INHBA Antibody
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中文名稱：INHBA兔多克隆抗體
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貨號：CSB-PA07589A0Rb
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規格：￥440
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圖片：
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Western Blot
Positive WB detected in: Hela whole cell lysate(30μg), HepG2 whole cell lysate(30μg), MCF-7 whole cell lysate(30μg)
All lanes: INHBA antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 48 kDa
Observed band size: 48 kDa
Exposure time: 120s
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) INHBA Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Activin beta-A chain antibody; EDF antibody; Erythroid differentiation factor antibody; Erythroid differentiation protein antibody; Follicle stimulating hormone releasing protein antibody; FRP antibody; FSH releasing protein antibody; INHBA antibody; INHBA_HUMAN antibody; Inhibin beta A chain antibody; Inhibin beta A subunit antibody; Inhibin, beta 1 antibody; Inhibin, beta A (activin A, activin AB alpha polypeptide) antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Inhibin beta A chain protein (311-426AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，INHBA Antibody (CSB-PA07589A0Rb)，的標記方式是Non-conjugated。對于INHBA Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
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基因功能參考文獻：
- pro-activin A share features seen in the pro-TGF-beta1 and pro-BMP-9 structures. PMID: 27373274
- Data suggest that activin A (INHBA) plays roles in inflammation, tissue repair, fibrosis, neoplastic activation of myofibroblasts, and leiomyoma development/growth. [REVIEW] PMID: 29100238
- that high expression of INHBA was associated with poor response to therapy for de novo AML, and it can serve as an adverse prognostic factor for this malignancy. PMID: 28836868
- Activin-A may induce fibrosis in NASH and alcoholic cirrhosis via activation of Kupffer cells to express pro-inflammatory molecules that promote HSC-dependent fibrogenesis and could be a target for future anti-fibrotic therapies. PMID: 29287776
- Our study provided experimental and clinical evidence for the involvement of activin A and ALK4 in the pathophysiology of atrial fibrosis and atrial fibrillation PMID: 28639003
- INHBA gene expression in gastric cancer tissue is considered a useful independent predictor of outcomes in patients with stage II/III gastric cancer who receive adjuvant chemotherapy with S-1. PMID: 28652421
- Inhibin-B secretion and FSH isoform distribution may play an integral part of follicular selection in the natural menstrual cycle. (Review) PMID: 27756855
- The present study was undertaken to evaluate the distribution of the FSHB -211 G/T in men with normal or abnormal sperm parameters from Southern Italy to assess its functional relevance on the serum levels of reproductive hormones and on sperm parameters in men. PMID: 28281143
- binding of SMAD2/3, the intracellular effectors of activin signaling, was significantly enriched at the Pmepa1 gene, which encodes a negative feedback regulator of TGF-beta signaling in cancer cells, and at the Kdm6b gene, which encodes an epigenetic regulator promoting transcriptional plasticity. PMID: 26215835
- analysis of a novel SMAD-independent pathway linking enhanced activin B signaling to reduced E-cadherin expression and increased migration in type II endometrial cancer PMID: 27223076
- High INHBA expression is associated with lung adenocarcinoma. PMID: 26950277
- activin A signaling has a role in melanoma growth and metastasis through immune evasion PMID: 28844941
- These data provide evidence that eosinophils release activin A and that this function is enhanced when eosinophils are present in an allergen-induced inflammatory environment. PMID: 27001469
- These results demonstrate that activin induces skin carcinogenesis via attraction and reprogramming of macrophages and identify novel activin targets involved in tumor formation. PMID: 27932444
- our results defined a novel pathway in which dysregulation of the RUNX2/INHBA axis due to miR-376c downregulation fosters lymph node metastasis in head and neck squamous cell carcinoma PMID: 27760788
- The activin-A to follistatin ratio may play a role in determining the clinical phenotype of preterm birth as preterm labor or preterm premature rupture of membranes. PMID: 27159193
- A screen of a human protein library identified activin A as a potent regulator of follicular helper T cells cell differentiation. PMID: 27376469
- Activin A is higher in patients with steatohepatitis than both lean and obese controls PMID: 27621190
- INHBA expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
- Activin A and preeclamptic serum upregulate ET-1, ICAM-1, and VCAM-1 in human umbilical vein endothelial cells, consistent with activin A contributing to the pathophysiology of preeclampsia. PMID: 27155341
- Data show that dedifferentiated chondrocytes can be redifferentiated following treatment with the chimeric erythroid differentiation factor (activin A)/bone morphogenetic protein 2 (BMP2) ligand AB235. PMID: 26563344
- Study shows that INHBA and FST are induced by seminal fluid in cervical tissues and thus, may contribute to regulation of the post-coital response in women. PMID: 26415587
- Inhibin betaA is translationally regulated by TGFbeta via hnRNP E1. PMID: 26096938
- we show a role for autocrine Activin signaling in the regulation of colony formation, cell migration and invasion in Barrett's tumorigenesis. PMID: 26447543
- Our study uncovers the PITX2-induced expression of TGFB1/2/3 as well as INHBA genes (p < 0.01) followed by SMAD2/3-dependent TGF-b signalling pathway in ovarian cancer cells PMID: 26298390
- changes in Follistatin levels during pregnancy contribute to the control of the activin A system PMID: 25565002
- Overexpression of activin A in OSCCs, which is controlled by downregulation of miR-143/miR-145 cluster, regulates apoptosis, proliferation and invasiveness, and it is clinically correlated with lymph node metastasis and poor survival. PMID: 26317418
- Activin A inhibited signaling by BMP-6 and BMP-9 by competing for type 2 receptors ACVR2A and ACVR2B. PMID: 26047946
- Data suggest that activin A [plus bone morphogenic protein 4 (BMP4)] strongly stimulates germ cell differentiation potential of human embryonic stem cells; this stimulation appear to depend on gene expression regulation by activin A. PMID: 25634576
- Increased serum level of activin A indicates its role in the pathogenesis of asthma, particularly in underweight and overweight patients. PMID: 25729977
- Data suggest that an SNP in promoter region of ACVR2A (activin A receptor type IIA; rs1424954, the pre-eclampsia susceptibility allele) down-regulates signal transduction in trophoblasts in response to excess activin-A (as seen in pre-eclampsia). PMID: 25659497
- able to restore glucose-stimulated insulin secretion in islets from type 2 diabetic donors PMID: 25833251
- our study suggests that increased circulating concentrations of ActA may contribute to the development of cachexia in cancer patients. PMID: 25751105
- Low activin-A expression was correlated with the occurrence, development, metastasis and malignant degree of lung adenocarcinoma. PMID: 25796148
- Data suggest that activin A (dimer of INHBA), especially in lateral hypothalamus, plays role in neuronal sensing of free amino acids, appetite regulation, and neuronal plasticity. [REVIEW] PMID: 25200295
- Activin-A and -B are abundantly expressed in mesothelioma tumor tissue. PMID: 25557874
- INHBA overexpression implies adverse clinical outcomes for urothelial carcinoma, justifying it is a potential prognostic biomarker and a novel therapeutic target in UC PMID: 25488476
- overexpression of INHBA in mesenchymal cells increases colony formation potential of epithelial cells, suggesting that it contributes to the dynamic reciprocity between breast mesenchymal and epithelial cells. PMID: 24916766
- Activin A promoted chemotaxis, migration and proliferation of human periodontal ligament cells, and caused an increase in fibroblastic differentiation of these cells while down-regulating their osteoblastic differentiation. PMID: 24928494
- High activin A signal promotes cancer progression and is involved in cachexia in a subset of pancreatic cancer. PMID: 25449777
- Activin A is an anti-lymphangiogenic factor, but because of its pleiotropic effects on cell mobility it appears not suitable as a pharmacological target. PMID: 25084052
- Activin A, B, and AB have similar effects on steroidogenesis in human granulosa cells; in contrast, activin AC is not biologically active and does not act as a competitive antagonist. PMID: 25062451
- expression of erythroid differentiation regulator 1 was negatively correlated with the malignant potential in various skin tumors. PMID: 24168163
- Endothelial cells initiate a smooth muscle cell differentiation program in adjacent adipose stromal cells via induction activin A expression. PMID: 25114097
- We identified an unreported germline mutation of the INHA gene encoding the alpha-subunit, the partner of the betaA-subunit. This mutation also alters the secreted activin/inhibin ratio, by disrupting both inhibin A and inhibin B biosynthesis. PMID: 24302632
- Circulating activin A levels are associated with impaired myocardial glucose metabolism and high left ventricular mass/volume ratio in men with uncomplicated type 2 diabetes, reflecting a potential detrimental role in early human diabetic cardiomyopathy. PMID: 24134550
- Follistatin, by its ability to neutralize the actions of activin A may be of value as an antifibrotic for radiation induced fibrosis. PMID: 24204752
- the Activin/ALK4 pathway directly recruits PTP1B and stimulates its release from the endoplasmic reticulum through ALK4-mediated cleavage. PMID: 24139759
- Activin A released from EAT-T2D inhibits insulin action via the induction of miR-143 in cardiomyocytes PMID: 23812417
- Overexpression of the INHBA gene is considered a useful independent predictor of outcomes in patients with gastric cancer after curative surgery. PMID: 24778035
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亞細胞定位：Secreted.
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蛋白家族：TGF-beta family
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數據庫鏈接：
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