INHBA
INHBA，全名為Inhibin beta A chain，常見(jiàn)別名為FSH-releasing protein。該蛋白屬于TGF-β超家族成員，參與激活素和抑制素蛋白復(fù)合物的形成，通過(guò)調(diào)節(jié)垂體分泌促卵泡激素來(lái)影響生殖系統(tǒng)的功能。此外，INHBA蛋白還在眼睛、牙齒和睪丸的發(fā)育中發(fā)揮作用。研究表明，該基因表達(dá)升高可能與人類(lèi)患者的癌癥惡病質(zhì)有關(guān)。在藥物研發(fā)方面，針對(duì)INHBA蛋白的藥物正在開(kāi)發(fā)中，例如Alnylam和Arrowhead公司分別研發(fā)了INHBE和ALK7的siRNA藥物，用于治療肥胖癥等代謝性疾病。這些藥物通過(guò)抑制INHBA蛋白的表達(dá)，有望為肥胖治療領(lǐng)域帶來(lái)突破性的進(jìn)展。
熱銷(xiāo)產(chǎn)品
Recombinant Human Inhibin beta A chain (INHBA) (Active) (CSB-MP011719HU1b0)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its ability to inhibit proliferation of MPC-11 cells. The ED50 for this effect is 0.9519-1.213 ng/mL.
Activity
Measured by its binding ability in a functional ELISA.Immobilized Human INHBA at 2 μg/ml can bind Human ACVR2A (CSB-MP001260HU1d9).The EC50 is 74.75-84.73 ng/mL.
Activity
Measured by its binding ability in a functional ELISA.Immobilized Human INHBA at 2 μg/ml can bind Human ACVR2B (CSB-MP623829HUi9).The EC50 is 45.93-52.42 ng/mL.
Activity
Measured by its binding ability in a functional ELISA.Immobilized Human INHBA at 2 μg/ml can bind Anti-INHBA recombinant antibody (CSB-RA011719MA1HU). The EC50 is 10.28-12.68 ng/mL.
Recombinant Human Inhibin beta A chain (INHBA) (CSB-BP011719HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
INHBA Antibody (CSB-PA07589A0Rb)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Hela whole cell lysate(30μg), HepG2 whole cell lysate(30μg), MCF-7 whole cell lysate(30μg)
All lanes: INHBA antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 48 kDa
Observed band size: 48 kDa
Exposure time: 120s
INHBA Antibodies
INHBA for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA011719GA01HU | INHBA Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA07589A0Rb | INHBA Antibody | Human | ELISA, WB |
| CSB-PA07589B0Rb | INHBA Antibody, HRP conjugated | Human | ELISA |
| CSB-PA07589C0Rb | INHBA Antibody, FITC conjugated | Human | |
| CSB-PA07589D0Rb | INHBA Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA005668 | INHBA Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA903855 | INHBA Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA055706 | INHBA Antibody | Human,Mouse,Rat | ELISA,WB |
INHBA Proteins
INHBA Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011719RA CSB-EP011719RA CSB-BP011719RA CSB-MP011719RA CSB-EP011719RA-B |
Recombinant Rat Inhibin beta A chain (Inhba) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INHBA Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011719SH CSB-EP011719SH CSB-BP011719SH CSB-MP011719SH CSB-EP011719SH-B |
Recombinant Sheep Inhibin beta A chain (INHBA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INHBA Proteins for Gallus gallus (Chicken)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011719CH CSB-EP011719CH CSB-BP011719CH CSB-MP011719CH CSB-EP011719CH-B |
Recombinant Chicken Inhibin beta A chain (INHBA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INHBA Proteins for Equus caballus (Horse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011719HO CSB-EP011719HO CSB-BP011719HO CSB-MP011719HO CSB-EP011719HO-B |
Recombinant Horse Inhibin beta A chain (INHBA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INHBA Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011719PI CSB-EP011719PI CSB-BP011719PI CSB-MP011719PI CSB-EP011719PI-B |
Recombinant Pig Inhibin beta A chain (INHBA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INHBA Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011719BO CSB-EP011719BO CSB-BP011719BO CSB-MP011719BO CSB-EP011719BO-B |
Recombinant Bovine Inhibin beta A chain (INHBA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INHBA Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP011719HU CSB-MP011719HU CSB-EP011719HU-B |
Recombinant Human Inhibin beta A chain (INHBA) | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP011719HU | Recombinant Human Inhibin beta A chain (INHBA) | E.coli |
| CSB-AP004011HU | Recombinant Human Inhibin beta A chain (INHBA) (Active) | Mammalian cell |
| CSB-BP011719HU | Recombinant Human Inhibin beta A chain (INHBA) | Baculovirus |
| CSB-MP011719HU-WD | Recombinant Human Inhibin beta A chain (INHBA) (Active) | Mammalian cell |
| CSB-EP011719HUc7 | Recombinant Human Inhibin beta A chain (INHBA) | E.coli |
| CSB-MP011719HU1 | Recombinant Human Inhibin beta A chain (INHBA) | Mammalian cell |
| CSB-MP011719HU1b0 | Recombinant Human Inhibin beta A chain (INHBA) (Active) | Mammalian cell |
INHBA Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP751056CA CSB-EP751056CA CSB-BP751056CA CSB-MP751056CA CSB-EP751056CA-B |
Recombinant Cat Inhibin beta A chain (INHBA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INHBA ELISA Kit
INHBA ELISA Kit for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 樣本類(lèi)型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011719BO | Bovine Inhibin beta A chain(INHBA) ELISA kit | serum, plasma, tissue homogenates | 15 pg/mL |
