT18 (Ab-33) Antibody	Human	ELISA,WB,IHC
CSB-PA005823	KRT18 Antibody	Human	ELISA,WB,IHC,IF
CSB-PA000392	KRT18 Antibody	Human	WB
CSB-PA000727	Phospho-KRT18 (S33) Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA002029	KRT18 Antibody	Human,Mouse,Rat	WB, IHC, IP, IF, ELISA
CSB-PA002031	KRT18 Antibody	Human	WB, IHC, IF, ELISA
CSB-PA002044	KRT18 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA009670	Phospho-KRT18 (S52) Antibody	Human	WB, IHC, IF, ELISA
CSB-PA594188	KRT18 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA243997	KRT18 Antibody	Human,Mouse,Rat	ELISA,WB,IHC

KRT18 for H, M, R

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-MA000253	KRT18 Monoclonal Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-MA000256	KRT18 Monoclonal Antibody	Human,Mouse,Rat	ELISA,WB

KRT18 for H, M

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-MA000255	KRT18 Monoclonal Antibody	Human,Mouse	ELISA,WB

KRT18 for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA012519LA01MO	Krt18 Antibody	Mouse, Human	ELISA, WB, IHC
CSB-PA012519LB01MO	Krt18 Antibody, HRP conjugated	Mouse	ELISA
CSB-PA012519LC01MO	Krt18 Antibody, FITC conjugated	Mouse
CSB-PA012519LD01MO	Krt18 Antibody, Biotin conjugated	Mouse	ELISA

KRT18 Proteins

KRT18 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP012519MO CSB-EP012519MO CSB-BP012519MO CSB-EP012519MO-B	Recombinant Mouse Keratin, type I cytoskeletal 18 (Krt18)	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli

KRT18 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP012519HU CSB-EP012519HU-B	Recombinant Human Keratin, type I cytoskeletal 18 (KRT18)	Yeast In Vivo Biotinylation in E.coli
CSB-EP012519HU2	Recombinant Human KeRatin, type I cytoskeletal 18 (KRT18), partial	E.coli
CSB-EP012519HU1	Recombinant Human KeRatin, type I cytoskeletal 18 (KRT18), partial	E.coli
CSB-EP012519HU	Recombinant Human Keratin, type I cytoskeletal 18 (KRT18)	E.coli
CSB-MP012519HU	Recombinant Human Keratin, type I cytoskeletal 18 (KRT18)	Mammalian cell
CSB-EP012519HUe1	Recombinant Human Keratin, type I cytoskeletal 18 (KRT18)	E.coli
CSB-BP012519HU	Recombinant Human Keratin, type I cytoskeletal 18 (KRT18)	Baculovirus
CSB-EP012519HUc7	Recombinant Human Keratin, type I cytoskeletal 18 (KRT18)	E.coli
CSB-MP012519HUd9	Recombinant Human Keratin, type I cytoskeletal 18（KRT18), partial	Mammalian cell

KRT18 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP525221OEI CSB-EP525221OEI CSB-BP525221OEI CSB-MP525221OEI CSB-EP525221OEI-B	Recombinant Oncorhynchus mykiss Keratin, type I cytoskeletal 18 (krt18)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KRT18 Proteins for Scyliorhinus stellaris (Nursehound) (Greater spotted dogfish)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP528812SYB CSB-EP528812SYB CSB-BP528812SYB CSB-MP528812SYB CSB-EP528812SYB-B	Recombinant Scyliorhinus stellaris Keratin, type I cytoskeletal 18 (krt18)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KRT18 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP685592RA CSB-EP685592RA CSB-BP685592RA CSB-EP685592RA-B	Recombinant Rat Keratin, type I cytoskeletal 18 (Krt18)	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli

KRT18 Proteins for Protopterus aethiopicus (Marbled lungfish)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP705521PSV CSB-EP705521PSV CSB-BP705521PSV CSB-MP705521PSV CSB-EP705521PSV-B	Recombinant Protopterus aethiopicus Keratin, type I cytoskeletal 18 (krt18)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KRT18 Proteins for Acipenser baerii (Siberian sturgeon)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP745822AAAJ CSB-EP745822AAAJ CSB-BP745822AAAJ CSB-MP745822AAAJ CSB-EP745822AAAJ-B	Recombinant Acipenser baerii Keratin, type I cytoskeletal 18 (krt18)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KRT18 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP764749XBF CSB-EP764749XBF CSB-BP764749XBF CSB-MP764749XBF CSB-EP764749XBF-B	Recombinant Xenopus tropicalis Keratin, type I cytoskeletal 18 (krt18)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KRT18 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP772048DIL CSB-EP772048DIL CSB-BP772048DIL CSB-MP772048DIL CSB-EP772048DIL-B	Recombinant Danio rerio Keratin, type I cytoskeletal 18 (krt18)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli