ILDR2
ILDR2蛋白全稱為免疫球蛋白樣結(jié)構(gòu)域受體2，也被稱為IMD2或LISCH樣蛋白，其分子結(jié)構(gòu)中含有典型的免疫球蛋白功能域，主要分布于上皮細(xì)胞表面。該蛋白在維持細(xì)胞極性及細(xì)胞間連接中發(fā)揮關(guān)鍵作用，尤其與內(nèi)耳毛細(xì)胞、肝臟及乳腺等組織的發(fā)育密切相關(guān)。ILDR2功能異?？赡芤l(fā)先天性耳聾、膽管閉鎖及部分乳腺癌的發(fā)生，例如某些病例中ILDR2基因突變導(dǎo)致聽覺神經(jīng)信號(hào)傳遞受阻，進(jìn)而引發(fā)非綜合征型聽力損傷。
近年來，ILDR2與代謝調(diào)控的關(guān)聯(lián)逐漸被揭示。在糖尿病研究中，ILDR2通過影響胰島素分泌細(xì)胞的完整性，可能參與血糖平衡調(diào)節(jié)。此外，針對(duì)ILDR2的藥物開發(fā)尚處于早期階段，但其在腫瘤微環(huán)境中的特殊表達(dá)模式已引起關(guān)注，部分抗體藥物偶聯(lián)物（ADC）研究將其作為潛在靶點(diǎn)。ILDR2與緊密連接蛋白家族的功能協(xié)同性，為治療上皮屏障相關(guān)疾病提供了新思路，例如炎癥性腸病的干預(yù)策略探索。
熱銷產(chǎn)品
Recombinant Human Immunoglobulin-like domain-containing receptor 2 (ILDR2), partial (CSB-EP751251HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ILDR2 Recombinant Monoclonal Antibody (CSB-RA751251MA1HU)
驗(yàn)證數(shù)據(jù)
Immunofluorescence?staining?of?Hela?cell?with?CSB-RA751251MA1HU?at?1:30,?counter-stained?with?DAPI.?The?cells?were?fixed?in?4%?formaldehyde?and?blocked?in?10%?normal?Goat?Serum.?The?cells?were?then?incubated?with?the?antibody?overnight?at?4C.?The?secondary?antibody?was?FITC-conjugated?AffiniPure?Goat?Anti-Human?IgG(H+L).
Immunofluorescence?staining?of U251?cell?with?CSB-RA751251MA1HU?at?1:30,?counter-stained?with?DAPI.?The?cells?were?fixed?in?4%?formaldehyde?and?blocked?in?10%?normal?Goat?Serum.?The?cells?were?then?incubated?with?the?antibody?overnight?at?4C.?The?secondary?antibody?was?FITC-conjugated?AffiniPure?Goat?Anti-Human?IgG(H+L).
Overlay Peak curve showing Jurkat cells stained with CSB-RA751251MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100.Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
ILDR2 Antibodies
ILDR2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-RA751251MA1HU | ILDR2 Recombinant Monoclonal Antibody | Human | ELISA, IF, FC |
ILDR2 Proteins
ILDR2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP751251HU | Recombinant Human Immunoglobulin-like domain-containing receptor 2 (ILDR2), partial | Yeast |
| CSB-EP751251HU | Recombinant Human Immunoglobulin-like domain-containing receptor 2 (ILDR2), partial | E.coli |
| CSB-BP751251HU CSB-MP751251HU CSB-EP751251HU-B |
Recombinant Human Immunoglobulin-like domain-containing receptor 2 (ILDR2), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
