IGF2BP2
IGF2BP2，全稱為Insulin-like growth factor 2 mRNA-binding protein 2，別名IMP2或VICKZ2，是一種RNA結(jié)合蛋白，主要功能是結(jié)合胰島素樣生長(zhǎng)因子2（IGF2）的mRNA，調(diào)節(jié)其翻譯效率。該蛋白在多種組織中表達(dá)，與細(xì)胞代謝密切相關(guān)，參與調(diào)節(jié)細(xì)胞生長(zhǎng)、分化和代謝等過(guò)程。IGF2BP2在多種癌癥中高表達(dá)，如頭頸部鱗癌、口腔鱗狀細(xì)胞癌、喉癌、鼻咽癌和下咽癌等，與腫瘤的分期、淋巴結(jié)轉(zhuǎn)移及不良預(yù)后相關(guān)。研究表明，IGF2BP2通過(guò)結(jié)合靶mRNA（如IGF2、MYC和β-catenin等）促進(jìn)其穩(wěn)定性和翻譯效率，從而影響細(xì)胞生長(zhǎng)、分化和代謝。此外，IGF2BP2還與miRNAs、lncRNAs和circRNAs等非編碼RNA相互作用，共同參與對(duì)靶mRNA的調(diào)控。目前，針對(duì)IGF2BP2的藥物研發(fā)尚處于早期階段，但已發(fā)現(xiàn)一些能夠干擾IGF2BP2與關(guān)鍵靶mRNA結(jié)合的小分子化合物，為癌癥治療提供了新的思路。
熱銷產(chǎn)品
IGF2BP2 Antibody (CSB-PA908724)
驗(yàn)證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA908724(IGF2BP2 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA908724(IGF2BP2 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: CSB-PA908724(IGF2BP2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
Human Insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2) ELISA kit (CSB-EL011091HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL011091HU
規(guī)格：96T/48T
靈敏度：31.25 pg/mL
檢測(cè)范圍：125 pg/mL-8000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
IGF2BP2 Antibodies
IGF2BP2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA011091GA01HU | IGF2BP2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA006676 | IGF2BP2 Antibody | Human | WB, ELISA |
| CSB-PA908724 | IGF2BP2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA215752 | IGF2BP2 Antibody | Human,Mouse | ELISA,WB |
IGF2BP2 Proteins
IGF2BP2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP897316HU CSB-EP897316HU CSB-BP897316HU CSB-MP897316HU CSB-EP897316HU-B |
Recombinant Human Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IGF2BP2 ELISA Kit
IGF2BP2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011091HU | Human Insulin-like growth factor 2 mRNA-binding protein 2(IGF2BP2) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 31.25 pg/mL |
